Overall Monotropic Behavior of a Metastable Phase of Biclotymol, 2,2′-Methylenebis(4-Chloro-3-Methyl-Isopropylphenol), Inferred From Experimental and Topological Construction of the Related P-T State Diagram

Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide

“…13 In this case, form II does not possess a stable phase region in the phase diagram, because it will always be metastable against form I, the liquid, and the vapor phase. Other examples of monotropic APIs are biclotymol, 14 rimonabant, 15 triethylenetetramine hydrochloride 16,17 and rotigotine. 18 One could argue that this case of polymorphism was resolved because of the availability of vapor pressure data.…”

“…As mentioned above, the APIs biclotymol, rotigotine, rimonabant, and triethylenetetramine hydrochloride were recently found to be overall monotropic dimorphic systems. [14][15][16]18 In addition, the organic molecules 2,2-dichloropropane and tetrachloromethane were found to exhibit overall monotropy. 24,25 Figure Captions Tables Captions Table 1.…”

Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic

“…As visible in Figure 5(a), the metastable Phase II grows into needle-like crystallites, i.e., it displays a typically onedimensional growth. Such long and thin crystallites appear to nucleate at different times after the induction time t o (they display different length at different elapsed times) and to grow forming bundles (Schammé et al, 2015;Céolin et al, 2008). The exponent n = 2 corresponds then to onedimensional (needle-like) crystallization with a continuous, time-independent nucleation rate after the onset time t o (Çelikbilek et al, 2012).…”

“…The sample batch was the same as in our previous work (Céolin et al, 2008). Differential scanning calorimetry measurements were carried out in the temperature range between 250 and 450 K with heating or cooling rates 10 K min…”

Relationship between the two-component system 1-Br-adamantane + 1-Cl-adamantane and the high-pressure properties of the pure components

“…2(b)]. To find out such stability relationships between the solid phases, the topological temperature-pressure (P-T) phase diagram must be calculated [44][45][46][47][48][49][50]. A topological P-T phase diagram accounts for the phase relationships between all the polymorphs and the vapor and liquid phases and it is a consequence of the basis of thermodynamics established by Gibbs.…”