Ovarian steroid secretion in normally menstruating women II. The contribution of the corpus luteum

Aedo, A.-R.; Pedersen, Philip J.; Pedersen, S. C.; Diczfalusy, E.

doi:10.1530/acta.0.0950222

Cited by 26 publications

(9 citation statements)

References 10 publications

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“…The results of the present study confirm two previous reports in which the concentration of oestradiol and progesterone fell to very low levels following surgical removal of the corpus luteum (Aedo, Pedersen, Pedersen & Diczfalusy, 1980;Nilsson et al, 1982). These results, together with the high concentration of these steroids in the CL (Swanston, McNatty & Baird, 1977) and in ovarian venous blood (Mikhail, 1970;Lloyd et al, 1971;Baird, 1977;Aedo et al, 1980), are conclusive proof that the CL is the major source of oestradiol and progesterone in the luteal phase of the human menstrual cycle.…”

Section: Discussionsupporting

confidence: 91%

“…These results, together with the high concentration of these steroids in the CL (Swanston, McNatty & Baird, 1977) and in ovarian venous blood (Mikhail, 1970;Lloyd et al, 1971;Baird, 1977;Aedo et al, 1980), are conclusive proof that the CL is the major source of oestradiol and progesterone in the luteal phase of the human menstrual cycle. The suppression of FSH and LH for 12-24 h after operation was probably due to the effect of general anaesthesia and post-operative sedation (Charters, Odell & Thompson, 1969;Carstensen, Amer, Wide & Amer, 1973;Yen, Vandenberg, Tsai & Parker, 1974).…”

Section: Discussionmentioning

confidence: 69%

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Effect of enucleation of the corpus luteum at different stages of the luteal phase of the human menstrual cycle on subsequent follicular development

Baird¹,

Bäckström²,

McNeilly³

et al. 1984

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Summary. To investigate the mechanism of suppression of follicular development during the luteal phase of the human menstrual cycle, the corpus luteum was enucleated surgically from 10 women at various times after ovulation. In the 24 h after CL enucleation there was an immediate and rapid fall in the concentration of oestradiol and progesterone and a temporary decline in the concentration of FSH and LH. Within 3 days, however, all 10 women showed evidence of renewed follicular activity as indicated by a progressive rise in the concentration of oestradiol. This rise was preceded by a rise in the concentration of FSH and LH, and ovulation, as indicated by a mid-cycle surge in LH and rise in the concentration of plasma progesterone, occurred 16\p=n-\19 days after enucleation. There was no significant difference in the time to ovulation following enucleation at different times of the luteal phase. The post \ x=req-\ operative follicular phase, measured from the time of enucleation, was 3 days longer than that observed pre-operatively from the first day of menstrual bleeding. In the follicular phase of post-operative cycles the concentration of FSH was higher and that of oestradiol lower than the corresponding values before surgery.These results indicate that the absence of healthy antral follicles in the luteal phase of the cycle is due to the inhibitory effects of the corpus luteum. The fact that, after CL enucleation, emergence of the dominant follicle was always preceded by a rise in the concentration of FSH and LH suggests that suppression of gonadotrophins by ovarian steroids secreted by the corpus luteum is responsible for the inhibition of follicular development during the luteal phase of the cycle.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 69%

Effect of enucleation of the corpus luteum at different stages of the luteal phase of the human menstrual cycle on subsequent follicular development

Baird¹,

Bäckström²,

McNeilly³

et al. 1984

Reproduction

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“…20-DHP is well known as a biologically active metabolite formed from progesterone in steroidogenic tissues (e.g. corpus luteum) as well as by peripheral 20a-reduction in liver, fat and other tissues (Zander et al 1958;Lin et al 1972;Aedo et al 1981). Using a continous infusion technique Lin et al (1972) estimated the peripheral conversion of progesterone into 20-DHP during the menstrual cycle as 10%.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of progesterone and some of its metabolites including deoxycorticosterone after oral and parenteral administration

