Outpatient transfusions and occurrence of serious noninfectious transfusion‐related complications among US elderly, 2007‐2008: utility of large administrative databases in blood safety research

Menis, Mikhail; Izurieta, Héctor S.; Anderson, Steven A.; Kropp, Garner; Holness, Leslie; Gibbs, Jonathan; Erten, Tugce; Worrall, Chris; MaCurdy, Thomas; Kelman, Jeffrey A.; Ball, Robert

doi:10.1111/j.1537-2995.2011.03535.x

Cited by 27 publications

(20 citation statements)

References 37 publications

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“…congestive heart failure, cardiac arrhythmias, hypertension), suggest potential importance of underlying immunity among the elderly for FNHTR occurrence, which needs further clinical evaluations. In support of the literature, our study also suggests FNHTR to be one of the most frequent transfusion‐related adverse events among the elderly . As such, physicians should be aware of FNHTR occurrence among the elderly, which results in patient discomfort and therapeutic intervention.…”

Section: Discussionsupporting

confidence: 82%

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

et al. 2014

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Section: Discussionsupporting

confidence: 82%

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

et al. 2014

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“…Menis et al's study [13] shows potential usefulness of databases in assessment of blood utilization, transfusion-related complication, and risk factors among United States' elderly in the outpatient setting. Our study is the first one that surveys blood transfusions reactions in a geriatric inpatient setting.…”

Section: Discussionmentioning

confidence: 99%

Blood Transfusion Reactions in Elderly Patients Hospitalized in a Multilevel Geriatric Hospital

Lubart

Segal

Tryhub

et al. 2014

Journal of Aging Research

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Background/Objectives. Blood transfusion is a critical issue for patients with chronic diseases such as heart failure, chronic kidney disease, and malignancy. However, side effects are not rare. The purpose of the study is to evaluate the frequency of adverse blood transfusion reactions in hospitalized elderly patients during a one-year period. Design/Setting/Participants. Blood transfusion reactions such as fever, chills, dyspnea, and others following blood transfusions in hospitalized geriatric patients during one-year period were examined. Results. 382 blood units (242 patients) were administered during the study period. In 40 (11%) cases, blood transfusion reactions occurred. Fever was the most common reaction in 29 cases (72%), four (10%) had shortness of breath, and 3 (8%) had vomiting and chills each. There were no lethal cases in the 24-hour period following blood transfusions. Conclusion. A relatively low rate of adverse blood transfusion reactions occurred in our geriatric patients. We may speculate that this is related to underreporting of minor symptoms due to the high percentage of demented patients in this population.

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“…Thus there exists the potential for hemolysis following the transfusion of an ABO-minor mismatched PLT unit if the titer of the incompatible antibody is sufficiently high. A recent retrospective analysis of the Medicare database in the USA revealed that in 3 out of 59,933 PLT transfusions the transfusion of ABO incompatible PLTs led to an unspecified ‘adverse event', suggesting that hemolysis due to ABO-minor mismatched PLT transfusions is a rare occurrence [2]. Several investigations into the titers of donor anti-A and anti-B antibodies in both apheresis and whole blood PLT products have been performed.…”

Section: Part 1: Plt Transfusion and Abo Compatibilitymentioning

confidence: 99%

Platelet Transfusion - the Art and Science of Compromise

Cid

Harm

Yazer

2013

Transfus Med Hemother

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Many modern therapies depend on platelet (PLT) transfusion support. PLTs have a 4- to 7-day shelf life and are frequently in short supply. In order to optimize the inventory PLTs are often transfused to adults without regard for ABO compatibility. Hemolytic reactions are infrequent despite the presence of ‘high titer' anti-A and anti-B antibodies in some of the units. Despite the low risk for hemolysis, some centers provide only ABO identical PLTs to their recipients; this practice might have other beneficial outcomes that remain to be proven. Strategies to mitigate the risk of hemolysis and the clinical and laboratory outcomes following ABO-matched and mismatched transfusions will be discussed. Although the PLTs themselves do not carry the D antigen, a small number of RBCs are also transfused with every PLT dose. The quantity of RBCs varies by the type of PLT preparation, and even a small quantity of D+ RBCs can alloimmunize a susceptible D- host. Thus PLT units are labeled as D+/-, and most transfusion services try to prevent the transfusion of D+ PLTs to D- females of childbearing age. A similar policy for patients with hematological diseases is controversial, and the elements and mechanisms of anti-D alloimmunization will be discussed.

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Outpatient transfusions and occurrence of serious noninfectious transfusion‐related complications among US elderly, 2007‐2008: utility of large administrative databases in blood safety research

Cited by 27 publications

References 37 publications

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

Blood Transfusion Reactions in Elderly Patients Hospitalized in a Multilevel Geriatric Hospital

Platelet Transfusion - the Art and Science of Compromise

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