Outcomes of standard 12-core transrectal ultrasound-guided prostate biopsy in biopsy naive Indian men -single center experience

Abstract

Introduction: Prostate cancer is now the second-most common cancer in many parts of India. Despite being the second-largest population in the world, data regarding outcomes of biopsy in Indian men are limited. We report the correlation of biopsy finding with prostate-specific antigen (PSA) level in Indian men undergoing biopsy for either elevated PSA and/or abnormal digital rectal examination (DRE) findings. Materials and Methods: We retrospectively analyzed data of 853 men who underwent TRUS-guided prostate biopsy in a single institution from January 2014 to October 2019. The biopsy was performed when serum PSA was more than 4.00 ng/mL and/or DRE findings were suspicious for malignancy. Results: Overall cancer detection rate was 38.8%. Patients were classified in five groups based on PSA levels, irrespective of DRE findings (0–3.99 ng/mL, 4.00–9.99 ng/mL, 10.00–19.99 ng/mL, 20.00–39.99 ng/mL, and ≥40 ng/mL). Overall prostate cancer detection rates at corresponding at PSA levels were 3/23 (13%), 62/282 (21.9%), 86/226 (38.05%), 66/126 (52.3%), and 165/196 (84.18%), respectively. 331 (38.8%) patients of the total 853 had suspicious DRE, the cancer detection rate in corresponding PSA groups, based on DRE alone was 3/23 (13.04%), 23/42 (54.76%), 39/56 (69.64%), 43/52 (82.69%), and 157/160 (98.13%), respectively. Conclusion: The overall prostate cancer detection rate at our center was 38.8%, which is much higher as compared to other Indian data. Our study also emphasizes the role of DRE in Indian men presenting with elevated PSA.

Diagnostic yield and outcome of transrectal ultrasound-guided prostate biopsy in Sri Lanka

“…Comparison of previous studies are shown in table S2 which had a PCa rate of 8.7-44.8% [5,[7][8][9][10]. In a previous study from Sri Lanka, the prevalence of PCa in 749 symptomatic males subjected to TRUSPB was 35.2%, which was lower than the current study [5].…”

Delayed right external iliac artery disruption after radical cystectomy: A case report and literature review

“…Vascular complications, such as intraoperative injury to blood vessels, which results in massive bleeding, are commonly reported complications of radical cystectomy, which is a catastrophic event and may potentially have an unfavorable effect on surgical mortality rates (4,5). Iliac artery pseudoaneurysm and arterioureteral fistula are rare complications following radical cystectomy (6,7). The present study described another rare case of delayed right external iliac artery disruption that occurred one month after laparoscopic radical cystectomy, without any obvious evidence of iliac artery pseudoaneurysm or arterioureteral fistula.…”