Outcomes and Safety of Surgical Lung Biopsy for Interstitial Lung Disease

Correlation Between Surgical Lung Biopsy and Autopsy Findings and Clinical Data in Patients With Diffuse Pulmonary Infiltrates and Acute Respiratory Failure

“…3,4,[14][15][16] With the exception of a mortality percentage of 21.4% reported by Ferson et al, 17 more recent series refer indices lower than 8% directly related to the biopsy procedure. [18][19][20][21] While this assertion is difficult to prove, the complications in our series did not appear to directly cause death. However, the mortality rate in the patients suffering complications, while marginally significant, suggests that such complications requires more complex patient care.…”

Evaluation of patients with fibrotic interstitial lung disease: A Canadian Thoracic Society position statement

“…56 Approximately 20% of patients have discordant pathology patterns (eg., UIP in one lobe and NSIP in another lobe), 55,57 indicating the importance of sampling at least 2 lobes. 3,55,58 In two previous studies, the clinical behavior and prognosis of patients with discordant NSIP and UIP findings were similar to patients with UIP on both biopsies, emphasizing the need to identify a UIP pattern when present. 55,57 SLBx for histopathologic sampling in the evaluation of fibrotic ILD should be pursued following a detailed discussion with the patient regarding potential benefits and risks.…”

“…59 Nonfatal post-operative complications are reported in 8.4%-56% of patients undergoing SLBx, including acute exacerbation of ILD; pneumonia; pleural effusion; chronic chest pain; prolonged air leak; post-operative need for mechanical ventilation; and readmission to hospital within 1 month of discharge. 40,58,[60][61][62] Common risk factors and relative contraindications to SLBx are listed in Table 1. 52,59,62 Transbronchial lung cryobiopsy When should transbronchial lung cryobiopsy be performed in the evaluation of fibrotic ILD?…”

Idiopathic pulmonary fibrosis: The current state of the problem

“…-Диффузионная способность легких по окиси углерода (DL co ) ≤35% -предиктор высокого риска смерти [3,32,33].…”