Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Ghartimagar, Dilasma; Ghosh, Arnab; Kc, Geetika; Ranabhat, Sabin; Talwar, OP

doi:10.3126/jpn.v3i5.7868

Cited by 8 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common tumors were benign serous tumors accounting for 90 % of the serous surface epithelial tumors and 44.9 % of all surface epithelial tumors, mostly presenting in females of the reproductive age group. However our study is almost consistent with the findings of study done by Ghartimagar et al which showed an incidence of benign serous surface epithelial tumors 49.4 % among of all surface epithelial tumors [ 8 ].…”

Section: Discussionsupporting

confidence: 93%

Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

et al. 2016

View full text Add to dashboard Cite

BackgroundOvarian cancer is the most lethal gynecologic malignancy and it represents third most common malignancy in Karachi (after breast and oral cancer). Due to lack of well established cancer registry in our country, changing trends of ovarian tumors has not been determined. Therefore we aimed to establish the current trends and classification of ovarian tumors in our setup according to latest WHO guidelines.MethodsWe retrospectively analyzed 162 cases of ovarian tumors that underwent surgical resection from January 2009 till December 2014. Specimens were received in histopathology department, Liaquat National hospital and cases were examined by senior histopathologists and classified according to latest WHO guidelines. Various histopathologic parameters including capsular invasion, omental and lymph node meatstasis along with uterine and fallopian tube involvement were determined apart from tumor type and grade.ResultsMean age at diagnosis was 35.8 years (± 15.5). surface epithelial tumors were most common, 109 cases (67.2 %) followed by germ cell tumors, 44 cases (27.1 %) and sex cord stromal tumors, 8 cases (4.9 %). Serous tumors were most common surface epithelial tumors with 90 % benign morphology. On the other hand, mucinous tumors showed a higher percentage of borderline and malignant features (16.7 and 14.6 % respectively). Higher incidence of capsular invasion and omental metastasis was noted in endometroid and serous carcinoma compared to mucinous tumors.ConclusionsWe noted a higher frequency of young age ovarian cancers in our set up. Serous and endometroid carcinomas were found to be associated with adverse prognostic factors like capsular invasion and omental metastasis. Moreover a significantly higher proportion of ovarian tumors constitute mucinous histology including borderline tumors. Whether this represents a changing trend towards biology of these tumors in this part of the world needs to be uncovered by further studies.

show abstract

Section: Discussionsupporting

confidence: 93%

Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

et al. 2016

View full text Add to dashboard Cite

show abstract

“…[13][14][15] It has been reported previously that benign EOT occur in younger age groups, the borderline tumours in the fourth to fifth decades and malignant in older ages beyond the sixth decade of life. [16 ] The findings from the present study confirmed this tendency and it appears that there is an age proportion for benign, borderline and malignant EOTs all over the world. The benign EOTS affect younger women with many cases diagnosed between the second and the third decades of life; the borderline tumours affect relatively older ages in the sixth decade while malignant cases occur in much older patients in this environment.…”

Section: Discussionsupporting

confidence: 86%

Clinicopathologic characteristics of epithelial ovarian tumours in Ile-Ife, Nigeria

Go¹,

Odujoko²,

Anjorin³

2020

Ann Health Res

View full text Add to dashboard Cite

Background: Epithelial ovarian tumours (EOT) have complex clinicopathologic characteristics and biological behaviours. There are benign, borderline and malignant ovarian tumours and the commonest ovarian tumours in many regions are of epithelial origin. Many studies have described the histomorphological characteristics of the tumours. Objective: To describe the clinical and histopathological features of epithelial ovarian tumours. Methods: This was a retrospective review of the histopathology reports of all epithelial ovarian tumours specimens submitted to the Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife from January 2005 to December 2014. The EOT cases were described in terms of age, clinicopathological characteristics and distribution of histological types. Results: The frequencies of benign, borderline and malignant EOTs were 41.2%, 3.9% and 54.9% respectively and the patients were aged 23 to 94 years (mean 46.5±2.6 years). The majority of cases were often asymptomatic. Conclusion: Abdominal swelling was the most common presenting complaint while serous ovarian tumours were the most preponderant histological types.

show abstract

“…Ghartimagar D et al noted age ranging from 13 to 90 years in their study of 310 cases of ovarian tumors. [9] Chhanda Das et al reported 5 to 62 years in their study of 50 cases of ovarian neoplasms which was similar to other studies. [6,10] Most benign tumors occurred in the age range of 21 to 50 years that was consistent with other studies.…”

Section: Discussionsupporting

confidence: 83%

Immunohistochemical Study of CA 125 in Surface Epithelial Tumors of Ovary in Correlation with Serum Levels

Pillarisetty

Ravindra

2020

Ann of Pathol and Lab Med

View full text Add to dashboard Cite

Background: Ovarian carcinoma is the 4th leading cancer among women in India. Primary ovarian neoplasms exhibit a wide range of histopathological patterns and tumors with epithelial differentiation are most frequent. Among malignant tumors, most common histological type is serous adenocarcinoma whose diagnosis is established in advanced stages of disease in approximately 75% of patients. The most widely used tumor marker in ovarian cancer, often considered “gold standard” is Cancer Antigen125. Cancer Antigen 125 is a high molecular weight glycoprotein which is raised in approximately 90% of patients with advanced epithelial ovarian cancer. Methods: A 2 year prospective study included 81 cases of ovarian neoplasms with surface epithelial differentiation. The specimens were fixed in 10% formalin, routinely processed. Sections of 4-5 microns thickness were obtained from the paraffin block and stained with Hematoxylin & Eosin. The tumors were categorised according to WHO classification. Immunohistochemical analysis of Cancer Antigen 125 was done in all malignant & borderline tumors. Result: A total of 81 cases were studied. There were 15 cases with elevated serum Cancer Antigen 125 levels. Of these 8 showed positive tissue expression. The sensitivity of serum Cancer Antigen 125 was 68.75% & its specificity was 93.8%. Conclusion: Serum Cancer Antigen 125 is elevated in ovarian tumors especially in malignant surface epithelial tumors & more commonly in serous cystadenocarcinoma. There was a good correlation between serum levels & tissue expression of Cancer Antigen 125.

show abstract

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Cited by 8 publications

References 14 publications

Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

Clinicopathologic characteristics of epithelial ovarian tumours in Ile-Ife, Nigeria

Immunohistochemical Study of CA 125 in Surface Epithelial Tumors of Ovary in Correlation with Serum Levels

Contact Info

Product

Resources

About