Electric power systems have experienced the rapid insertion of distributed renewable generating sources and, as a result, are facing planning and operational challenges as new grid connections are made. The complexity of this management and the degree of uncertainty increase significantly and need to be better estimated. Considering the high volatility of photovoltaic generation and its impacts on agents in the electricity sector, this work proposes a multivariate strategy based on design of experiments (DOE), principal component analysis (PCA), artificial neural networks (ANN) that combines the resulting outputs using Mixture DOE (MDOE) for photovoltaic generation prediction a day ahead. The approach separates the data into seasons of the year and considers multiple climatic variables for each period. Here, the dimensionality reduction of climate variables is performed through PCA. Through DOE, the possibilities of combining prediction parameters, such as those of ANN, were reduced, without compromising the statistical reliability of the results. Thus, 17 generation plants distributed in the Brazilian territory were tested. The one-day-ahead PV generation forecast has been considered for each generation plant in each season of the year, reaching mean percentage errors of 10.45% for summer, 9.29% for autumn, 9.11% for winter and 6.75% for spring. The versatility of the proposed approach allows the choice of parameters in a systematic way and reduces the computational cost, since there is a reduction in dimensionality and in the number of experimental simulations.