Outer Hair Cell Loss and Alterations in Glycogen Due to Tobramycin Sulfate

Postma, Duncan S.; Pecorak, John B.; Prazma, Jiri; S, Logue; Fischer, Newton D.

doi:10.1001/archotol.1976.00780080076009

Cited by 11 publications

(3 citation statements)

References 16 publications

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“…Postma et al [1976] evaluated glycogen levels and granule size in OHCs of albino guinea pigs and found that regions of the cochlea with the least amount of glycogen sustained the greatest OHC damage following administration of the antibiotic tobramycin sulfate. Postma et al [1976] concluded that the cochlear regions most susceptible to damage from antibiotics (a) normally have the lowest levels of glycogen, (b) show little or no increase in glycogen levels or granule size in the initial period following aminoglycoside treatment and (c) are the most likely to show depletion of glycogen in later stages of drug intoxication. Similar conclusions have been reached regarding glycogen levels and vulnerability to acoustic overstimulation and ischemia.…”

Section: Relationship Between Ohc Vulnerability and Glycogen Levelsmentioning

confidence: 99%

“…If the oxygen supply is insufficient or if metabolic pathways involved in oxidative phosphorylation are blocked, energy can be supplied by anaerobic breakdown of carbohydrates for a limited period of time [Spoendlin andBalogh, 1963: Vosteen, 1960]. Glycogen, a polysaccharide, is the most important energy reserve in the organ of Corti [Postma et al, 1976;Vinnikov, 1964;Yang and Han, 1991]. Decreases in glycogen levels in the cochlea have been observed following ischemic insult [Thalmann et al, 1972], exposure to ototoxic drugs [FalbeHansen, 1964;Postma et al, 1976] or acoustic overstimulation [Ishii et al, 1969] and correlated with cochlear damage.…”

Section: Introductionmentioning

confidence: 99%

“…Glycogen, a polysaccharide, is the most important energy reserve in the organ of Corti [Postma et al, 1976;Vinnikov, 1964;Yang and Han, 1991]. Decreases in glycogen levels in the cochlea have been observed following ischemic insult [Thalmann et al, 1972], exposure to ototoxic drugs [FalbeHansen, 1964;Postma et al, 1976] or acoustic overstimulation [Ishii et al, 1969] and correlated with cochlear damage. Although glycogen can serve as an energy source under both aerobic and anaerobic conditions [Postma et al, 1976;Vinnikov, 1964;Yang and Han, 1991], measures of cellular glycogen concentration can be useful as an indicator of anaerobic metabolic capacity [Peter et al, 1972].…”

Section: Introductionmentioning

confidence: 99%

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Age- and Strain-Related Differences in Dehydrogenase Activity and Glycogen Levels in CBA and C57 Mouse Cochleas

Ding¹,

McFadden²,

Wang³

et al. 1999

Audiol Neurotol

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In the C57 mouse strain, loss of sensory hair cells (HCs) begins during early adulthood, starting in the base of the cochlea and progressing toward the apex as aging continues. In contrast, the CBA mouse strain exhibits no significant cochlear histopathology until relatively late in life. These strain and age differences may be related to differences in cochlear energy metabolism. To examine this possibility, we used dehydrogenase and glycogen histochemistry to evaluate the metabolic capacities of HCs and stria vascularis (SV) in cochleas of C57 and CBA mice. Reaction product density was quantified and compared as a function of strain (1.5-month-old C57 mice vs. CBA mice) and age (CBA mice, 1.5, 18 and 36 months). Young C57 mice had significantly less HC dehydrogenase activity than CBA mice of any age, lower HC glycogen levels than 18-month-old CBA mice and lower SV glycogen levels than 18- or 36-month-old CBA animals. Within the CBA strain, HC dehydrogenase activity decreased significantly between 1.5 and 18 months of age, while glycogen levels in both HCs and SV increased over the same time period. Between 18 and 36 months, HC dehydrogenase activity and SV glycogen levels remained stable. The results show that there are significant age-related changes in energy metabolism in the inner ear of CBA mice that are correlated with age-related hearing loss. Genetically determined deficits in cochlear metabolic capacity in C57 mice could be linked to the early onset of hearing loss in this strain.

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Section: Relationship Between Ohc Vulnerability and Glycogen Levelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age- and Strain-Related Differences in Dehydrogenase Activity and Glycogen Levels in CBA and C57 Mouse Cochleas

Ding¹,

McFadden²,

Wang³

et al. 1999

Audiol Neurotol

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Ototoxizität von Antibiotika unter besonderer Berücksichtigung der Lokalbehandlung

Federspil¹

1982

HNO Praxis Heute

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Gentamicin-induced alterations of succinic dehydrogenase activity in the organ of Corti as revealed by non-decalcified frozen sections of the guinea pig's cochlea

Yang

Han

1991

Eur Arch Otorhinolaryngol

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The distribution of succinic dehydrogenase (SDH) activity and the changes of SDH activity after injection of gentamicin (GM) were observed in the organ of Corti using non-decalcified frozen sections of the guinea pig's cochlea. The distribution of SDH activity was found to increase from the apex to the basal turn. At each turn, SDH activity of the inner hair cells, the inner supporting cells and the nerve endings surrounding the supporting cell and on the hair cells presented a greater activity than that found in the outer hair cells, adjacent Deiter's cells and associated nerve endings. It was further observed that GM had a greater effect on SDH activity in the basal turn than the other turns. At each turn, a more sensitive area of response to GM was found on the nerve endings one each hair cell, especially on the outer hair cells of the basal turn.

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Outer Hair Cell Loss and Alterations in Glycogen Due to Tobramycin Sulfate

Cited by 11 publications

References 16 publications

Age- and Strain-Related Differences in Dehydrogenase Activity and Glycogen Levels in CBA and C57 Mouse Cochleas

Age- and Strain-Related Differences in Dehydrogenase Activity and Glycogen Levels in CBA and C57 Mouse Cochleas

Ototoxizität von Antibiotika unter besonderer Berücksichtigung der Lokalbehandlung

Gentamicin-induced alterations of succinic dehydrogenase activity in the organ of Corti as revealed by non-decalcified frozen sections of the guinea pig's cochlea

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