Ovarian cancer and Mayer–Rokitansky–Kuster–Hauser syndrome

Abstract

48-year-old woman with Mayer-RokitanskyKuster-Hauser (MRKH) syndrome, right kidney aplasia, a pelvic-abdominal mass, and an elevated CA-125 level underwent bilateral salpingo-oophorectomy, omentectomy, and debulking for a presumed ovarian carcinoma. Intraoperative findings included a pelvic tumor on the surface of both ovaries. Pathological examination revealed a poorly differentiated ovarian carcinoma, mixed type, mainly of transitional and serous types, with minor components of clear cell and mucinous patterns. A stage III ovarian epithelial carcinoma, mixed type was diagnosed. The patient was treated with Paclitaxel and Carboplatin and was asymptomatic 24 months postoperatively. Rarely, ovarian carcinoma may be associated with MRKH syndrome.

Co-occurrence of Mayer-Rokitansky-Küster-Hauser syndrome and ovarian cancer: A case report and review of the literature

“… Article Country MRKHS type Ovarian tumor age at onset Ovarian tumor histology Ovarian tumor type Ovarian tumor grade Ovarian tumor stage (FIGO) ( Koonings et al, 1991 ) United States I 26 Germ cell Yolk sac tumor a na I ( Larsen et al, 1992 ) Canada II 34 Sex-cord stromal Sertoli cell b II I ( Pommerenke et al, 1994 ) Germany II 79 Sex-cord stromal Bilat. Sertoli cell II na ( Tsaur et al, 1995 ) China I 4 Germ cell Immature teratoma II I ( Ghirardini and Magnani, 1995 ) Italy I 68 Epithelial Undifferentiated carcinoma III III ( Takeuchi et al, 2006 ) Japan na 8 Germ cell Yolk sac tumor na I ( Mishina et al, 2007 ) Moldova na 35 Germ cell Dysgerminoma na I ( Kavallaris et al, 2011 ) Germany II 48 Epithelial Mixed epithelial carcinoma III III ( Bae et al, 2013 ) Korea …”