2020
DOI: 10.1093/ehjcvp/pvaa074
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Outcomes of renin–angiotensin–aldosterone system blockers in patients with COVID-19: a systematic review and meta-analysis

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Cited by 22 publications
(37 citation statements)
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“…However, the conclusion regarding the use of RAS blockade in COVID-19 is still inconsistent, even among several meta-analyses. Most meta-analyses have reported that ACE-I and ARB use was not associated with mortality [17][18][19] , but one showed a relationship between ACE-Is and ARBs and lower mortality among hypertensive patients with COVID-19 17 . Another meta-analysis reported an overall protective effect www.nature.com/scientificreports/ of RAS blockade with death and critical disease 20 .…”
Section: Discussionmentioning
confidence: 99%
“…However, the conclusion regarding the use of RAS blockade in COVID-19 is still inconsistent, even among several meta-analyses. Most meta-analyses have reported that ACE-I and ARB use was not associated with mortality [17][18][19] , but one showed a relationship between ACE-Is and ARBs and lower mortality among hypertensive patients with COVID-19 17 . Another meta-analysis reported an overall protective effect www.nature.com/scientificreports/ of RAS blockade with death and critical disease 20 .…”
Section: Discussionmentioning
confidence: 99%
“…In another meta-analysis, 10,014 patients with COVID-19 were included from 13 studies. ACE-I or ARB therapy was not associated with disease severity (OR, 0.88; 95% CI, 0.60–1.31) or all-cause mortality (OR, 0.95; 95% CI, 0.57–1.58) 38) .…”
Section: Relationship Between Ras Blockade and Covid-19mentioning
confidence: 90%
“…The involvement of RAS dysfunction with increased angiotensin II levels in lung injury of Covid-19 patients has previously been postulated. [4][5][6] In turn, higher levels of angiotensin II can increase aldosterone production by adrenal cortex cells. Thus, SARS-CoV2 infection can directly enhance serum aldosterone levels by promoting its detrimental activity systemically, in the lungs and endothelial cells.…”
Section: Can Aldosterone Increase Interleukin-6 Levels In Covid-19 Pnmentioning
confidence: 99%