Ovarian Cancer

Cho, Kathleen R.; Shih, Ie‐Ming

doi:10.1146/annurev.pathol.4.110807.092246

Cited by 642 publications

(639 citation statements)

References 128 publications

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“…[9][10][11][12] The classification of ovarian epithelial tumors currently used by pathologists is based entirely on tumor cell morphology, architectural pattern, nuclear atypia and stromal invasion. 8,13,14 The cell type may be serous, mucinous, endometroid, Brenner/transitional, clear cell and undifferentiated. These cell types bear strong resemblance to the normal cell lining of different organs in the female genital tract.…”

Section: Peritoneal Implant 11mentioning

confidence: 99%

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Ghartimagar

Ghosh

et al. 2013

J Pathol Nep

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Background: Ovarian cancer accounts for 3% of all cancers in females. About 80% of these are benign, and they occur mostly in young women between 20 and 45 years. Borderline tumors occur at slightly older ages while incidence of malignant tumors increases with age, occurring predominantly in perimenopausal and postmenopausal women. About 190,000 new cases and 114,000 deaths from ovarian cancer are estimated to occur annually worldwide. The aim of the study was to fi nd the incidence of surface ovarian tumor in a tertiary referral centre. Materials and methods: This was a retrospective study carried out in the department of pathology, Manipal Teaching Hospital from January 2001 to December 2012. Specimens were received from the same and other hospitals. Records were retrieved from the departmental data bank and were analyzed. Results: : A total of 310 cases of ovarian tumors have been reported in the same period. Among them, 180 cases were of surface epithelial origin and out of which 24 cases had bilateral tumors. Benign tumors comprised of 148 cases, 6 were borderline and 44 were malignant. Among these, the commonest was serous cystadenoma (98 cases) and the least common was malignant Brenner (2 cases). Combined or mixed tumor was seen in 9 cases. Conclusion: : In our study surface epithelial tumors comprised 58% of all ovarian tumors. In both benign and malignant cases, serous tumor was the commonest followed by mucinous tumors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 397-402 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7868

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Section: Peritoneal Implant 11mentioning

confidence: 99%

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Ghartimagar

Ghosh

et al. 2013

J Pathol Nep

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“…A number of studies have demonstrated that the halflife of mutated p53 (several hours) is markedly increased compared to wild-type (several minutes) which may result in its accumulation in the cell nucleus and the accumulation of protein rather than the mutations has been suggested as the immunogenic trigger that results in autoantibody generation [17]. Clinicopathological and molecular studies suggest that ovarian carcinoma can be divided in two broad categories, "Type I" and "Type II" tumors [8]. The terms, "Type I" and "Type II"…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Ovarian cancer when diagnosed in early stages results in over 90% 5-year survival rate, however if diagnosed in late stage this drops to only 30% 5-year survival rate [8].…”

Section: Introductionmentioning

confidence: 99%

Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays

Murphy

O’Connell

O’Kane

et al. 2012

Journal of Proteomics

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* These authors contributed equally.Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis may facilitate detection of ovarian cancer in the early stages of the disease with identification of a panel of tumour specific autoantibodies. Despite the reporting of many tumour associated autoantibodies using arrays of tumour antigens, this has not led to the advance in diagnostic capability as rapidly as was initially expected. Here we examine the potential diagnostic utility of candidate autoantibody biomarkers identified via screening of serum samples on a high content human protein array from a unique cohort of early stage and late stage ovarian cancer patients. We analyse the performance of autoantibodies to the tumour suppressor protein p53 and the novel autoantigens alpha adducin and endosulfine alpha identified in our array screen. Each antigen has different performance characteristics using conventional ELISA format and Western blot immunoassay. The high attrition rate of promising autoantigens identified by array screening can in part be explained by the presentation of the epitope of the antigen in the subsequent method of validation and this study provides directions on maximising the potential of candidate biomarkers. The most commonly used biomarker for ovarian cancer is Cancer Antigen 125 (CA125) or Mucin16 which is thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces [9]. Elevated levels of this antigen are detected in over 90% of sera of disseminated ovarian cancer cases but only in 50% of patients in the early stages of the disease [10]. CA 125 screening is used with the addition of ultrasound screening. Although these combined approaches A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Materials and Methods Serum Sample DetailsSerum samples and clinical information was obtained with informed consent and study approval was obtained from St. James's Hospital and Adelaide and Meath incorporating the National Childerns Hospital research ethics committee.Pre-operative bloods were obtained from patients undergoing cytoreductive surgery for possible ovarian neoplasm. Blood was collected into a non-heparinised tube and allowed to clot, then centrifuged at 400 x g for 15 min. The serum supernatant was removed and dispensed into labelled cryovial tubes. Serum was stored at -80 o C until further use. hEx1 Serum Screening of Ovarian Cancer SamplesThe hEx1 array PVDF membranes (each hEx1 array is made up of 2 PVDF membranes, pt 8 and pt 9) were activated in ethanol for 1 min, rinsed in deionised water and washed in tris-buffered saline-T-T (500mM NaCl, 10mM Tris-HCl pH 7.5, 0.05% v/v Tween, 0.5% v/v Triton X ). Dessicated bacterial colonies were removed with tissue. The arrays washed in TBS-T-T for 10 min, TBS-T (500mM NaCl, 10mMTris-HCl pH 7.5, 0.05% v/v Tween) for 10 min and TB...

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confidence: 98%

Endoscopic ultrasound, GIST, and ovarian cancer

Araújo

Castro-Poças

Santos

et al. 2014

Int J Colorectal Dis

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Dear Editor: Ovarian carcinoma is the most lethal gynecological cancer [1], and the endometrioid type accounts for 7-20 % of all cases [2]. The gastrointestinal stromal tumor (GIST) may mimic ovarian tumors, as reported previously by other authors [3,4]. We present a case report of a GIST mimicking an ovarian carcinoma.A 67-year-old female underwent a colonoscopy for colon cancer screening. It showed a submucosal lesion, covered with normal appearance mucosa. An endoscopic ultrasonography showed between 4 and 14 cm from the anal margin, with the greatest transverse diameter of 42.5 by 32.7 mm, a heterogeneous lesion, hypoechoic, with slightly irregular borders, originated in the muscular layer; the luminal board counter presented itself closely adjacent to an ovary, where it was identified as a cystic lesion, and a loss of the cleavage plane. We identified a perilesional, oval, hypoechoic adenopathy, with a diameter of 11 by 5.2 mm. We suspected of a GIST or an extraintestinal tumor involving the rectum. An endoscopic ultrasonography (EUS) with fine needle (19G) aspiration with collection of sampling for histology and cytology revealed highgrade undifferentiated neoplasm suggestive of ovarian carcinoma, CD117 negative.She underwent a surgery that confirmed an endometrioid ovarian carcinoma, invading the rectum. Subsequently, the patient has started chemotherapy with carboplatin and paclitaxel and is still on treatment.Besides, there have been reported a case of primary epithelial ovarian carcinoma with gastric metastasis mimicking GIST, but to our best knowledge, there have not been reported an ovarian cancer mimicking a rectal GIST.We emphasize the high accuracy of EUS in the correct characterization of the lesion and its anatomical relations and the possibility of collecting a sample that confirms the diagnosis, allowing a more guided surgery.

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Ovarian Cancer

Cited by 642 publications

References 128 publications

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays

Endoscopic ultrasound, GIST, and ovarian cancer

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