Ovarian Stimulators, Intrauterine Insemination, and Assisted Reproductive Technologies Use and the Risk of Major Congenital Malformations—The AtRISK Study

Chaabane, Sonia; Sheehy, Odile; Monnier, Patricia; Bissonnette, François; Trasler, Jacquetta M.; Fraser, William D.; Bérard, Anick

doi:10.1002/bdrb.21178

Cited by 9 publications

(7 citation statements)

References 65 publications

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“…These studies have also revealed an increased risk of intellectual disability and autism (Sandin, Nygren, Iliadou, Hultman, & Reichenberg, ). ART has been moreover linked to an increased risk of fetal growth restriction, low birth weight (Bloise, Feuer, & Rinaudo, ), congenital anomalies (Chaabane et al, ), premature birth and other perinatal complications (Pinborg et al, ) that could have consequences after birth. Several imprinting disorders have also been associated with ART, including the syndromes Angelman, Silver‐Russell, and Beckwith‐Wiedemann (Odom & Segars, ; Õunap, ).…”

Section: Long‐term and Transgenerational Effects Of Artmentioning

confidence: 99%

Embryo responses to stress induced by assisted reproductive technologies

Ramos‐Ibeas

Heras

Gómez-Redondo

et al. 2019

Molecular Reproduction Devel

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Assisted reproductive technology (ART) has led to the birth of millions of babies. In cattle, thousands of embryos are produced annually. However, since the introduction and widespread use of ART, negative effects on embryos and offspring are starting to emerge. Knowledge so far, mostly provided by animal models, indicates that suboptimal conditions during ART can affect embryo viability and quality, and may induce embryonic stress responses. These stress responses take the form of severe gene expression alterations or modifications in critical epigenetic marks established during early developmental stages that can persist after birth. Unfortunately, while developmental plasticity allows the embryo to survive these stressful conditions, such insult may lead to adult health problems and to long-term effects on offspring that could be transmitted to subsequent generations. In this review, we describe how in mice, livestock, and humans, besides affecting the development of the embryo itself, ART stressors may also have significant repercussions on offspring health and physiology. Finally, we argue the case that better control of stressors during ART will help improve embryo quality and offspring health. K E Y W O R D S assisted reproductive technologies, bovine, embryo, human, mouse, stress

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Section: Long‐term and Transgenerational Effects Of Artmentioning

confidence: 99%

Embryo responses to stress induced by assisted reproductive technologies

Ramos‐Ibeas

Heras

Gómez-Redondo

et al. 2019

Molecular Reproduction Devel

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“…10 Evidence-based findings showed that children conceived with ART were at an increased risk of major congenital malformations and low birth weight compared with children who had been spontaneously conceived. [11][12][13][14][15][16][17] However, most studies failed to observe this association within groups exposed to specific assisted methods and specifically among singletons. Studies focused on in vitro fertilization or inseminations or combined non-in vitro methods together, which has limited clinical implications.…”

mentioning

confidence: 99%

Medically assisted reproduction and the risk of preterm birth: a case–control study using data from the Quebec Pregnancy Cohort

Gorgui

Sheehy

Trasler

et al. 2020

cmajo

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Background: The use of fertility treatments has been growing over the past decade, but these treatments are not without risk. We aimed to quantify the risk of preterm birth associated with the use of ovarian stimulators (OS) and assisted reproductive technologies (ART) overall and by type of fertility treatment. Methods:We conducted a case-control analysis of data from the Quebec Pregnancy Cohort. We included singleton pregnancies ending in a live birth during the time when Quebec operated a universal reimbursement program for assisted reproduction (2010)(2011)(2012)(2013)(2014)(2015). Fertility treatments were defined dichotomously, and pregnancies resulting from spontaneous conception were used as the reference. We categorized fertility treatments into subgroups: ovarian stimulators alone, ART alone and OS and ART combined. Preterm birth was defined as birth before 37 weeks' gestation. We estimated odds ratios (ORs) for the association between type of assisted reproduction and preterm birth using generalized estimating equation models and adjusted ORs for potential confounders.Results: A total of 57 624 pregnancies were included in the study. During the study period, 2055 pregnancies were conceived through the use of OS, ART or both: 419 involved OS alone, 150 involved ART alone and 1486 involved both OS and ART. When we adjusted for potential confounders, conception with OS, ART or both was associated with an increased risk of preterm birth (adjusted OR 1.46, 95% confidence interval [CI] 1.25-1.72, 182 exposed cases). All types of assisted reproduction were associated with an increased risk of preterm birth compared with pregnancies conceived spontaneously

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“…Malformations were classified according to the ICD-10 classification using Q-codes (Q00-Q99). Minor malformations (Q 10, Q16.2, Q17.0-17.9, Q18.0-18.2, Q18.4-18.9, Q25.0, Q27.0, Q38.1, Q51.5, Q51.6, Q52.0-Q52.7, Q53.0-Q53.9, Q66.3-Q66.6, Q69.0-Q69.9, Q70.0-Q70.9, Q81.0-Q81.9, Q82.1-Q82.9, Q83.0-Q83.9, Q84.0-Q84.9, Q85.0, Q86.0, Q95.0-Q95.2, Q95.4-Q95.5, Q95.9) were not included in the congenital malformation group [41].…”

Section: Data Collectionmentioning

confidence: 99%

Impact of high magnification sperm selection on neonatal outcomes: a retrospective study

Gaspard

Vanderzwalmen

Wirleitner

et al. 2018

J Assist Reprod Genet

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In the present study, the malformation rates observed in the IMSI and ICSI groups were not significantly different, even if slightly lower after IMSI. However, the observed difference followed the same trends observed in previous reports, indicating the possible impact of IMSI on decreasing congenital malformation occurrences. This highlights the necessity to prospectively evaluate the impact of IMSI on neonatal outcome after IVF treatment.

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Ovarian Stimulators, Intrauterine Insemination, and Assisted Reproductive Technologies Use and the Risk of Major Congenital Malformations—The AtRISK Study

Cited by 9 publications

References 65 publications

Embryo responses to stress induced by assisted reproductive technologies

Embryo responses to stress induced by assisted reproductive technologies

Medically assisted reproduction and the risk of preterm birth: a case–control study using data from the Quebec Pregnancy Cohort

Impact of high magnification sperm selection on neonatal outcomes: a retrospective study

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