Outline of Occupational Chromium Poisoning in China

Yang, Yuan; Liu, Hong; Xiang, Xianhong; Liu, Fuyou

doi:10.1007/s00128-013-0998-3

Cited by 48 publications

(23 citation statements)

References 16 publications

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“…The high metal levels in human blood have been reported in several previous investigations, which might be attributed to the occupational exposure source (Gil et al 2011;Hodnett et al 2012;Ivanenko et al 2012;Caciari et al 2012;Feki-Tounsi et al 2013a and2013b;Khlifi et al 2013;Khlifi et al 2014a and2014b;Ojo et al 2014;Choi and Kim 2014). Additionally, numerous epidemiological investigations suggested that exposure to toxic metals via occupational exposure has been evermore associated to nasal disease (Yang et al 2013;Sciskalska et al 2014) and sino-nasal cancer (Doll et al 1970;IARC 1990;Barbieri et al 2005;d'Errico et al 2009). …”

Section: Discussionmentioning

confidence: 79%

Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease

Khlifi

Olmedo

Gil

et al. 2014

Environ Sci Pollut Res

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Nasosinusal polyposis (NSP) is a chronic inflammatory disease of the nasal mucosa. Although the pathophysiology underlying NSP formation is not fully understood, environmental factors appear to be contributed the development of this disease. A case-control study of Tunisian patients was examined to assess the levels of cadmium (Cd) and nickel (Ni) in blood and reparse the association between the exposure to these metals and the risk of nasosinusal polyposis disease. Mean blood levels of Cd in patients (2.2 ± 12.8 μg/L) were significantly higher than those of controls (0.5 ± 0.7 μg/L). Levels of blood Cd were positively correlated with tobacco smoking and chewing among controls. The Cd and Ni concentrations among control (p = 0.001) and patient (p = 0.018) tobacco consumers (smoking, chewing, and shisha) were significantly higher than those nonconsumers. Additionally, Ni blood levels of patient and control smokers were significantly higher than those of nonsmokers. Cd levels in blood samples of NSP patients occupationally exposed for more than 14 years were eight times higher than that of nonexposed. Drinking water was also found to be incriminated as exposure sources. Among risk factors, shisha consumption, environmental exposure, and occupational exposure presented the most significant association with NSP disease (odds ratio (OR) = 14.1, 10.1, and 1.7, respectively). High levels of blood Cd (OR = 3.5) were strongly associated with NSP disease (p = 0.027). Ni blood levels were shown to be associated with the four stages of polyps in both nasal cavities (right and left) (p < 0.05). This investigation suggested a potential role of toxic metals in the mechanism of NSP disease development. Exposure assessment investigations encompassing a wider population are needed.

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Section: Discussionmentioning

confidence: 79%

Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease

Khlifi

Olmedo

Gil

et al. 2014

Environ Sci Pollut Res

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“…Epidemiological data indicate that women working in Cr industries or living in Cr-contaminated environments suffer from several gynecological complications including spontaneous abortion [17,18,90]. Occupational exposure to CrVI during pregnancy decreased intrauterine growth of the fetuses, resulting in low birth weight [91].…”

Section: Discussionmentioning

confidence: 99%

“…Occupational exposure to CrVI is found among approximately one-half million industrial workers in the U.S and several millions worldwide [11,12]. Epidemiological data indicate that women working in Cr industries such as textiles and tanneries have high Cr levels in their blood, urine, umbilical cord and placental tissue [13,14], experience abnormal menses [15,16], spontaneous abortion [17,18], and deliver children with developmental defects [19,20], and low birth weight [21]. …”

Section: Introductionmentioning

confidence: 99%

Chromium VI − Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins

Banu

Stanley

Sivakumar

et al. 2017

Reproductive Toxicology

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Environmental contamination with hexavalent chromium (CrVI) is a growing problem both in the U.S and developing countries. CrVI is a heavy-metal endocrine disruptor; women working in Cr industries exhibit an increased incidence of premature abortion and infertility. The current study was designed to understand the mechanism of CrVI toxicity on placental cell survival/death pathways. Pregnant mothers were treated with or without CrVI (50 ppm K2Cr2O7) through drinking water from gestational day (GD) 9.5–14.5, and placentas were analyzed on GD 18.5. Results indicated that CrVI increased apoptosis of trophoblasts, vascular endothelium of the metrial glands and yolk sac epithelium through caspase-3 and p53-dependent pathways. CrVI increased apoptosis in labyrinth and basal zones in a caspase-3-independent manner via AIF, and through an ATM-p53-NOXA-PUMA-p27 network. CrVI downregulated cell survival proteins Bcl-2, Bcl-XL and XIAP in the placenta. CrVI disrupts placental histoarchitecture and increases cell death by spatiotemporal modulation of apoptotic signaling.

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“…Similar to animal studies, these found: increased spontaneous abortions [37]; decreased intrauterine growth of fetuses resulting in low birth weight [38, 39]; high levels of Cr(VI) in the blood, urine, and umbilical cord blood [38, 40]; and in neonates, Cr(VI) in the cord blood and cord lymphocyte mutations [32, 41]. …”

Section: Introductionmentioning

confidence: 65%

Reproductive outcomes after non-occupational exposure to hexavalent chromium, Willits California, 1983-2014

2017

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BackgroundFrom 1963–1995, a factory in Willits, Mendocino County, CA used toxic hexavalent chromium (Cr(VI)) without adequate measures to protect the population. We use longitudinal hospital data to compare reproductive outcomes for two generations in Willits and two generations in the Rest of County (ROC). This is the first study to quantify the reproductive impact of Cr(VI) in a non-occupational population.MethodsWe searched California hospital discharge data (1983–2014) to find Mendocino County residents born 1950 or later. ZIP-code 95490 identifies Willits residents, with all others living in ROC. We used the Multi-Level Clinical Classification Software (CCS) to classify health outcomes.First, we calculated the crude birth rate using an external census denominator. The next two models used self-contained denominators to assess health of infants and two generations of pregnant women. Finally, we focused on non-pregnant females and, for comparison, males. Here we added admissions for people who moved, linked and summarized admissions to the person level, and calculated rates per census population.ResultsWe found 29311 newborn records in ROC and 5036 from Willits. At start of period, Willits birth rate was low and did not recover until 12 years after Plant closure. While the Plant was open, respiratory conditions, perinatal jaundice, and birth defect rates were higher for Willits infants compared to ROC, but improved post-closure. Risk for abnormal birthweight and term was high and remained high over the study period.During the period under study, we identified 31444 admissions of pregnant ROC women and 5558 from Willits. Willits women had significantly higher risk of pregnancy loss compared to ROC, whether stratified by generation, age group, or pre- and post-closure. Regardless of when exposed, Willits women continued to have significantly higher rates of in-hospital terminations, as animal studies of Cr(VI) exposure predict. In life course models, non-pregnant Willits women have significantly higher risk of reproductive organ conditions and neoplasms compared to ROC.ConclusionsAdverse reproductive outcomes are elevated and consistent with animal studies. General health outcomes reflect the same broad effect reported for occupationally exposed workers. For the first time, the detrimental reproductive effects of non-occupational Cr(VI) exposure in human females and their infants is reported.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0222-8) contains supplementary material, which is available to authorized users.

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Outline of Occupational Chromium Poisoning in China

Cited by 48 publications

References 16 publications

Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease

Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease

Chromium VI − Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins

Reproductive outcomes after non-occupational exposure to hexavalent chromium, Willits California, 1983-2014

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