Outcomes following surgical versus endovascular treatment of spinal dural arteriovenous fistula: a systematic review and meta-analysis

Abstract

Although surgical resection is associated with a complete cure in most cases of spinal dural arteriovenous fistulas (SDAVF), there has been an increasing trend towards embolisation. We performed a systematic review and meta-analysis comparing surgical resection with endovascular treatment in terms of success of treatment, rate of recurrence and complications. A literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Strength of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation Working Group system. Surgical outcomes such as initial treatment failure, late recurrence, neurological improvement and complications were compared between the two approaches. We included 57 studies with 2029 patients, of which 32 studies with 1341 patients directly compared surgery (n=590) and embolisation (n=751). Surgery was found to be associated with significantly lower odds of initial treatment failure (OR: 0.15, 95% CI 0.09 to 0.24, I2 0%, p<0.001) and late recurrence (OR 0.18, 95% CI 0.09 to 0.39, I2 0%, p<0.001). The odds of neurological improvement following surgery were also significantly higher compared with embolisation alone (OR: 2.73, CI:1.67 to 4.48, I2 :49.5%, p<0.001). No difference in complication rates was observed between the two approaches (OR 1.78, 95% CI 0.97 to 3.26, I2 0%, p=0.063). Onyx was associated with significantly higher odds of initial failure/late recurrence as compared with n-butyl 2-cyanoacrylate (OR: 3.87, CI: 1.73 to 8.68, I2 :0%, p<0.001). Surgery may be associated with superior outcomes for SDAVFs in comparison to endovascular occlusion. Newer embolisation agents like Onyx have not conferred a significant improvement in occlusion rate.

Functional Outcome in Patients with Dural Arteriovenous Fistulae after Surgical Treatment

“…The higher success rate reported in the meta-analysis conducted by Goyal et al compared with previous studies and meta-analyses might be due to advances in endovascular techniques [18]. It might, however, also just demonstrate a more realistic success rate due to a larger number of patients [18]. Still, the reported failure rate of 19.8% with endovascular occlusion was significantly higher, compared to 2.8% with surgical occlusion; the late recurrence rate of 11.2%, was much higher with endovascular occlusion compared to 1.6% with surgical occlusion [18].…”

“…This might be due to different reasons. The higher success rate reported in the meta-analysis conducted by Goyal et al compared with previous studies and meta-analyses might be due to advances in endovascular techniques [18]. It might, however, also just demonstrate a more realistic success rate due to a larger number of patients [18].…”

“…A recent meta-analysis compared outcome between surgically and endovascular treated patients [18]. They found an improved outcome for SDAVF in surgically compared to endovascular treated patients [18].…”

“…A recent meta-analysis compared outcome between surgically and endovascular treated patients [18]. They found an improved outcome for SDAVF in surgically compared to endovascular treated patients [18]. Improvement of symptoms following complete occlusion has been reported in about two-third of patients with sensory symptoms improving less frequently [19].…”

“…Only if this can be achieved endovascular occlusion appears to be efficient [22]. A recent meta-analysis showed increasing occlusion rates with endovascular treatment compared to older publications [18,20,23]. This might be due to different reasons.…”