Outer Nuclear Layer Thinning in Pachychoroid Pigment Epitheliopathy

Ersöz, Mehmet Giray; Karaçorlu, Murat; Arf, Serra; Hocaoğlu, Mümin; Muslubaş, Işıl Sayman

doi:10.1097/iae.0000000000001655

Cited by 43 publications

(35 citation statements)

References 21 publications

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“…CSR as an RPE disease 8 and IZ as the representation of the region of the distal portion of the cone's outer segment which indicated contact cylinder with the apposed RPE cell body is expected that the regulation of the disease can be translated in more IZ presence by SML treatment. 21 ONL has been described as a biomarker of better prognosis in CSR [22][23][24][25] and 532-SML marginally increased the ONL thickness in our study, without statistically significant variation. Treatment was applied subfoveally if necessary.…”

Section: Discussionsupporting

confidence: 42%

<p>532-nm Subthreshold Micropulse Laser for the Treatment of Chronic Central Serous Retinopathy</p>

Sousa¹,

Calvão-Santos²,

João³

et al. 2020

OPTH

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Introduction: Subthreshold micropulse laser treatment with a 532 nm (532-SML) wavelength has been suggested as a treatment option for the treatment of chronic central serous retinopathy (cCSR). The objective is to present its effects and complications. Methods: We present a retrospective cohort study of cCSR patients submitted to 532-SML. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) parameterscentral macular thickness, subfoveal outer nuclear layer, external limiting membrane, ellipsoid band, interdigitation band, subretinal fluid and choroidal thicknesswere evaluated before and 12 weeks after treatment. A power of 50%, a duty cycle of 5%, exposure time of 200 ms and a spot size of 160 µm were the applied laser parameters. Results: We included 26 eyes. Overall there were no significant changes in visual acuity (median 0.20 (IQR 0) logMAR before and after treatment) or SD-OCT parameters. However, visual benefits occurred in 42.3% (n=11) of the patients and in half of the cases, subretinal fluid was completely reabsorbed. There were no complications. Conclusion: In this study, 532-SML was overall ineffective on cCSR as it did not lead to significant changes in the overall median visual acuity and SD-OCT parameters. However, some patients may have benefited functionally and anatomically from the treatment; further investigation is necessary to understand the potential of 532-SML.

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Section: Discussionsupporting

confidence: 42%

<p>532-nm Subthreshold Micropulse Laser for the Treatment of Chronic Central Serous Retinopathy</p>

Sousa¹,

Calvão-Santos²,

João³

et al. 2020

OPTH

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“…Using OCT angiography (OCTA), the spatial correlation between choriocapillaris blood flow and pachyvessels can be evaluated in a depth-resolved manner. In g-j, choroidal thickening and choriocapillaris attenuation seen in crosssectional OCT (g) can be correlated with OCTA findings showing attenuation of flow signal (dash white outline) within the choriocapillaris (h) and inner choroid (i) which directly overlie areas with dilated outer choroidal vessels (j) thinner in eyes with pachychoroid pigment epitheliopathy (PPE) than in eyes with uncomplicated pachychoroid in one study, suggesting that degeneration of photoreceptors and/ or RPE may also occur, even in the absence of SRF [20].…”

Section: Attenuation Of Inner Choroidmentioning

confidence: 66%

“…In view of the wide range of choroidal thickness and the multiple factors which may influence this parameter, there is no definitive quantitative threshold for defining an eye as having abnormally thick choroid. However, many investigators may consider subfoveal choroidal thickness >300 µm as pathological [4,20]. Regional variation of choroidal thickness has also been described, with studies showing the thickest region beneath the fovea and thinnest areas nasally [21].…”

Section: Choroidal Features Common To Pachychoroid Disease Entitiesmentioning

confidence: 99%

Pachychoroid disease

Cheung

Lee

Koizumi

et al. 2018

Eye

536

525

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Pachychoroid is a relatively novel concept describing a phenotype characterized by attenuation of the choriocapillaris overlying dilated choroidal veins, and associated with progressive retinal pigment epithelium dysfunction and neovascularization. The emphasis in defining pachychoroid-related disorders has shifted away from simply an abnormally thick choroid (pachychoroid) toward a detailed morphological definition of a pathologic state (pachychoroid disease) with functional implications, which will be discussed in this review. Several clinical manifestations have been described to reside within the pachychoroid disease spectrum, including central serous chorioretinopathy, pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, polypoidal choroidal vasculopathy/aneurysmal type 1 neovascularization, focal choroidal excavation, peripapillary pachychoroid syndrome. These conditions all exhibit the characteristic choroidal alterations and are believed to represent different manifestations of a common pathogenic process. This review is based on both the current literature and the clinical experience of our individual authors, with an emphasis on the clinical and imaging features, management considerations, as well as current understanding of pathogenesis of these disorders within the context of the recent findings related to pachychoroid disease.

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“…We have previously reported outer nuclear layer thinning in eyes with PPE 14. In this study, we aimed to investigate the prevalence of PPE in the fellow eyes ofpatients with unilateral CSC.…”

Section: Introductionmentioning

confidence: 96%

Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy

et al. 2017

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Outer Nuclear Layer Thinning in Pachychoroid Pigment Epitheliopathy

Abstract: The ONL is thinner in eyes with PPE. The degenerative process of pachychoroid spectrum diseases may begin with retinal pigment epithelium alterations before subretinal fluid accumulation. The PPE lesions, commonly seen above pachyvessels, may be an indicator of photoreceptor apoptosis.

Cited by 43 publications

References 21 publications

<p>532-nm Subthreshold Micropulse Laser for the Treatment of Chronic Central Serous Retinopathy</p>

<p>532-nm Subthreshold Micropulse Laser for the Treatment of Chronic Central Serous Retinopathy</p>

Pachychoroid disease

Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy

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