Ovarian reserve markers in women using various hormonal contraceptives

Landersoe, Selma Kloeve; Forman, Julie Lyng; Petersen, Kathrine Birch; Larsen, Elisabeth; Nøhr, Bugge; Hvidman, Helene Westring; Nielsen, Henriette Svarre; Andersen, Anders Nyboe

doi:10.1080/13625187.2019.1702158

Cited by 32 publications

(29 citation statements)

References 38 publications

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“…However, the extent of decline ranged from 14% to 55%, which could be explained by differences in type of HC use, duration of use, timing of AMH measurement during the menstrual cycle, and AMH assays used. Indeed, Landersoe et al ( 43 ) showed in a retrospective study that serum AMH levels were 30% to 40% lower in women using the oral contraceptive or the progesterone-only pill, while in women using an intrauterine device, only a decrease of 17% was observed. In addition, both studies reported a decline in AFC ( 42 , 43 ), strongly suggesting that the change in serum AMH levels caused by HC use results from a change in follicle dynamics rather than a direct effect on AMH gene regulation.…”

Section: Influencing Factors Of Serum Amhmentioning

confidence: 99%

“…Indeed, Landersoe et al ( 43 ) showed in a retrospective study that serum AMH levels were 30% to 40% lower in women using the oral contraceptive or the progesterone-only pill, while in women using an intrauterine device, only a decrease of 17% was observed. In addition, both studies reported a decline in AFC ( 42 , 43 ), strongly suggesting that the change in serum AMH levels caused by HC use results from a change in follicle dynamics rather than a direct effect on AMH gene regulation. However, a direct effect of an altered gonadotropin and sex steroid milieu on AMH expression cannot be ruled out.…”

Section: Influencing Factors Of Serum Amhmentioning

confidence: 99%

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Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Moolhuijsen

Visser

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

328

235

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Context Anti-Müllerian hormone is produced by granulosa cells of small growing follicles in the ovary. Serum AMH levels strongly correlate with the number of growing follicles, and therefore it has received increasing attention as a marker for ovarian reserve. This review summarizes recent findings and limitations in the application of serum AMH in ovarian reserve assessment. Evidence acquisition A PubMed search was conducted to find recent literature on the measurements and use of serum AMH as a marker for ovarian reserve. Evidence synthesis Serum AMH levels are measured to assess the ‘functional ovarian reserve’, a term that is preferred over ‘ovarian reserve’, since AMH levels reflect the pool of growing follicles which potentially can ovulate. Serum AMH levels are used in individualized FSH dosing protocols and may predict the risk of poor response or OHSS, but has limited value in predicting ongoing pregnancy. Serum AMH levels are studied to predict natural or disease-related age of menopause. Studies show that the age-dependent decline rates of AMH vary among women. The generalized implementation of serum AMH measurement has also lead to an increase in diagnostic assays, including automated assays. However, direct comparison of results remains problematic. Conclusion Serum AMH remains the preferred ovarian reserve marker. However, the lack of an international standard for AMH limits comparison between AMH assays. Furthermore, still little is known about endogenous and exogenous factors that influence serum AMH levels, which limits proper interpretation of AMH values in a clinical setting.

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Section: Influencing Factors Of Serum Amhmentioning

confidence: 99%

Section: Influencing Factors Of Serum Amhmentioning

confidence: 99%

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Moolhuijsen

Visser

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

328

235

View full text Add to dashboard Cite

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“…To our knowledge, however, there are no studies on the effects of hormonal contraceptive cycle (HC), i.e., active hormonal versus inactive Endocrines 2021, 2 80 phase, on EI in recreational athletes. As HC use continues its upward trend among female athletes [7], it is important to consider the effects of varying concentrations of exogenous sex hormones on EI.…”

Section: Introductionmentioning

confidence: 99%

Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Energy Intake and Metabolic Hormones—A Pilot Study

et al. 2021

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Sex hormones are suggested to influence energy intake (EI) and metabolic hormones. This study investigated the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on EI, energy availability (EA), and metabolic hormones in recreational athletes (eumenorrheic, NHC = 15 and monophasic HC-users, CHC = 9). In addition, 72-h dietary and training logs were collected in addition to blood samples, which were analyzed for 17β-estradiol (E2), progesterone (P4), leptin, total ghrelin, insulin, and tri-iodothyronine (T3). Measurements were completed at four time-points (phases): Bleeding, mid-follicular (FP)/active 1, ovulation (OVU)/active 2, mid-luteal (LP)/inactive in NHC/CHC, respectively. As expected, E2 and P4 fluctuated significantly in NHC (p < 0.05) and remained stable in CHC. In NHC, leptin increased significantly between bleeding and ovulation (p = 0.030) as well as between FP and OVU (p = 0.022). No group differences in other measured hormones were observed across the MC and HC cycle. The mean EI and EA were similar between phases, with no significant differences observed in macronutrient intake over either the MC or HC. While the MC phase might have a small, but statistically significant effect on leptin, the findings of the present study suggest that the MC or HC phase does not significantly alter ad libitum EI or EA in recreational athletes.

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“…At this point, however, it might be advisable to use a single assay in the clinic with precise thresholds to distinguish between patients expected to have a poor, normal, or high response to ovarian stimulation. Apart from this, factors potentially affecting AMH results should be considered, including oral contraceptives used for cycle synchronization before OS in GnRH antagonist regimens (17,77).…”

Section: Biomarkers' Considerationsmentioning

confidence: 99%

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Esteves¹,

Conforti

Sunkara

et al. 2021

Front. Endocrinol.

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The POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria were developed to help clinicians identify and classify low-prognosis patients undergoing assisted reproductive technology (ART) and provide guidance for possible therapeutic strategies to overcome infertility. Since its introduction, the number of published studies using the POSEIDON criteria has increased steadily. However, a critical analysis of existing evidence indicates inconsistent and incomplete reporting of critical outcomes. Therefore, we developed guidelines to help researchers improve the quality of reporting in studies applying the POSEIDON criteria. We also discuss the advantages of using the POSEIDON criteria in ART clinical studies and elaborate on possible study designs and critical endpoints. Our ultimate goal is to advance the knowledge concerning the clinical use of the POSEIDON criteria to patients, clinicians, and the infertility community.

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Ovarian reserve markers in women using various hormonal contraceptives

Cited by 32 publications

References 38 publications

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Energy Intake and Metabolic Hormones—A Pilot Study

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

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