Ovarian hemangioma?report of three cases and review of the literature

Uppal, Shweta; Heller, Debra S.; Majmudar, Bhagirath

doi:10.1007/s00404-003-0584-8

Cited by 26 publications

(33 citation statements)

References 13 publications

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“…These are differentiated from cavernous hemangiomas, which commonly involve deeper structures and do not spontaneously regress. Hemangiomas have previously been reported in a variety of endocrine organs, including thyroid [2,3], ovaries [4,5], and adrenal glands [6,7]. To our knowledge, only three previous cases have been reported in the parathyroid, all of which presented in abnormal parathyroid glands from patients with clinical history of hyperparathyroidism [8,9].…”

Section: Introductionmentioning

confidence: 63%

Parathyroid Hemangioma: A Case Report in Proof of its Existence

2011

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Hemangiomas are benign vascular tumors that are most commonly found superficially in the head and neck. Cavernous hemangiomas are located in deeper structures and have been reported in a variety of endocrine tumors. However, parathyroid hemangiomas are exceedingly rare, with only three previously reported cases in the literature, all of which were associated with hyperparathyroidism. Here, we present the first case of an intraparenchymal cavernous hemangioma of the parathyroid gland without accompanying hyperparathyroidism in an otherwise unremarkable gland, accompanied by a brief review of the relevant literature.

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Section: Introductionmentioning

confidence: 63%

Parathyroid Hemangioma: A Case Report in Proof of its Existence

2011

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“…Thus, Tet-mev-1 mice show excessive intracellular oxidative stress, presumably because they are chronically subject to elevated levels of superoxide anion from mitochondrial complex II owing to the SDHC V69E mutation. Given this, it is not surprising that the Tet-mev-1 ovaries were swollen and vacuolated with increased angiogenesis such as ovarian hemangiomas [25], as well as increased apoptosis detected as TUNEL-positive cells in ovarian interstitial cells (Fig. 2C).…”

Section: Resultsmentioning

confidence: 99%

Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion

et al. 2014

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Historical data in the 1950s suggests that 7%, 11%, 33%, and 87% of couples were infertile by ages 30, 35, 40 and 45, respectively. Up to 22.3% of infertile couples have unexplained infertility. Oxidative stress is associated with male and female infertility. However, there is insufficient evidence relating to the influence of oxidative stress on the maintenance of a viable pregnancy, including pregnancy complications and fetal development. Recently, we have established Tet-mev-1 conditional transgenic mice, which can express the doxycycline-induced mutant SDHCV69E transgene and experience mitochondrial respiratory chain dysfunction leading to intracellular oxidative stress. In this report, we demonstrate that this kind of abnormal mitochondrial respiratory chain-induced chronic oxidative stress affects fertility, pregnancy and delivery rates as well as causes recurrent abortions, occasionally resulting in maternal death. Despite this, spermatogenesis and early embryogenesis are completely normal, indicating the mutation's effects to be rather subtle. Female Tet-mev-1 mice exhibit thrombocytosis and splenomegaly in both non-pregnant and pregnant mice as well as placental angiodysplasia with reduced Flt-1 protein leading to hypoxic conditions, which could contribute to placental inflammation and fetal abnormal angiogenesis. Collectively these data strongly suggest that chronic oxidative stress caused by mitochondrial mutations provokes spontaneous abortions and recurrent miscarriage resulting in age-related female infertility.

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“…The occurrence of ovarian hemangioma in a patient treated with tamoxifen has never been reported in the literature. Ovarian hemangiomas are very rare and histologically may be cavernous or capillary with the first type being the most common [1]. The difference between them relates to the size of the blood vessels formed.…”

Section: Discussionmentioning

confidence: 97%

“…Ovarian hemangiomas may occur in association with generalized hemangiomatosis or as an isolated neoplasm. While in the first case, patients have an high risk of intravascular coagulation and Kasabach-Merritt syndrome [1], isolated hemangiomas are usually incidental findings due to their small size and asymptomatic nature. We report a case of ovarian hemangioma in a patient treated with tamoxifen for breast ductal carcinoma.…”

Section: Introductionmentioning

confidence: 98%

Ovarian hemangioma associated with tamoxifen therapy: a case report

Lanzafame

Caltabiano

Nicolosi³

et al. 2007

Gynecol Surg

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Vascular tumors of the ovary are very rare. We report a case of ovarian hemangioma in a patient treated with tamoxifen for breast ductal carcinoma. CD31 and CD34 immunoreactivity confirmed the vascular origin of the tumor. It is interesting to note that estrogen and progesterone receptors were negative in endothelial cells of the hemangioma, but were positive in stromal ovarian cells. Tamoxifen is a synthetic, non-steroidal, anti-estrogenic drug widely used as adjuvant therapy for pre-and postmenopausal, early and metastatic, breast cancer patients with positive estrogen receptor proteins. The mechanism of action of tamoxifen in stimulating the development and/ or growth of ovarian hemangioma is unknown. We may speculate that its prolonged, estrogenic effect on the ovary may be one of the stimulating factor.

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Ovarian hemangioma?report of three cases and review of the literature

Cited by 26 publications

References 13 publications

Parathyroid Hemangioma: A Case Report in Proof of its Existence

Parathyroid Hemangioma: A Case Report in Proof of its Existence

Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion

Ovarian hemangioma associated with tamoxifen therapy: a case report

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