Outcomes of intravesical chondroitin-sulfate and combined hyaluronic-acid/chondroitin-sulfate therapy on female sexual function in bladder pain syndrome

Arslan, Burak; Gönültaş, Serkan; Gökmen, Ersin; Özman, Oktay; Avci, Mustafa Asım; Özdemir, Enver

doi:10.1007/s00192-019-04036-2

Cited by 20 publications

(15 citation statements)

References 24 publications

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“…Interstitial Cystitis/Bladder Pain Syndrome is a chronic inflammatory syndrome and seems to be related to the destruction of bladder mucosa, especially glycosaminoglycan coating, both Chondroitin Sulphate (CS) and non-sulphated–HA [ 59 , 60 ]. A therapeutic approach is the intravesical instillation of CS or a combination of CS and HA while evaluating: Female Sexual Function Index (FSFI), Visual Analog Pain Scale, Interstitial Cystitis Syndrome, and Interstitial Cystitis Problem Index.…”

Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

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Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

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This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects.

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Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

“…FSFI was higher for the control group (CS group). The last three parameters were improved in a higher manner when comparing CS/HA and CS groups [ 60 ]. No adverse reactions were reported during CS or CS/HA instillations [ 61 , 62 ].…”

Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

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“…43,44 Furthermore, the combination of HA/CS was found to be superior to intravesical CS alone in terms of improvements in pain scores and female sexual function. 45 A systematic review and meta-analysis that included 10 studies with a total of 390 patients revealed significant improvements in pain scores (O'Leary-Sant and VAS scores) with both intravesical HA and combined HA/CS. 46 The EAU guidelines, therefore, provide a weak recommendation that intravesical HA or CS be offered before more invasive measures.…”

Section: Glycosaminoglycan Layer Treatmentsmentioning

confidence: 99%

<p>Clinical Management of Bladder Pain Syndrome/Interstitial Cystitis: A Review on Current Recommendations and Emerging Treatment Options</p>

Colemeadow¹,

Sahai²,

Malde³

2020

RRU

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Bladder pain syndrome (BPS) is a chronic condition characterized by pelvic pain or pressure which is perceived to be originating from the bladder, accompanied by one or more urinary symptoms, including frequency, urgency and nocturia. The precise etiology of BPS is not fully understood. Chronic bacterial infection, defective glycosaminoglycan (GAG) layer of the bladder urothelium, inappropriate activation of mast cells in the suburothelial layer of the bladder, autoimmune-mediated mechanisms and autonomic nervous system dysfunction have all been implicated. Treatments targeted at each of these mechanisms have been developed with mixed outcomes. High-quality research into the treatment options is lacking and it is difficult to draw definite conclusions. The treatment approach is multimodal and should be patient specific, targeting the symptoms which they find most bothersome. Conservative treatment, including patient education, behavioural modification, dietary advice, stress relief and physical therapy is an essential initial management strategy for all patients. If no response is observed, oral treatments such as amitriptyline are likely to offer the greatest response. Cystoscopy is essential to phenotype patients, and Hunner lesion directed therapy with fulguration or resection can be performed at the same time. Intravesical instillation of DMSO or lidocaine, detrusor injections of botulinum toxin A and neuromodulation can be used if initial management fails to improve symptoms. Oral cyclosporin can be trialled in those experienced with its use; however, it is associated with significant adverse events and requires intense monitoring. Lastly, radical surgery should be reserved for those with severe, unremitting BPS, in which quality of life is severely affected and not improved by previously mentioned interventions. Future work investigating exact aetiological factors will help target the development of efficacious treatment options, and several promising oral and intravesical treatments are emerging.

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“…A 53-patient study compared HA alone with HA/CS combined and found no significant difference in symptom improvement between the two groups [36]. Another study showed that when used in combination or CS alone, both regimes had beneficial effects on sexual function [37].…”

Section: Hyaluronic Acid and Chondroitin Sulphatementioning

confidence: 99%

The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS?

et al. 2020

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Outcomes of intravesical chondroitin-sulfate and combined hyaluronic-acid/chondroitin-sulfate therapy on female sexual function in bladder pain syndrome

Cited by 20 publications

References 24 publications

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

<p>Clinical Management of Bladder Pain Syndrome/Interstitial Cystitis: A Review on Current Recommendations and Emerging Treatment Options</p>

The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS?

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