Ottoson

Carlstrom

Damber

et al. 1984

BJOG

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Summary. Single 100‐mg doses of progesterone were given orally and as intramuscular injections t o four women during the follicular phase of the menstrual cycle. After oral administration serum levels of progesterone increased rapidly to reach luteal phase values (mean maximum level 55.6 nm) within 1–4 h and were still elevated after 12 h. The serum concentrations of 20α‐hydroxy‐4‐pregnen‐3‐one showed a similar pattern while there were only minor transient changes in 17α‐hydroxypro‐gesterone concentrations. The serum levels of cortisol and 4‐androstene‐3, 17‐dione were unaffected. In comparison, after intramuscular administration values two to three times higher than by the oral route were achieved. A significant increase in serum deoxycorticosterone was recorded in all women. The mean ratio between the change in deoxy‐corticosterone and progesterone was increased after oral administration. Oral treatment with natural progesterone may develop into a n attractive alternative to synthetic progestogens but the conversion of progesterone into a potent mineralocorticoid may be a potential disadvantage.

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“…The present paper deals with the assessment of the secretory activity of the largest follicle; a subse¬ quent paper will address itself to the study of the secretory function of the corpus luteum (Aedo et al 1980). …”

mentioning

confidence: 99%

Ovarian steroid secretion in normally menstruating women I. The contribution of the developing follicle

Aedo

Pedersen

et al. 1980

Acta Endocrinologica

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In 9 normally menstruating women undergoing surgical sterilization by tubal ligation the levels of a dozen steroids were measured in the blood from the peripheral and both ovarian veins before and after the enucleation of the largest follicle. In addition, the peripheral levels of progesterone, 17-hydroxyprogesterone, oestradiol and oestrone were measured during 3 pre\x=req-\ operative and 3 post-operative days. Compared to their levels in peripheral blood, the levels of pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, androstenedione, testosterone and oestradiol were significantly higher in the blood draining both ovaries, while those of oestrone were higher only in the blood draining the 'active' ovary (containing the largest follicle) and those of dehydroepiandrosterone and cortisol only in the blood draining the contralateral 'inactive' ovary. No differences were found as far as the levels of 20\g=a\-dihydroprogesterone and dihydrotestosterone are concerned. Furthermore, a comparison of the steroid levels in the blood draining the two ovaries revealed that the levels of oestradiol and oestrone were higher in the venous blood draining the 'active' ovary and those of dehydroepiandrosterone in the blood draining the 'inactive' one. Enucleation of the largest follicle resulted in the following changes: 1) A significant drop in the peripheral oestradiol levels which was associated with a significant rise in the levels of the other steroids studied, except those of androstenedione, testosterone and oestrone, which remained unchanged. 2) Decreased levels of oestradiol and oestrone and increased levels of dihydrotestosterone and cortisol in the venous blood draining the ovary that previously contained the largest follicle. 3) No differences were any longer found in steroid levels between the blood draining the two ovaries, with the exception of cortisol levels, which were higher in the blood originating from the 'inactive' ovary. 4) The levels of 17-hydroxyprogesterone, androstenedione, testosterone, oestradiol and oestrone were higher in the blood draining both ovaries when compared to their peripheral levels. 5) The peripheral levels of 17-hydroxyprogesterone, oestradiol and oestrone dropped to early follicular phase values within 24 h and remained at that level for at least 3 days. The results are interpreted as indicating that the principal secretory products of the largest follicle in vivo are oestradiol and oestrone. Moreover, both ovaries secrete 17-hydroxyprogesterone, androstenedione and testosterone and additional amounts of oestradiol, and most probably also some pregnenolone, 17-hydroxypregnenolone and progesterone. The relative contribution to the peripheral levels of 17-hydroxyprogesterone by the largest follicle as compared to that of other ovarian structures requires further investigation. It is emphasized that the stress associated with surgery gradually increases the secretion of a number of adrenal steroids, that may reach the ovaries in considerable quantities. This may ...

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Ovarian steroid secretion in normally menstruating women II. The contribution of the corpus luteum

Cited by 26 publications

References 10 publications

Effect of enucleation of the corpus luteum at different stages of the luteal phase of the human menstrual cycle on subsequent follicular development

Effect of enucleation of the corpus luteum at different stages of the luteal phase of the human menstrual cycle on subsequent follicular development

Serum levels of progesterone and some of its metabolites including deoxycorticosterone after oral and parenteral administration

Ovarian steroid secretion in normally menstruating women I. The contribution of the developing follicle

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