Outcomes in patients with gram-negative sepsis treated with gentamicin

Pillans, Peter I.; Iedema, Joel; Donovan, Peter; Newbery, R.S.; Whitehead, Venetia; Halliday, Cameron; Sheehy, Robert; Springford, Annaka; Patterson, Tina

doi:10.1177/2042098612439495

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Gentamicin is an aminoglycoside that is effective against a wide range of pathogens as well. Several studies including the present study confirms their considerable anti—bacterial activities [ 20 , 21 , 22 ].…”

Section: Discussionsupporting

confidence: 86%

Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya

et al. 2017

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Tungiasis or jigger infestation is a parasitic disease caused by the female sand flea Tunga penetrans. Secondary infection of the lesions caused by this flea is common in endemic communities. This study sought to shed light on the bacterial pathogens causing secondary infections in tungiasis lesions and their susceptibility profiles to commonly prescribed antibiotics. Participants were recruited with the help of Community Health Workers. Swabs were taken from lesions which showed signs of secondary infection. Identification of suspected bacteria colonies was done by colony morphology, Gram staining, and biochemical tests. The Kirby Bauer disc diffusion test was used to determine the drug susceptibility profiles. Out of 37 participants, from whom swabs were collected, specimen were positive in 29 and 8 had no growth. From these, 10 different strains of bacteria were isolated. Two were Gram positive bacteria and they were, Staphylococcus epidermidis (38.3%) and Staphylococcus aureus (21.3%). Eight were Gram negative namely Enterobacter cloacae (8.5%), Proteus species (8.5%), Klebsiellla species (6.4%), Aeromonas sobria (4.3%), Citrobacter species (4.3%), Proteus mirabillis(4.3%), Enterobacter amnigenus (2.1%) and Klebsiella pneumoniae (2.1%). The methicillin resistant S. aureus (MRSA) isolated were also resistant to clindamycin, kanamycin, erythromycin, nalidixic acid, trimethorprim sulfamethoxazole and tetracycline. All the Gram negative and Gram positive bacteria isolates were sensitive to gentamicin and norfloxacin drugs. Results from this study confirms the presence of resistant bacteria in tungiasis lesions hence highlighting the significance of secondary infection of the lesions in endemic communties. This therefore suggests that antimicrobial susceptibility testing may be considered to guide in identification of appropriate antibiotics and treatment therapy among tungiasis patients.

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Section: Discussionsupporting

confidence: 86%

Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya

et al. 2017

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“…Inappropriate antibiotic prescription can increase the duration of hospitalization and mortality 1-4. Inappropriate use and dosing of antibiotics can lead to antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of aminoglycosides utilization in intensive care units of a teaching hospital in southern Iran

Vazin¹,

Mirjalili²,

Asadi³

2019

Pharm Pract (Granada)

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Background:Inappropriate use of antimicrobial agents is one of the most important factors in inducing resistance and prolonged hospitalization as well as increase in patient mortality rate.Objective:The aim of this study was to evaluate aminoglycosides (AGs) usage pattern at intensive care units (ICUs) of Nemazee hospital Shiraz, Iran.Methods:In this cross-sectional study, the usage pattern of AGs was evaluated during 32 months. Guidelines for AGs usage were approved by the drug and therapeutic committee of the hospital, and criteria were developed to assess 11 parameters involving AGs therapy, such as proper indication for the use of the drug, dosage and duration of therapy. Clinical parameters, such as microbial culture and sensitivity, serum creatinine (SCr) and creatinine clearance, and white blood cell count were evaluated.Results:Ninety-five patients were recruited, 50 male and 45 females. In most patients (64%) the origin of infection was hospital and only in 36% of them, community was the source. Ventilator associated pneumonia (27%), central nervous system (25%) and urinary tract infection (10%) were the most important indications for AGs prescription. Scores of AGs usage at Nemazee hospital was calculated as 5.9 out of 11, which meant that in only 54% of cases AGs prescription was based on guideline proposed by the Department of Clinical Pharmacy of Nemazee Hospital.Conclusions:Non-adherence to the guidelines occurred frequently in the ICUs of Nemazee hospital. Prescription of loading dose, and AGs level measurement were not done and evaluating microbiological data was often neglected. Incorporating pharmacists in the health care team and holding training programs for physicians and nurses with the goal of raising awareness about the proposed guideline.

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Evaluation of possible protective role of glabridin against gentamicin-instigated nephrotoxicity via attenuation of oxidative stress

Ijaz

Mustafa

Hamza

et al. 2023

Journal of King Saud University - Science

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Outcomes in patients with gram-negative sepsis treated with gentamicin

Abstract: Despite the modest doses of gentamicin used in an elderly population with comorbidities, as well as the absence of optimal TDM, outcomes were favourable without preventable serious toxicity.

Cited by 4 publications

References 20 publications

Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya

Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya

Evaluation of aminoglycosides utilization in intensive care units of a teaching hospital in southern Iran

Evaluation of possible protective role of glabridin against gentamicin-instigated nephrotoxicity via attenuation of oxidative stress

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