Outcomes of Fat Injection Laryngoplasty in Unilateral Vocal Cord Paralysis

Abstract

Fat injection laryngoplasty seems to be effective in enhancing acoustic and quality of life outcomes in patients with unilateral vocal cord paralysis. The effect is sustainable over 12 months.

Treatment of vocal cord paralysis by autologous fat injection: Our experience with 41 patients

“…The improvement in voice quality parameters observed in this study is consistent with those in previous studies . For instance, a study on 33 patients with UVCP in Taiwan observed that jitter had improved from 2.7 at baseline to 1.3 at month 3, which is comparable with our observed effect size. Hartl and colleagues also observed that acoustic parameters (eg, jitter and shimmer) reduced quickly after one month of surgery and maintained up to 24 months .…”

“…Hartl and colleagues also observed that acoustic parameters (eg, jitter and shimmer) reduced quickly after one month of surgery and maintained up to 24 months . Moreover, the index of vocal ageing (ie, harmonics‐to‐noise ratio) in our study was improved by almost 57% at months 1‐3 which was also observed by a previous study . We also found substantial improvement in glottal patency, glottal gap, vocal cord and voice handicap index.…”

“…9 Moreover, the index of vocal ageing (ie, harmonics-to-noise ratio) in our study was improved by almost 57% at months 1-3 which was also observed by a previous study. 5 We also found substantial improvement in glottal patency, glottal gap, vocal cord and voice handicap index. Out of 41 patients, 40 patients had voice handicap index above 35 at baseline, and after 3 months of surgery, there was only one patient remained at that level.…”

Quality of the voice after injection of hyaluronic acid into the vocal fold

“…The literature indicates that hyaluronic acid injected into Reinke’s space has the ability to stimulate growth of new connective tissue – collagen, fibroblasts, and hyaluronic acid – providing long-term filling and elasticity of the vocal fold [13]. In comparison to other implantable materials such as autologous fat, Teflon, collagen, or calcium hydroxylapatite, hyaluronic acid seems to be quite resistant to resorption [2,14,15]. As reported by other authors, resorption of hyaluronic acid takes about 6–12 months.…”

Neues Verfahren zur Liposuktion und Fettaugmentation nach Chordektomie

“…Die Injektion von Eigenfett ist seit mehr als 20 Jahren in der Hals-Nasen-Ohrenheilkunde etabliert. Regelmäßig werden Stimmlippenaugmentationen [1,2] sowie Lipoinjektionen bei Narben und Konturdefiziten durchgeführt [3,4]. Das entnommene Fettgewebe enthält interessanterweise relevante Mengen an adipogenen Stammzellen [5,6], welchen wundheilungsfördernde Eigenschaften zugeschrieben werden [7].…”