Ovarian Hyperstimulation Syndrome

Mahajan, Nalini

doi:10.5005/jp-journals-10016-1065

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…When couples must choose ART, at this stage, women are required to undergo hormonal stimulation that they should not experience. Hormonal stimulation is known to have very agonizing effects for a woman’s body, and it can even be life-threatening ( Mahajan, 2013 ). Because of the failure of male reproductive function, women must bear the consequences.…”

Section: Discussionmentioning

confidence: 99%

“Am I Masculine?” A metasynthesis of qualitative studies on traditional masculinity on infertility

Pakpahan

Ibrahim²,

William³

et al. 2023

F1000Res

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Background: The rate of infertility is increasing day by day. According to studies conducted worldwide, 30 million men are diagnosed with infertility. Cases of infertility are often associated with a failure to become male in society. Procreation and gender roles are often closely linked so that infertile men are often considered the second sex. Sometimes, this condition makes men question their masculinity. Methods: We performed a systematic review and metasynthesis with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline procedure on qualitative studies on ten databases exploring the experience of infertile men and their association with masculinity. Results: Twenty-four studies matched our question, and there are two major themes with eight subthemes that were obtained from the results of the metasynthesis of these studies. The impact of this gender issue is huge on men’s health and their social interactions. As a result, gender issues provide a space for debate and a burden on men. Sometimes, men develop mental health problems. The topic of masculinity and infertility is at odds with feminism and is susceptible to the societal stigma that results from the hegemonic conception of masculinity. Interestingly, the men must accept reality and follow the treatment process for infertility, although it affects their psychological well-being. Conclusions: These findings provide insight for physicians, as treating infertility requires a multidisciplinary team that does not only address procreation issues. Social issues related to gender roles often bring patients into harmful and dangerous conditions. To address the gender issue in men globally in several dimensions, however, a large study in various populations is still required.

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Section: Discussionmentioning

confidence: 99%

“Am I Masculine?” A metasynthesis of qualitative studies on traditional masculinity on infertility

Pakpahan

Ibrahim²,

William³

et al. 2023

F1000Res

View full text Add to dashboard Cite

show abstract

“…Our study showed a lower basic LH/FSH ratio at the beginning of the COH process in SOR patients compared with the control group (basic LH/FSH ratio in ultra-long/long protocol, LH/FSH ratio on COH day 2 in antagonist protocol, respectively). A small section of the population could be more sensitive to downregulation, exhibiting excessive pituitary suppression and insufficient LH levels ( 4 , 15 ). Usually, GnRH agonists inhibit 90% of the LH level but only inhibit about 40%–50% of the FSH level.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, receptor polymorphism inspection is not able to be widely used in clinic because it is time-consuming and money-consuming for most patients; of course, for patients with unexplained refractory SOR, FSH/LH receptor gene polymorphism inspection should be suggested to patients. Half-dose long-acting injection of GnRH-a or even 1/4~1/3 dosage can be considered to prevent excessive suppression of the pituitary gland for some patients with a history of SOR ( 1 , 4 ). When serum LH <1.0 IU/l, the startup time of Gn can be considered for postponement or that LH can be used at the startup time.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports mostly define high ovarian response as acquired ovum number >15 or estradiol (E2) peak >3,000 pg/ml ( 3 ), which mainly occurs in patients with PCOS, patients with low body weight or low BMI, or patients with a previous history of high ovarian response. High estrogen levels lead to increased vascular permeability and eventual extravasation of blood into the third body cavity ( 4 ). As a result, varying degrees of hydrothorax, ascites, and cerebral edema, as well as varying degrees of blood concentration, hypovolemic shock, and/or venous thrombosis, may occur with severe consequences.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Features and Management of Suboptimal Ovarian Response During in vitro Fertilization and Embryo Transfer: Analysis Based on a Retrospective Cohort Study

Yan

et al. 2022

Front. Endocrinol.

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BackgroundBased on dynamic changes of indicators during controlled ovarian hyperstimulation and of clinical outcomes of suboptimal ovarian response with different protocols, this study aimed to summarize the clinical characteristics of SOR and provide clinical recommendations.MethodsData of 125 patients with SOR and 125 controls who had undergone appropriate protocols for in vitro fertilization-embryo transfer were collected from a single medical center from January 2017 to January 2019. Basic clinical indexes, including age, BMI, antral-follicle count, infertility time, basic follicle-stimulating hormone, luteinizing hormone, LH/FSH ratio, estradiol, progesterone, testosterone, androstenedione, prolactin, anti-Mullerian hormone, and thyroid stimulating hormone levels, were analyzed using T-test. Dynamic indexes during COH, including amount and days of gonadotropin, sex hormone levels, and number of large/medium/small follicles at specified time periods, were analyzed using T-test and joint diagnosis analysis with ROC curves. Indexes of laboratory and clinical indicators were analyzed using the chi-square test.ResultsFor the SOR group, BMI, duration time, and dosage of gonadotropin used for SOR were significantly higher. In the ultra-long/long group, ROC curve analysis showed that the LH/FSH ratio and BMI yielded cutoff values of 0.61 and 21.35 kg/m2, respectively. A combined diagnosis of the two indexes showed higher sensitivity (90%) and specificity (59%). In the GnRH-ant group, ROC curve analysis showed an LH level, an LH/FSH ratio on COH day 2, and BMI yielded cutoff values of 2.47 IU/L, 0.57, and 23.95 kg/m2, respectively. Combining the two indexes with BMI, both showed increased sensitivity (77%) and specificity (72% and 74%). The estradiol level and progesterone level during the late follicular stage in SOR patients were significantly lower than those in control patients for both protocol groups. At each monitoring time, delayed follicular development was observed. The live-birth rate in fresh cycles of the ultra-long/long group and the live-birth rate in cumulative cycles of the antagonist group in the SOR group were lower than those in the control group.ConclusionSOR had adverse effects on clinical outcome. We provide some threshold values of basic LH/FSH ratio, BMI, COH day 2 LH, counts of follicles, and levels of estradiol/progesterone to be taken as reference to assist the early recognition of SOR.

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Association of IL-17 and IL-23 follicular fluid concentrations and gene expression profile in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome

et al. 2019

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Ovarian Hyperstimulation Syndrome

Abstract: ART is proven of great help to all the infertile couples anxious to get pregnant , but is not free of side effects and complications.

Cited by 4 publications

References 35 publications

“Am I Masculine?” A metasynthesis of qualitative studies on traditional masculinity on infertility

“Am I Masculine?” A metasynthesis of qualitative studies on traditional masculinity on infertility

Clinical Features and Management of Suboptimal Ovarian Response During in vitro Fertilization and Embryo Transfer: Analysis Based on a Retrospective Cohort Study

Association of IL-17 and IL-23 follicular fluid concentrations and gene expression profile in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome

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