Ovarian Choriocarcinoma with Concurrent Metastases to the Spleen and Adrenal Glands: First Case Report

Ramarajapalli, Manjunath Laxmayya; Rao, Nitin A R; Murudaraju, Prathima; Kilara, Nalini

doi:10.1089/gyn.2011.0052

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…The most common form of choriocarcinoma is gestational, arising from the trophoblast of any type of gestational event. It follows a hydatidiform mole, normal pregnancy or spontaneous abortion in decreasing frequency [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature

et al. 2018

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Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Computed tomography (CT) revealed widespread metastatic disease involving the lungs, liver, pancreas, and breast. Serum β-human chorionic gonadotropin was markedly raised. Over 72 h, she deteriorated and was started on high-flow nasal cannula to facilitate discussions and for comfort. Histology from a breast biopsy suggested a choriocarcinoma, and she was commenced on etoposide and cisplatin. Unfortunately she continued to deteriorate and died on day 11 of admission. Molecular genotyping received post-mortem confirmed non-gestational choriocarcinomatous differentiation within a high-grade tumour. Discussion: NGCC carries a worse prognosis compared with gestational choriocarcinoma and is historically less chemosensitive. However, differentiation between these two diagnoses is challenging due to a lack of immuno-histochemical differences. The NGCC in this case was likely to have originated in the lung due to a 12-cm mass in the lingula, and extensive emphysema on CT. Primary pulmonary choriocarcinoma has a rapidly fatal course in the majority of patients. Conclusion: This is the only case to our knowledge of NGCC presenting in extremis, where an accurate diagnosis was not achieved pre-mortem. This also demonstrates the merit of non-invasive ventilation within palliation to facilitate communication and comfort.

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Section: Discussionmentioning

confidence: 99%

Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature

et al. 2018

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“…It can occur after a spontaneous abortion in 25% of cases and after the normal pregnancy in 22.5%. [ 1 5 ] Rarely, it may follow ectopic pregnancy and may arise from the ovaries. The tumor is characterized by the presence of two cell lines: The cytotrophoblast, the cells of which lie in sheets to form villus-like structures, and the syncytiotrophoblast, which secretes beta-human chorionic gonadotropin and human placental lactogen and is seen at the advancing edge of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian choriocarcinoma with concurrent metastases to spleen and adrenal gland undergoing successful treatment is extremely rare, and this is the only one case, reported in the literature. [ 5 ] The tumor has a marked tendency to metastasize early by blood-borne dissemination, to the lungs (80%), pelvis (20%), vagina (30%), liver (10%) and other rare sites including gastrointestinal tract, spleen and kidney. The central nervous system is seldom involved in the absence of pulmonary metastases.…”

Section: Discussionmentioning

confidence: 99%

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A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature

Rao

Konar

Gangadharan

et al. 2015

Journal of Neurosciences in Rural Practice

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Choriocarcinoma is the most malignant tumour of gestational trophoblastic origin. Most ovarian choriocarcinomas are gestational in origin and usually metastasize to the ovary from uterine or tubal choriocarcinoma. Non gestational choriocarcinoma (NGOC) of the ovary is exceedingly rare and usually seen along with other germ cell tumors. Non gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma. We are reporting long term follow up of published rare case of pure non gestational ovarian choriocarcinoma (NGOC) with concurrent metastases to the spleen and adrenal glands, who developed a delayed solitary brain metastases, two years after completion of primary treatment. Surgery along with triple agent chemotherapy and radiotherapy was found to give good remission in this aggressive disease.

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Oral etoposide for metastatic choriocarcinoma: a case report and review of guidelines

Breitbach

Sklavounos

Veith

et al. 2018

Arch Gynecol Obstet

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Ovarian Choriocarcinoma with Concurrent Metastases to the Spleen and Adrenal Glands: First Case Report

Cited by 6 publications

References 7 publications

Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature

Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature

A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature

Oral etoposide for metastatic choriocarcinoma: a case report and review of guidelines

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