Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit <i>Citrus Χ paradisi</i>: A comprehensive review for maximizing its value

Khalil, Mohammed N.A.; Farghal, Hebatullah H.; Farag, Mohamed A.

doi:10.1080/10408398.2020.1830364

Cited by 22 publications

(19 citation statements)

References 177 publications

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“…Indeed, C. paradisi peel is mainly utilized as biosorbent, while the extracted oil is applied in aromatherapy and its main component, limonene, is used as antimicrobial or in cosmetics sector. Grapefruit pectin is exploited for bioethanol production or as biosorbent, and peel phenolics biotransformation is promoted [ 99 ].…”

Section: Citrus Paradisi Macfadmentioning

confidence: 99%

The Second Life of Citrus Fruit Waste: A Valuable Source of Bioactive Compounds

et al. 2021

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Citrus fruits (CF) are among the most widely cultivated fruit crops throughout the world and their production is constantly increasing along with consumers’ demand. Therefore, huge amounts of waste are annually generated through CF processing, causing high costs for their disposal, as well as environmental and human health damage, if inappropriately performed. According to the most recent indications of an economic, environmental and pharmaceutical nature, CF processing residues must be transformed from a waste to be disposed to a valuable resource to be reused. Based on a circular economy model, CF residues (i.e., seeds, exhausted peel, pressed pulp, secondary juice and leaves) have increasingly been re-evaluated to also obtain, but not limited to, valuable compounds to be employed in the food, packaging, cosmetic and pharmaceutical industries. However, the use of CF by-products is still limited because of their underestimated nutritional and economic value, hence more awareness and knowledge are needed to overcome traditional approaches for their disposal. This review summarizes recent evidence on the pharmacological potential of CF waste to support the switch towards a more environmentally sustainable society.

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Section: Citrus Paradisi Macfadmentioning

confidence: 99%

The Second Life of Citrus Fruit Waste: A Valuable Source of Bioactive Compounds

et al. 2021

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“…Citrus paradisi , or grapefruit, is a subtropical citrus tree known for its fruit. 37 It is traditionally used as a botanical in various forms: whole fruit, juice, extract, essential oil, or dried seed extract. All these derivatives are known for their antioxidant and antimicrobic properties.…”

Section: Resultsmentioning

confidence: 99%

A Practical Perspective on the Use of Botanicals During the COVID-19 Pandemic: From Proven to Potential Interactions

Bertuccioli

Cardinali

Pierro

et al. 2022

Journal of Medicinal Food

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In this review, we examined the top 10 nutraceutical products sold in Italian pharmacies and parapharmacies as well as hypermarkets and supermarkets; in the first, three product categories saw the greatest increase in sales (vitamins and minerals, immunostimulants, and sleep products) for the 12-month period between October 2019 and October 2020 (including first pandemic wave of SARS-CoV-2). We are investigating their respective formulas and isolating the botanicals that are used to make them. Many of these products have undergone preclinical and clinical studies. We performed a systematic literature search in the MEDLINE database using PubMed and Google Scholar from November 15, 2020 to December 15, 2020 (including studies carried out between 1980 and 2020). The search terms that were used included the complete name of the medicinal plant in English or Latin and the terms “cytochrome” or “drug interactions,” crossing, respectively, the Latin name and English common names with “cytochrome” and “drug interactions.” The search included in vitro and in vivo studies describing the effects of interaction between the plant (extract or botanical medicine) and human cytochromes. Despite their great complexity, there is decidedly limited clinical data on botanical medicine. In fact, of the 28 botanicals that were examined, only 2 ( Citrus paradisi and Rhodiola rosea ) show in vivo pharmacological interactions in human subjects. On the contrary, for the other botanicals, there is only weak evidence of dubious clinical significance or potential interactions shown in animal models or in vitro without clinical confirmation. This study provides a rational assessment of the most widely used products, including those used in self-medication, to simplify patient management during the COVID-19 health emergency.

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“…199 Also, nootkatone is suggested as an indicator in evaluating the quality of grapefruit juice and grapefruit oil. 200 In addition, valencene and nootkatone have high variable importance in projection values in partial leastsquares discriminant analysis and thus are chosen as volatile biomarkers for the identification of citrus species. 13 Valencene and nootkatone may also be applied for their bioactives.…”

Section: Applicationsmentioning

confidence: 99%

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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Valencene and nootkatone, two sesquiterpenes, extracted from natural sources, have great market potential with diverse applications. This paper aims to comprehensively review the recent advances in valencene and nootkatone, including source, production, physicochemical and biological properties, safety and pharmacokinetics evaluation, potential uses, and their industrial applications as well as future research directions. Microbial biosynthesis offers a promising alternative approach for sustainable production of valencene and nootkatone. Both compounds exert various beneficial activities, including antimicrobial, insecticidal, antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, hepatoprotective, and nephroprotective and other activities. However, most of the studies are performed in animals and in vitro, making it difficult to give a conclusive description about their health benefits and extend their application. Hence, more attention should be paid to in vivo and long-term clinical studies in the future. Moreover, valencene and nootkatone are considered safe for consumption and show great promise in the applications of food, cosmetic, pharmaceutical, chemical, and agricultural industries.

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Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi: A comprehensive review for maximizing its value

Cited by 22 publications

References 177 publications

The Second Life of Citrus Fruit Waste: A Valuable Source of Bioactive Compounds

The Second Life of Citrus Fruit Waste: A Valuable Source of Bioactive Compounds

A Practical Perspective on the Use of Botanicals During the COVID-19 Pandemic: From Proven to Potential Interactions

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

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