Outcomes of different subgroups of smear-positive retreatment patients under RNTCP in rural West Bengal, India

Mukherjee, Abhijit; Sarkar, Anirban; Saha, Indranil; Biswas, Bijay; Bhattacharyya, Parthasarathi

doi:10.22605/rrh926

Cited by 12 publications

(17 citation statements)

References 3 publications

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“…6 Among retreatment patients the sputum conversion rate at the end of the IP was similar to the observations of Mukherjee and colleagues who reported 72.8%. 7 Favourable treatment outcomes with respect to better cure rates and lesser failure and default rates was seen significantly more in Category I patients compared to Category II patients which was similar to the observations made by Pardeshi and colleagues. 11 This meant that treatment outcome rates in Category II is poor compared to Category I.…”

Section: Discussionsupporting

confidence: 86%

“…Relapse as the commonest cause of retreatment was supported by studies by Mehta and colleagues 10 and Mukherjee and colleagues 7 but these other studies found failure as the next most common cause which was different from our study. In another study done in Maharashtra, defaulters constituted the major group among patients put on Category II treatment.…”

Section: Discussionsupporting

confidence: 60%

“…4 Another study done in West Bengal reported the mean age of Category II patients to be 41.8 years which was more than our findings. 7 More than three-quarters of patients in our study were males. A similar observation of male preponderance among tuberculosis cases has been made in other studies too.…”

Section: Discussionmentioning

confidence: 68%

See 2 more Smart Citations

Treatment outcomes among new smear positive and retreatment cases of tuberculosis in Mangalore, South India – a descriptive study.

Joseph

Nagaraj²,

Bhat³

et al. 2011

AMJ

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 60%

See 1 more Smart Citation

Treatment outcomes among new smear positive and retreatment cases of tuberculosis in Mangalore, South India – a descriptive study.

Joseph

Nagaraj²,

Bhat³

et al. 2011

AMJ

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“…We observed unfavourable outcome commonly among high grade sputum positive patients that is also collaborative with the Mukherjee et al study observations. They also found unfavourable outcome most likely among treatment failure subgroup but we observed it more among treatment after default category patients (46.3%) [ 13 ].…”

Section: Discussionsupporting

confidence: 48%

Predictors of Treatment Outcome for Retreatment Pulmonary Tuberculosis Cases among Tribal People of an Eastern India District: A Prospective Cohort Study

Saha

2016

Tuberculosis Research and Treatment

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Objective. The study was conducted to assess the treatment outcome of different category retreatment cases with the aim of finding out the important predictors of unfavorable outcomes. Methodology. This hospital based prospective cohort study was conducted in three tuberculosis units (TUs) of west Midnapore (a district of Eastern India), covering mostly the tribal populated areas. Patients who were registered for Category II antituberculosis treatment between 1st quarter of 2013 (Jan to Mar) and 4th quarter of 2013 (Oct to Dec) were considered as our study cohort and they were followed up till December 2014. The study was started with 177 patients but ultimately ended with 165 patients. Results. Unfavorable outcome was observed among 24.8% patients. Among them mostly 51.2% were defaulter, 22% were failure case, and 26.8% died during treatment. Patients, who were minority by religion, were found 4 times more vulnerable for unfavorable outcome. Unfavorable outcome was found 7 times more common among retreatment TB cases who remain sputum positive after completion of initiation phase of Category II treatment. Conclusion. Programmatic approach should be specified to address the minority by religion population and to reduce the load of sputum positive cases after completion of initiation phase treatment by tracking them.

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“…The programme concluded that previously treated patients should undergo drug susceptibility testing and patients with documented resistance (including mono resistance) would receive a regimen based on drug susceptibility results [7]. A retrospective study done in West Bengal among smear positive re-treatment patients reported that unfavorable outcome was more among the treatment failure subgroup and those with high grades of sputum positivity [8]. A systematic review on DOTS for TB relapses in India reported that majority of the relapses presented within six months of treatment completion.…”

Section: Re-treatment Cases and Their Significancementioning

confidence: 99%

Treatment Outcomes among Patients Treated With Category II Antituberculosis Regimen: Short Review

G¹

2018

Mycobact Dis

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Tuberculosis (TB) is one of the leading causes of morbidity and mortality, especially in developing and underdeveloped nations. To add to the burden, drug resistant TB is on the rise and India is handling the dual burden of drug sensitive TB and resistant TB. Previously treated TB cases when compared to the newly diagnosed, have poor treatment success rates and nearly seven times higher incidence of multi drug resistant TB. Proper management of patients treated with Category-II anti-tuberculous treatment (ATT) can result in decrease in emergence of drug resistant bacilli and interruption of disease transmission. Very few studies have reported the treatment outcomes of re-treatment cases and the associated factors in the literature. Favourable outcome rates are highly variable among the failure, relapse and default subgroups. There are many challenges faced by the treating physicians in diagnosis, treatment and follow-up of the re-treatment cases. This review describes the outcomes of patients treated with Category-II ATT and the challenges in managing the previously treated cases successfully. Relapse type of retreatment cases had better success rates compared to other subgroups.

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Outcomes of different subgroups of smear-positive retreatment patients under RNTCP in rural West Bengal, India

Abstract: Outcomes of different subgroups of smear-positive retreatment patients under RNTCP in rural West Bengal, India

Cited by 12 publications

References 3 publications

Treatment outcomes among new smear positive and retreatment cases of tuberculosis in Mangalore, South India – a descriptive study.

Treatment outcomes among new smear positive and retreatment cases of tuberculosis in Mangalore, South India – a descriptive study.

Predictors of Treatment Outcome for Retreatment Pulmonary Tuberculosis Cases among Tribal People of an Eastern India District: A Prospective Cohort Study

Treatment Outcomes among Patients Treated With Category II Antituberculosis Regimen: Short Review

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