Outcomes of infants with abdominal wall defects over 18years

Kong, Juin Yee; Yeo, Kee Thai; Abdel-Latif, Mohamed E; Bajuk, Barbara; Holland, A.J.A.; Adams, Susan; Jiwane, Ashish; Heck, Sandra; Yeong, Michael; Lui, Kei; Oei, Ju Lee

doi:10.1016/j.jpedsurg.2016.06.003

Cited by 28 publications

(9 citation statements)

References 40 publications

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“…The prevalence of gastroschisis in São Paulo state from 2005–2016 was 2.15 (95% CI: 2.05–2.26) cases per 10,000 LB, and it significantly increased by 27.61% from 1.74 (95% CI: 1.42–2.08) to 2.23 (95% CI: 1.85–2.61) cases per 10,000 LB, with an increasing annual percent change of 2.6% (95% CI: 0.0–5.2). The increasing prevalence in São Paulo state is concordant with other studies worldwide 3,9–11,14–18 , but not with Li et al . 2 , which found a decreasing prevalence of gastroschisis in all 14 cities of the Liaoning Province in China from 6.87 to 0.80 per 10,000 LB during 2006–2015.…”

Section: Discussionsupporting

confidence: 86%

“…Our findings are consistent with those of other studies that showed that neonates born with gastroschisis are often Caucasian, born preterm, and with low birthweight 8,14,15,21,22 . Most mothers usually have low educational status, and they are more likely to give birth by cesarean delivery, as in USA 1,10,23 and Australia 18,24 . In the Kirollos et al .…”

Section: Discussionmentioning

confidence: 99%

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Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005–2016

Calderon¹,

Santos

Abreu

et al. 2019

Sci Rep

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To estimate the gastroschisis seasonality and trend of prevalence in recent years, stratified by maternal age and geographical clusters of São Paulo state, a population–based study was designed. We used data from the Live Births Information System (SINASC) in São Paulo state, Brazil, from 2005 to 2016. Trends of prevalence were evaluated for the specific subgroups using the Prais–Winsten regression model, and the Durbin–Watson test was used, to estimate the regression coefficient, the annual percent change (APC), and 95% confidence interval (CI). We observed 1576 cases of gastroschisis among 7,317,657 live births (LB), a prevalence of 2.154 (95% CI: 2.047–2.260) per 10,000 LB which included, 50.6% males, 67.4% Caucasians, 53.4% preterm births, and 80.9% caesarean births. The prevalence of gastroschisis significantly increased by 2.6% (95% CI: 0.0–5.2) per year, and this trend was higher in mothers aged 30–34 years (APC: 10.2, 95% CI: 1.4–19.4) than in mothers of other age groups. Between 2011 and 2016, we identified the existence of seasonality based on the date of conception in the middle months of the year (p = 0.002). This is the first and largest population–based study summarizing current epidemiology and identifying trend of prevalence of gastroschisis in São Paulo state.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005–2016

Calderon¹,

Santos

Abreu

et al. 2019

Sci Rep

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“…Gastroschisis is associated with substantial perinatal mortality (ranging from 4% to 17%) . Neonates with gastroschisis require surgical repair of the defect and may require parenteral feeding and extended hospitalisation . It has been suggested that mode of delivery may influence outcomes .…”

Section: Introductionmentioning

confidence: 99%

Mode of delivery and mortality among neonates with gastroschisis: A population‐based cohort in Texas

