Ovarian volume, age, and menopausal status

Giacobbe, Marcelo; Pinto‐Neto, Aarão Mendes; Martinez, Edson Zangiacomi

doi:10.1097/01.gme.0000082296.62794.f2

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…The study demonstrated a stable ovarian volume to age 35 yr, the greatest decline between 35 and 55 yr, and a very minor decline after age 55 yr (7). Similar to follicle number, other studies demonstrate a linear (8,40), biphasic (41), or quadratic decline (38). The current study demonstrates a linear decline in ovarian volume in controls and in women with PCOS for the first time, but a higher initial volume, a lesser slope, and a greater decrement in the volume change from premenopause to postmenopause in women with PCOS.…”

Section: Discussionmentioning

confidence: 53%

Criteria for Polycystic Ovarian Morphology in Polycystic Ovary Syndrome as a Function of Age

Alsamarai

Adams

Murphy

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

100

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Section: Discussionmentioning

confidence: 53%

Criteria for Polycystic Ovarian Morphology in Polycystic Ovary Syndrome as a Function of Age

Alsamarai

Adams

Murphy

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

100

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“…58 Structural changes in the aged human ovary have been noted to occur after menopause, and the health and quality of human oocytes are cited to progressively decline with age. 18,31,34,51,58,70 …”

Section: Discussionmentioning

confidence: 99%

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

et al. 2016

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Chimpanzees (Pan troglodytes) have served as an important model for studies of reproductive diseases and aging-related disorders in humans. However, limited information is available about spontaneously occurring reproductive tract lesions in aging chimpanzees. In this article, the authors present histopathologic descriptions of lesions identified in the reproductive tract, including the mammary gland, of 33 female and 34 male aged chimpanzees from 3 captive populations. The most common findings in female chimpanzees were ovarian atrophy, uterine leiomyoma, adenomyosis, and endometrial atrophy. The most common findings in male chimpanzees were seminiferous tubule degeneration and lymphocytic infiltrates in the prostate gland. Other less common lesions included an ovarian granulosa cell tumor, cystic endometrial hyperplasia, an endometrial polyp, uterine artery hypertrophy and mineralization, atrophic vaginitis, mammary gland inflammation, prostatic epithelial hyperplasia, dilated seminal vesicles, a sperm granuloma, and lymphocytic infiltrates in the epididymis. The findings in this study closely mimic changes described in the reproductive tract of aged humans, with the exception of a lack of malignant changes observed in the mammary gland and prostate gland.

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“…For example, in an early study of hormonal changes across the human life span, Sherman and Korenman [5] reported that, as females age, intermenstrual intervals increase, a phenomenon thought to result directly from lower serum estradiol (E 2 ) levels and elevated follicle-stimulating hormone (FSH) concentrations. In addition to endocrine changes, the senescent ovary shrinks in size [6, 7], undergoes vascular changes [8, 9], decreases the rate of folliculogenesis [10], reorganizes morphologically [6], and increases androgen output [11-13]. These alterations in reproductive parameters have been linked to other markers of aging, including diminished bone density [14-16], cognition [17-21], and cardiovascular health [22, 23].…”

Section: Introductionmentioning

confidence: 99%

Menopause in Nonhuman Primates?1

Walker

Herndon

2008

Biology of Reproduction

160

133

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A gradual alteration in the mechanisms underlying reproduction and fertility characterizes the aging process in human females. These changes culminate in menopause, conventionally defined as a cessation of menstrual cycles that marks the end of reproductive capacity. In fact, a central and defining event in menopause is the discontinuation of ovulation, which is correlated with a number of structural and functional changes in the reproductive axis. Despite several decades of research, a degree of uncertainty remains as to whether nonhuman primates undergo menopause, and whether they are suitable models of human reproductive senescence. We review some of the controversies that have clouded our understanding of reproductive aging in nonhuman primates, including issues of definition, timing, comparability of data from wild versus captive populations, and cross-species comparisons. The existing data support the view that menopause occurs in a number of primate species, and is not unique to humans.

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Ovarian volume, age, and menopausal status

Abstract: Ovarian volume differs according to age in premenopausal and postmenopausal women. Menopausal status is more important than age in determining ovarian volume. The data suggest that ovarian volume and age are quite accurate in predicting menopausal status.

Cited by 11 publications

References 13 publications

Criteria for Polycystic Ovarian Morphology in Polycystic Ovary Syndrome as a Function of Age

Criteria for Polycystic Ovarian Morphology in Polycystic Ovary Syndrome as a Function of Age

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

Menopause in Nonhuman Primates?1

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