Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women

Ko, Seong-Hee; Jung, YunJae

doi:10.3390/nu13124556

Cited by 120 publications

(81 citation statements)

References 84 publications

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“…Also, sarcopenia and increased fat mass can modify the energy metabolic rate and consequently basal metabolic rate (BMR) in postmenopausal women [ 9 ]. Several data point that a decrease in skeletal muscle reflected by the loss of LBM in patients with sarcopenia and an increase in adipose tissue cause a lower BMR [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The lower basal metabolic rate is associated with increased risk of osteosarcopenia in postmenopausal women

et al. 2022

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Background The goal of this study is to clarify clinical, functional, and biochemical features of postmenopausal women who are at risk of developing osteosarcopenia. Methods This is a cross-sectional study undertaken to investigate the co-accordance of osteoporosis and sarcopenia and common risk factors on 305 postmenopausal Iranian women. Sarcopenia and osteoporosis were defined based on the European Working Group on sarcopenia in Older People guidelines and WHO criteria, respectively. Confounding factors including age, menopausal age, obesity, sun exposure, physical activity, macronutrient composition, and calcium and vitamin D supplementations were considered for all participants. A multivariate model was used to consider the common risk factors of both disorders; osteoporosis and sarcopenia. Results The mean age was 57.9 years ± 6.0 SD (range: 48–78 years) and 37.4% of patients were 60 years or older. Among all participants, 35.7% were obese (BMI ≥ 30 kg/m2). Approximately 45% of all the study population had insufficient physical activity and at least half of participants had insufficient intake of protein. There was a significant correlation between bone density and muscle mass and basal metabolic rate (BMR) (p < 0.01). In multivariate-multivariable regression model, after Bonferroni correction for obesity, lower BMR was the only one associated with both lower muscle mass and bone density in lumbar and hip sites (p < 0.007). Conclusions Our data suggest that low BMR might be an early predictor for concordance of osteoporosis and sarcopenia in postmenopausal women.

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Section: Introductionmentioning

confidence: 99%

The lower basal metabolic rate is associated with increased risk of osteosarcopenia in postmenopausal women

et al. 2022

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“…Although the average age range of patients included in this study was 30-40 years old, the influence of age factors on lipid composition is partly excluded. In particular, menopause is likely to affect lipid metabolism (85,86) and there were 9 cases over 45 years old in this study, the effect of menopause on plasma lipidomics needs to be further considered. On the other hand, other signatures that can discriminate unipolar from bipolar depression including gut microbiota, imaging features and metabolomics were reported recently (87)(88)(89), the advantages, disadvantages and interaction between lipidomic characteristics and those signatures still need to be further explored.…”

Section: Discussionmentioning

confidence: 96%

Alterations of Plasma Lipids in Adult Women With Major Depressive Disorder and Bipolar Depression

Zhang¹,

Guo²,

Li³

et al. 2022

Front. Psychiatry

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Lipidomics has been established as a potential tool for the investigation of mental diseases. However, the composition analysis and the comparison of the peripheral lipids regarding adult women with major depressive depression (MDD) or bipolar depression (BPD) has been poorly addressed. In the present study, age-matched female individuals with MDD (n = 28), BPD (n = 22) and healthy controls (HC, n = 25) were enrolled. Clinical symptoms were assessed and the plasma samples were analyzed by comprehensive lipid profiling based on liquid chromatography-mass spectrometry (LC/MS). We found that the composition of lipids was remarkably changed in the patients with MDD and BPD when compared to HC or compared to each other. Moreover, we identified diagnostic potential biomarkers comprising 20 lipids that can distinguish MDD from HC (area under the curve, AUC = 0.897) and 8 lipids that can distinguish BPD from HC (AUC = 0.784), as well as 13 lipids were identified to distinguish MDD from BPD with moderate reliability (AUC = 0.860). This study provides further understanding of abnormal lipid metabolism in adult women with MDD and BPD and may develop lipid classifiers able to effectively discriminate MDD from BPD and HC.

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“…At present, the shared pathogenic mechanisms or even cross-talk effect between bone metabolism and lipometabolism may also exist ( 17 ). An important role in the regulation of lipid metabolism is attributed to the estrogen secretion in postmenopausal women ( 18 , 19 ). Menopausal women are more likely to form fat accumulation, with an increase of total cholesterol, triglyceride, LDL-C, and decrease in HDL-C ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Elucidating the relationship between dyslipidemia and osteoporosis: A multicenter, prospective cohort study protocol

Wei

Zhang

Sun

et al. 2022

Front. Cardiovasc. Med.

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BackgroundA previous study has shown similar factors in dyslipidemias (DL) and osteoporosis (OP). However, no cohort study has been reported on the association between DL and OP in the postmenopausal population in China. This study aims to provide epidemiological and pathophysiological evidence regarding the association between DL and bone mass and fracture risk.MethodsThis is a multicenter, prospective cohort study that will have approximately 1,100 representative participants enrolled from multiple hospitals or communities in China. They will be divided into two groups according to whether or not they are exposed to dyslipidemia and will be epidemiologically investigated. Each participant will be visited continuously once every year with a minimum follow-up of 3 years to track incidences of OP. Meanwhile, free bone density screening, questionnaires, and blood sample collection will also be completed during this period.ConclusionThe current study is likely to provide greater insight into the relationship between lipid metabolism and bone metabolism in postmenopausal women. Furthermore, the research result maybe fed into public health strategies with regard to metabolic disease prevention.

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Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women

Cited by 120 publications

References 84 publications

The lower basal metabolic rate is associated with increased risk of osteosarcopenia in postmenopausal women

The lower basal metabolic rate is associated with increased risk of osteosarcopenia in postmenopausal women

Alterations of Plasma Lipids in Adult Women With Major Depressive Disorder and Bipolar Depression

Elucidating the relationship between dyslipidemia and osteoporosis: A multicenter, prospective cohort study protocol

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