Ovarian minimal residual disease in chronic myeloid leukaemia

Abir, Ronit; Aviram, A; Feinmesser, Meora; Stein, Jerry; Yaniv, Isaac; Parnes, Doris; Ben-Haroush, Avi; Meirow, Dror; Rabizadeh, Esther; Fisch, Benjamin

doi:10.1016/j.rbmo.2013.10.011

Cited by 35 publications

(23 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the data surrounding ovarian transplantation is controversial because typically only positive outcomes are reported, thus obscuring the success rate. Moreover, this technique has the underlying risk of reseeding cancerous cells in cases of blood borne malignancies and ovarian cancers [19,[31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

Laronda

Duncan

Hornick

et al. 2014

J Assist Reprod Genet

114

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

Laronda

Duncan

Hornick

et al. 2014

J Assist Reprod Genet

114

View full text Add to dashboard Cite

“…Ovarian tissue cryopreservation can be another option for these patients, as this method achieved over 130 clinical cases of live births (J. Donnez & Dolmans, ). However, preserved ovarian tissues may contain malignant cancer cells, and this approach has a risk of putting cancer cells back into patients (Dolmans, Luyckx, Donnez, Andersen, & Greve, ; Abir et al, ; Abir et al, ; Dolmans et al, ). A previous investigation reported that microscopic examination, polymerase chain reaction evaluation of altered DNA expression, and xenotransplantation studies of cryopreserved ovarian tissues are insufficient for detecting cancer cells and eliminating the risk (Bastings et al, ).…”

Section: Introductionmentioning

confidence: 99%

A new possibility in fertility preservation: The artificial ovary

Cho

Kim

Noh

et al. 2019

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Conventional fertility preservation methods such as oocyte or embryo cryopreservation are currently insufficient to treat including those patients with prepubertal cancer and premature ovarian failure. Ovarian tissue cryopreservation presents as an alternative but has limitations with a potential risk of reintroducing malignant cells in patients who recover from cancer, those of chemotherapy prior to tissue cryopreservation. The so called “artificial ovary” aims to resolve this issue by transplanting isolated follicles with or without a biological scaffold. The artificial ovary may also offer an effective alternative option for those who cannot benefit from traditional assisted reproductive techniques such as in vitro fertilisation. To date, in animal studies and human trial, the artificial ovary restored endocrine function, achieved in vivo follicular development, and resulted in successful pregnancies. However, development of a technique for higher follicular recovery rate and a more optimised design of delivery scaffold, better transplantation techniques to prevent postsurgical ischemia, and consideration for genetic safety are required for safer and consistent human clinical applications. Ideas from different transplantation surgeries (e.g., entire ovary, ovarian cortex, and transplantation with tissue‐engineered products) can be applied to enhance the efficacy of artificial ovarian transplantation. For the better application of artificial ovary, a deeper understanding of mechanical and biochemical properties of the ovary and folliculogenesis after cryopreservation, transplantation with or without scaffold, and development of sophisticated in vivo imaging techniques of transplanted artificial ovary need to precede its efficient clinical application.

show abstract

“…To date, autotransplantation of frozen/thawed ovarian cortical tissue has yielded about 130 live births worldwide [1]. Clinical application of this procedure is limited by the possible transmission of cancerous cells on the re-implantation of tissue from patients with blood-borne or highly metastatic malignancies [2][3][4]. The fact that the follicular basal lamina hinders cancerous cell invasion of ovarian follicles [5] has favored the development of two safer alternative strategies.…”

Section: Introductionmentioning

confidence: 99%

Do Bioreactor Designs with More Efficient Oxygen Supply to Ovarian Cortical Tissue Fragments Enhance Follicle Viability and Growth In Vitro?

et al. 2019

View full text Add to dashboard Cite

Background: Autotransplantation of cryopreserved ovarian tissue is currently the main option to preserve fertility for cancer patients. To avoid cancer cell reintroduction at transplantation, a multi-step culture system has been proposed to obtain fully competent oocytes for in vitro fertilization. Current in vitro systems are limited by the low number and health of secondary follicles produced during the first step culture of ovarian tissue fragments. To overcome such limitations, bioreactor designs have been proposed to enhance oxygen supply to the tissue, with inconsistent results. This retrospective study investigates, on theoretical grounds, whether the lack of a rational design of the proposed bioreactors prevented the full exploitation of follicle growth potential. Methods: Models describing oxygen transport in bioreactors and tissue were developed and used to predict oxygen availability inside ovarian tissue in the pertinent literature. Results: The proposed theoretical analysis suggests that a successful outcome is associated with enhanced oxygen availability in the cultured tissue in the considered bioreactor designs. This suggests that a rational approach to bioreactor design for ovarian tissue culture in vitro may help exploit tissue potential to support follicle growth.

show abstract

Ovarian minimal residual disease in chronic myeloid leukaemia

Cited by 35 publications

References 30 publications

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

A new possibility in fertility preservation: The artificial ovary

Do Bioreactor Designs with More Efficient Oxygen Supply to Ovarian Cortical Tissue Fragments Enhance Follicle Viability and Growth In Vitro?

Contact Info

Product

Resources

About