2016
DOI: 10.1038/srep35299
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Ovarian transcriptomic study reveals the differential regulation of miRNAs and lncRNAs related to fecundity in different sheep

Abstract: miRNAs and lncRNAs, which represent one of the most highly expressed classes of ncRNAs in development, are attracting increasing interest. A variety of regulators is considered to be implicated in sheep species with different fecundity. However, interactions between miRNAs and lncRNAs and changes in the expression of regulatory lncRNAs in sheep fecundity have not yet been reported. To characterize the important roles of miRNAs and lncRNAs and elucidate their regulating networks in sheep prolificacy, a genome-w… Show more

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Cited by 65 publications
(60 citation statements)
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“…With the presentation of the hypothesis of competing endogenous RNA (ceRNA), our previous findings suggest that lncRNAs could be regulated by miRNAs and thereby favour the expression of repressed mRNA targets. For example, chrx_30776_star and MYH15 interact with each other, indicating that MYH15 may combine with chrx_30776_star through competition with other target mRNAs34.…”
Section: Discussionmentioning
confidence: 99%
“…With the presentation of the hypothesis of competing endogenous RNA (ceRNA), our previous findings suggest that lncRNAs could be regulated by miRNAs and thereby favour the expression of repressed mRNA targets. For example, chrx_30776_star and MYH15 interact with each other, indicating that MYH15 may combine with chrx_30776_star through competition with other target mRNAs34.…”
Section: Discussionmentioning
confidence: 99%
“…With the rapid development of next generation sequencing (NGS), the study of miRNA becomes more attainable than before891011. Fat deposition is a complex biological process where miRNAs may play a regulatory role.…”
mentioning
confidence: 99%
“…The sequence reads from these analyses are individually mapped to the source genome and counted to obtain the number and density of reads corresponding to the RNA from each known exon, splice event or new candidate gene15. This technique has been successfully applied in multiple organisms for the genome-wide analysis of RNAs, such as yeast16, sheep1718192021, and human22. The current study aimed to characterize distinct gene regulation between two domestic goats raised in China using genome-wide miRNA profiling via high-throughput deep RNA sequencing (RNA-Seq) technology.…”
mentioning
confidence: 99%