López

Benjamin

Raut

et al. 2019

Paediatric Perinatal Epid

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Background: Mode of delivery is hypothesised to influence clinical outcomes among neonates with gastroschisis. Results from previous studies of neonatal mortality have been mixed; however, most studies have been small, clinical cohorts and have not adjusted for potential confounders.Objectives: To evaluate whether caesarean delivery is associated with mortality among neonates with gastroschisis. Methods:We studied liveborn, nonsyndromic neonates with gastroschisis delivered during 1999-2014 using data from the Texas Birth Defect Registry. Using multivariable Cox proportional hazards regression, we separately assessed the relationship between caesarean and death during two different time periods, prior to 29 days (<29 days) and prior to 365 days (<365 days) after delivery, adjusting for potential confounders. We also updated a recent meta-analysis on this relationship, combining our estimates with those from the literature. Results:Among 2925 neonates with gastroschisis, 63% were delivered by caesarean.No associations were observed between caesarean delivery and death <29 days (adjusted hazard ratio [aHR] 1.00, 95% confidence interval [CI] 0.63, 1.61) or <365 days after delivery (aHR 0.99, 95% CI 0.70, 1.41). The results were similar among those with additional malformations and among those without additional malformations.When we combined our estimate with prior estimates from the literature, results were similar (combined risk ratio [RR] 1.00, 95% CI 0.84, 1.19). Conclusions:Although caesarean rates among neonates with gastroschisis were high, our results suggest that mode of delivery is not associated with mortality among these individuals. However, data on morbidity outcomes (eg intestinal damage, infection) were not available in this study. K E Y W O R D S caesarean section, gastroschisis, mode of delivery, mortality, vaginal delivery A commentary based on this paper appears in pages 213-214 | 205 LOPEZ Et aL. S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Lopez A, Benjamin RH, Raut JR, et al. Mode of delivery and mortality among neonates with gastroschisis: A population-based cohort in Texas. Paediatr

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“…Our results are close to the results from other centers worldwide, where the survival rate is reported to be 73%-87.5%. However, it is important to highlight that international medical literature in majority describes cases of isolated omphalocele, whereas in our study group both isolated cases and cases with other coexisiting defects were described 13,18,19 .…”

Section: Abnormalities Of Fetal Heart Function In Fetuses With Omphalmentioning

confidence: 64%

Congenital Heart Defects Coexisting with Omphalocele - the Important Prognostic Factor

Sokołowski

Respondek-Liberska

Krekora

et al. 2018

Prenatal Cardiology

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Introduction: The aim of this study was to evaluate the following parameters of fetuses and neonates with omphalocele: the prevalence of coexisting congenital heart defects (CHD), abnormalities in heart function and the impact of coexisting CHD on fetal and neonatal survival. Material and methods: The study group consisted of 69 fetuses with omphalocele diagnosed and monitored at the Department of Prenatal Cardiology in our Institute in the years 2007-2017. The retrospective analisis of patients' data was performed. For statistical analysis we used Chi-square test, t-Student test and U Mann-Whitney test.. Results: In the studied group omphalocele was an isolated defect in 31.9% of the cases (22/69), in 68.1% (47/69) coexisting defects were present, in 49.3% (34/69) the coexisting defect was CHD. The most common CHD coexisting with omphalocele were ventricular septal defect (VSD), double outlet right ventricle (DORV) and atrio-ventricular septal defect (AVSD). Abnormalities of heart function were present in 43.5% (30/69) of fetuses with omphalocele: 23.5% (8/34) with normal heart anatomy and in 62.9% (22/35) with CHD. Statistically significant differences between the group with normal heart anatomy and the group with CHD regarded: Cardiovascular Profile Score (CVPS) (median 10 points vs median 9 points, U Mann-Whitney test p=0.034), neonatal birth weight(mean 3253 g vs median 2700 g, U Mann-Whitney test p=0.003), Apgar score (median 8 vs median 7, U Mann-Whitney test p=0.038) and survival rate until discharge from hospital (85% vs 52.9%, Chi-square test p=0.034). The comparison of data from 2007-2017 with data obtained from similar analysis performed in our center in 1999-2006, revealed significant improvement in the early detection of omphalocele (median 14.5 weeks of gestation vs mean 25.4 weeks of gestation), gestational age of delivery (mean 38 weeks of gestation vs mean 34 weeks of gestation) and survival rate until discharge both in neonates with normal heart anatomy and coexisting CHD (85% and 52.9% vs 70% and 23% respectively) . Conclusions: 1. The presence of coexisting CHD is an important prognostic factor in fetuses and neonates with omphalocele, so early fetal echocardiography should be performed in every case of omphalocele. 2. During the last decade (2007-2017), in contrast to years 1999-2006, we observed significant improvement in early and complete prenatal diagnosis of omphalocele. 3. We observed improvement in strategy of obstetrical management resulting in delivering neonates in a more advanced gestational age both in the group with normal heart anatomy and the group with coexisting CHD.

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Outcomes of infants with abdominal wall defects over 18years

Cited by 28 publications

References 40 publications

Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005–2016

Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005–2016

Mode of delivery and mortality among neonates with gastroschisis: A population‐based cohort in Texas

Congenital Heart Defects Coexisting with Omphalocele - the Important Prognostic Factor

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