We report a case of bilateral ovarian ossifications with images that mimic stone formations. A 65-year-old woman presented with a 2-year history of pelvic pain. Computed tomographic scan and pelvic ultrasound identified an enlarged uterus with two calcified lesions interpreted as leiomyomas. Surgical exploration revealed two ovaries with a cystic appearance and stony hard areas. The cyst contents consisted of chocolate-colored material. The pathologic findings were compatible with benign bilateral ovarian endometriotic cysts with extensive ossification. The pelvic pain resolved completely after the surgery. Though the cause of this rare case remains unknown, recognition of cysts with a content of chocolate-colored material and pigment-laden histiocytes allowed us to make the diagnosis of bilateral ovarian endometriotic cysts with extensive ossification. Complete excision was the treatment of choice.

Vascular tumors of the ovary are very rare. We report a case of ovarian hemangioma in a patient treated with tamoxifen for breast ductal carcinoma. CD31 and CD34 immunoreactivity confirmed the vascular origin of the tumor. It is interesting to note that estrogen and progesterone receptors were negative in endothelial cells of the hemangioma, but were positive in stromal ovarian cells. Tamoxifen is a synthetic, non-steroidal, anti-estrogenic drug widely used as adjuvant therapy for pre-and postmenopausal, early and metastatic, breast cancer patients with positive estrogen receptor proteins. The mechanism of action of tamoxifen in stimulating the development and/ or growth of ovarian hemangioma is unknown. We may speculate that its prolonged, estrogenic effect on the ovary may be one of the stimulating factor.

Background Pituitary down regulators, aromatase inhibitors tamoxifen and chemotherapeutic drugs, all have a negative impact on bone health in breast cancer patients. Although trabecular bone accounts for only 20% of skeleton mass, bone resistance depends also on the its micro-architecture, or quality, of, in addition to bone density. The BESTEST® is an innovative and inexpensive diagnostic method that gives an indication of the quality of the bone structure: it measures the weight-bearing capacity of the bone structure, evaluated from simulated application of loads on bone structure images acquired by radiograms in the proximal epiphysis of the hand. Results are expressed as BSI_T-score and BSI_Z-score (which refers the results to the average value for the same age) and provide precious add-on information to densitometry. We discuss the preliminary results obtained in female patients undergoing breast cancer treatment. Material and methods 100 Caucasian women, took BESTEST® as follow-up while undergoing oncological treatment. Femoral neck DXA T-score available in a subgroup of 60. 10 patients self-reported an osteoporotic fracture, DXA T-score available for 8. Control population: 200 women, accessing BESTEST® and DXA for screening purposes, 30 self-reporting an osteoporotic fracture. Results Statistics: mean (min, max). NAgeBSI_T-scoreBSI_Z-scoreDXA_T-scorePopulation10061 (33, 88)-1.7 (-3.4, -0.0)-1.3 (-2.6, 0.6)NADXA subgroup (of oncological population)6062 (35, 88)-1.8 (-3.4, -0.1)-1.3 (-2.6, 0.6)-1.6 (-3.2, 0.5)Fractured subgroup1067 (56, 82)-2.4 (-2.9, -1.3)-1.8 (-2.6 -0.1)NAFractured subgroup with DXA868 (60, 82)-2.4 (-2.9, -1.3)-1.8 (-2.6 -0.1)-1.5 (-2.9, 0.1)Control20063 (32, 89)-1.1 (-3.6, 2.9)-0.6 (-3.0, 2.9)-1.9 (-3.7, 1.0) The fractured subgroup exhibits significantly lower BSI T-score than the population (T-test p< 0.0100) and results are similar after BSI Z-score correction for age (T-test p = 0.0300). The BSI T-score of the DXA subgroup is representative of the oncological population undergoing treatment (T-test p=0.8668). As expected, BSI T-score and DXA T-score are not correlated: R2 = 0.0917 in the control and R2 = 0.0294 in the population. The DXA subgroup exhibit significantly lower BSI T-score than the control (T-test p = 0.0002) and similar results are obtained after BSI Z-score correction for age. A lower significance (T-test p = 0.0281) is found for DXA T-score. The 8 fractured oncological patients exhibit significantly lower values of BSI T-score that the oncological population (T-test p = 0.038) and all patients have a BSI T-score indicative of a compromised trabecular structure. DXA T-score values cannot be considered statistically different (T-test p = 0.6744) and results span all possible diagnostic results from high risk to normal. Conclusions Statistical analyses show that bone micro-architecture is indeed affected by oncological treatment and that bone alterations due to oncological treatment are easily detected with BESTEST, especially when associated with fractures. This preliminary study clearly provides a rational background for further, deeper investigations into the use of a new, rapid and safe technique for monitoring the effect of breast and prostate cancers therapies on bone micro-architecture modifications. Citation Format: Cosmi F, Del Conte A, Foltran L, Nicolosi A, Saracchini S. New diagnostic tools for bone health assessment: Perspectives in medical oncology [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P1-03-08.