Ovariectomy enhances female rats' susceptibility to metabolic, oxidative, and heat shock response effects induced by a high-fat diet and fine particulate matter

Costa-Beber, Lílian Corrêa; Goettems-Fiorin, Pauline Brendler; Santos, Jaíne Borges Dos; Friske, Paula Taís; Frizzo, Matias Nunes; Heck, Thiago Gomes; Hirsch, Gabriela Elisa; Ludwig, Mirna Stela

doi:10.1016/j.exger.2020.111215

Cited by 15 publications

(5 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although estrogens are known to enhance autoimmune diseases [81], decreased estrogen increases susceptibility to infectious diseases, as demonstrated by the defective innate immune responses against viral infection in OVX mice [82]. In addition, OVX enhanced the susceptibility of female rats to dyslipidemia with a decrease in innate cytokines, suggesting impaired metabolic and immune homeostatic responses with the loss of estrogens [83].…”

Section: Alterations In Fatty Acid Metabolismmentioning

confidence: 99%

Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women

Jung

2021

Nutrients

121

View full text Add to dashboard Cite

Aging women experience hormonal changes, such as decreased estrogen and increased circulating androgen, due to natural or surgical menopause. These hormonal changes make postmenopausal women vulnerable to body composition changes, muscle loss, and abdominal obesity; with a sedentary lifestyle, these changes affect overall energy expenditure and basal metabolic rate. In addition, fat redistribution due to hormonal changes leads to changes in body shape. In particular, increased bone marrow-derived adipocytes due to estrogen loss contribute to increased visceral fat in postmenopausal women. Enhanced visceral fat lipolysis by adipose tissue lipoprotein lipase triggers the production of excessive free fatty acids, causing insulin resistance and metabolic diseases. Because genes involved in β-oxidation are downregulated by estradiol loss, excess free fatty acids produced by lipolysis of visceral fat cannot be used appropriately as an energy source through β-oxidation. Moreover, aged women show increased adipogenesis due to upregulated expression of genes related to fat accumulation. As a result, the catabolism of ATP production associated with β-oxidation decreases, and metabolism associated with lipid synthesis increases. This review describes the changes in energy metabolism and lipid metabolic abnormalities that are the background of weight gain in postmenopausal women.

show abstract

Section: Alterations In Fatty Acid Metabolismmentioning

confidence: 99%

Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women

Jung

2021

Nutrients

121

View full text Add to dashboard Cite

show abstract

“…The upregulation of superoxide anions and markers such as superoxide dismutase (SOD), nuclear factor erythroid 2-related factor (Nrf)-2, and heat shock 70 kDa protein-1 (HSP72) provides supporting evidence for increased ROS in WAT and BAT of PM 2.5 -exposed animals [ 23 , 55 ]. Chiefly, HSP72 represents a hallmark of functional derangement under PM exposure, since its expression correlates with inflammation and insulin resistance [ 56 , 57 ]. ROS act as co-factors in the induction of mitochondria and endoplasmic reticulum (ER) functional impairment [ 58 ].…”

Section: Pm 25 Exposure Increases Oxidative Stress...mentioning

confidence: 99%

White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure

Guardia¹,

Shin

2022

J Mol Med

View full text Add to dashboard Cite

Chronic exposure to high levels of particulate matter (PM) is correlated to a higher prevalence of cardio-metabolic disturbances. Adipose tissue represents a pivotal regulator of metabolic homeostasis, and its dysfunction is associated with health issues in PM-exposed models. This review discusses the adaptive changes of white (WAT) and brown (BAT) adipose tissue in response to fine particulate matter (PM2.5), investigating the underlying pathophysiology. In exposed models, PM2.5 increases oxidative stress and impairs mitochondria functionality and biogenesis in WAT and BAT. Chronic exposure also upregulates the main apoptotic/pro-inflammatory pathways and promotes the infiltration of monocytes and the accumulation of activated macrophages. Oxidative stress and inflammation are responsible for the inhibition of insulin signal transduction and glucose uptake in both the adipose tissues. The increased inflammatory status also suppresses the metabolic activity of brown adipocytes, promoting the whitening. Altogether, this evidence suggests the shift of WAT and BAT toward an inflammatory and metabolic dysfunctional phenotype. Although the underlying mechanisms remain to be clarified, the development of inflammation in lungs, gut, and hypothalamus seems to have a pivotal role in the alteration of adipose tissue homeostasis. The potential consequences on systemic cardio-metabolic health render the relationship PM-adipose tissue a key issue to investigate. Graphical abstract

show abstract

“…Recent studies also support the hypothesis that increasing age 25,31 and female gender 32,33 are risk factors for AF-related stroke. The frailty and higher prevalence of chronic cardiopulmonary diseases in older adults 34 and worsening oxidative stress in females 35 are possible reasons why older female patients have a higher risk of AF due to the effects of PM2.5. These results demand more protection for older and female patients with AF against PM2.5 exposure.…”

Section: Discussionmentioning

confidence: 99%

Short-term effect of PM2.5 on stroke in susceptible populations: A case-crossover study

Wang

Han

Wang

et al. 2022

International Journal of Stroke

View full text Add to dashboard Cite

BACKGROUND: Fine particulate matter (PM2.5) is a risk factor for stroke, and patients with pre-existing diseases appear to be particularly susceptible. We conducted a case-crossover study to examine the association between short-term exposure to fine particulate matter (PM2.5) and hospital admission for stroke in individuals with atrial fibrillation (AF), hypertension, diabetes, or hyperlipidemia. METHODS: Patients diagnosed with acute ischemic stroke (AIS) were recruited from 2015 to 2017 in Chinese Stroke Center Alliances. We estimated daily PM2.5 average exposures with a spatial resolution of 0.1° using a data assimilation approach combining satellite measurements, air model simulations, and monitoring values. Conditional logistic regression was used to assess PM2.5-related stroke risk in patients with pre-existing medical co-morbidities. RESULTS: A total of 155 616 patients diagnosed with AIS were admitted. Patients with a history of AF (n=15 430), hypertension (n=138 220), diabetes (n=43 737), or hyperlipidemia (n=16 855) were assessed separately. A 10 µg/m3 increase in daily PM2.5 was associated with a significant increase in AIS for individuals with AF at lag 4 (OR, 1.008; 95% CI, 1.002-1.014), and with hypertension (OR, 1.008; 95% CI, 1.006-1.010), diabetes (OR, 1.006; 95% CI, 1.003-1.010), and hyperlipidemia (OR, 1.007; 95% CI, 1.001-1.012) at lag 0-7. Elderly (≥65 years old) and female patients with AF had significantly higher associations at lag 5 (OR, 1.009; 95% CI, 1.002-1.015) and lag 5 (OR, 1.010; 95% CI, 1.002-1.018), respectively. CONCLUSIONS: Short-term exposure to PM2.5 is significantly associated with hospital admission for stroke in individuals with pre-existing medical histories, especially in older or female patients with AF. Preventative measures to reduce PM2.5 concentrations are particularly important in individuals with other medical co-morbidities.

show abstract

Ovariectomy enhances female rats' susceptibility to metabolic, oxidative, and heat shock response effects induced by a high-fat diet and fine particulate matter

Cited by 15 publications

References 83 publications

Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women

Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women

White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure

Short-term effect of PM2.5 on stroke in susceptible populations: A case-crossover study

Contact Info

Product

Resources

About