The sloshing effect of fluid storage tanks of a Floating Liquefied Natural Gas (FLNG) vessel causes variations in its global motion response. These acceleration and motion alterations can affect the safe performance of the FLNG vessels. The classification societies’ rules are employed to standardize the storage tanks’ configuration of FLNG vessels. Herein, we report a methodology to assess the sloshing effect on the global motion response of an FLNG vessel considering four geometrical arrangements of tanks and different fluid filling fractions. This methodology includes the hydrodynamic effect in operating and storm conditions from the Gulf of Mexico using a return period of 100 years. In addition, our methodology considers the influence of the internal fluid of each tank to estimate the accelerations and motions of the vessel. This methodology can be implemented to estimate the stability of an FLNG vessel under different environmental conditions. Thereby, the naval engineers could choose the best geometrical configuration of the storage tanks for safe behavior of a vessel under different operating and extreme environmental conditions.