Ovarian hyperstimulation syndrome and complications of ART

Vloeberghs, Veerle; Peeraer, Karen; Pexsters, A.; D’Hooghe, Thomas

doi:10.1016/j.bpobgyn.2009.02.006

Cited by 88 publications

(74 citation statements)

References 105 publications

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“…These findings are in keeping with the incidence of OHSS (5-9%) that has been reported in the literature; and the severe form of the syndrome may occur in 1-3% [14].…”

Section: Discussionsupporting

confidence: 77%

Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles

Öçal

Şahmay

Çetin

et al. 2011

J Assist Reprod Genet

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Objective To evaluate predictive role of day-3 serum antiMüllerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles. Materials and methods Forty-one women with moderate/ severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E 2 , FSH, LH, AMH, inhibin-B levels measured on day 3 of the menstrual cycle before controlled ovarian hyperstimulation. Results Mean FSH was significantly lower (p<0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p=0.049, p<0.0001 and p<0.0001, respectively). There was no significant difference in inhibin B (p=0.112) and estradiol (p=0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC=0.87) and AFC (AUC=0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC=0.58) and LH (AUC= 0.61) had low accuracy. The cut-off value for AMH 3.3 ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV. Conclusion Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS.

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“…These findings are in keeping with the incidence of OHSS (5-9%) that has been reported in the literature; and the severe form of the syndrome may occur in 1-3% [14].…”

Section: Discussionsupporting

confidence: 77%

Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles

Öçal

Şahmay

Çetin

et al. 2011

J Assist Reprod Genet

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“…OHSS seems to result from an excessive secretion of vasoactive substances during ovarian stimulation (OS), namely vascular endothelial growth factor (VEFG) and factors that derive from the renin-angiotensin system [6]. This oversecretion of vasoactive substances is almost entirely dependent on the activity of luteinizing-hormone (LH).…”

Section: Introductionmentioning

confidence: 99%

Ovarian hyperstimulation syndrome after gonadotropin-releasing hormone agonist triggering and “freeze-all”: in-depth analysis of genetic predisposition

Santos‐Ribeiro

Polyzos

Stouffs

et al. 2015

J Assist Reprod Genet

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Purpose We report on the results of the whole-genome analysis performed in a patient who developed severe ovarian hyperstimulation syndrome (OHSS) following gonadotropinreleasing hormone (GnRH) agonist triggering in a Bfreeze-allp rotocol.Methods A 30-year-old patient with polycystic ovary syndrome who developed severe early-onset OHSS with clinical ascites, and slight renal and hepatic dysfunction was admitted for monitoring and treatment with cabergoline and intravenous albumin. Exome sequencing to assess for any known genetic predisposition for OHSS was performed.Results No known genetic variants associated with OHSS predisposition were found. Conclusions Case reports of severe OHSS following a Bfreeze-all^strategy are starting to arise, showing that OHSS has not been completely eliminated with this approach. Further studies should be conducted to confirm if such cases may be due to genetic predisposition or not.

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“…Pathological thrombosis in the setting of oral contraception [57], assisted reproductive technology [58], or postmenopausal hormone replacement [59] have been well documented. However, female gender has been found to bestow better outcomes after trauma, with associated superior post traumatic fibrinogen concentrations [60].…”

Section: Resultsmentioning

confidence: 99%

The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone

Swanepoel

Visagie

Lange

et al. 2016

Thrombosis Research

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Ovarian hyperstimulation syndrome and complications of ART

Cited by 88 publications

References 105 publications

Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles

Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles

Ovarian hyperstimulation syndrome after gonadotropin-releasing hormone agonist triggering and “freeze-all”: in-depth analysis of genetic predisposition

The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone

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