Ovarian Cancer;

Abstract

Object: 1). To analyze of serum tumor marker CA-125 in patients with ovarian malignant tumors. 2). To correlate betweenthe serum levels of tumor marker with histological types of ovarian malignant tumors. Study Design: Institution based descriptive andprospective study. Place & Duration: Department of Pathology, Liaquat University of Medical & Health Sciences, Jamshoro from January2009 to June 2011. Material & Methods: One hundred cases, diagnosed as ovarian malignant tumor on H&E staining were selected forstudy & measure serum CA-125 preoperatively and postoperatively in each case. Results: Out of 100 cases diagnosed as on H&E stainwere 33 serous cystadenocarcinoma, 24 mucinous adenocarcinoma, 10 germ cell tumors and 08 sex-cord stromal tumors. On serumanalysis increased level of CA-125 was seen preoperatively in 33/33 cases of serous cystadenocarcinoma and 24/29 cases of mucinousadenocarcinoma. Serum tumor marker value was declined following appropriate therapy of the tumors. Conclusions: Serum tumormarkers CA-125 is useful and important for the detection of ovarian tumors. It is most significant for serous cystadenocarcinoma. It mayalso help in prognosis and specific treatment of ovarian malignancies relating to histological type.

Correlation of raised serum CA-125 level with laparotomy and histopathology findings of ovarian tumour in a tertiary level hospital

“…Deeba F et al have showed raised serum CA-125 was found 78.6% of ovarian cancer [20] . Shaikh NA et al observed that serum CA-125 level is not only raised in epithelial ovarian cancer but also in germ cell & sex cord stromal tumours while in this study 10.5% of germ cell tumour serum CA-125 was raised [17] . In this study it was observed that serum CA-125 significantly raised in most of the malignant ovarian tumours (68.4%).…”

“…CA 125 levels of <35 U/ml are accepted as normal. Elevated levels were found in more than 90% of advanced epithelial ovarian cancer but only 50% in stage I disease [17] . It is also slightly increase in endometriosis & markedly increase in ovarian tumour.…”

Association between Histopathologic Type of Ovarian Cancer and Serum CA-125 Level

“…The findings of the present study are in concurrence with other studies. [12][13][14] In another study, it was found that prevalence of serous ovarian cancer was very high in European population followed by American then Asian population. 15 Most of the patients belonged to middle or upper socioeconomic class, were married and were homemakers.…”