Overall Survival (Os) And Quality-Of-Life (Qol) Outcomes In Recurrent Or Metastatic Squamous Cell Carcinoma Of The Head And Neck (Scchn): A Systematic Literature Review

Abstract

A433Objectives: Obesity is associated with an increased risk of breast cancer, and is also positively associated with tumor size and a higher probability of having positive axillary lymph nodes and faster growing tumors. It has been suggested that up to 50 % of postmenopausal breast cancers are attributable to obesity. Accordingly, this study assessed the impact of lifestyle intervention on body mass index (BMI) in women with breast cancer. MethOds: This is a randomized clinical trial study .The Study samples were 80 women with stage I, II, or III breast cancer, that operated for breast cancer and their chemotherapy or radiation therapy completed 3-18 months ago. They are divided randomly into two groups; control group and lifestyle interventions group. Those in the lifestyle intervention group were instructed to practice aerobic exercises 45-60 minutes three times per week for 24 weeks with dietary energy restriction training. Those in the control group were instructed to continue normal activities and their routine health care. Data were obtained from the patient information form and body mass index form that completed before and after the lifestyle intervention in both groups. Results: No baseline differences existed between the two groups for the mean of BMI (p = 0.366) before the study ; but the mean of BMI in the lifestyle intervention group after the intervention decreased to 25.12 ± 2.86, while in the control group it increased to 30.42 ± 6.89. The difference between the mean of BMI among the two groups after the intervention was statistically high (p = < 0.001). cOnclusiOns: Lifestyle intervention could be considered as part of a cancer survivorship program. For women with breast cancer, lifestyle intervention can decrease body mass index. Additional research in lifestyle intervention along with cognitive behavioral therapy also may be beneficial.

Polo‑like kinase�4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma

“…It is well-known that patients with GBM have a considerably poor prognosis, even following maximal treatment (3). To identify the molecular mechanism for GBM tumor recurrence and treatment resistance, the expression of 669 kinase-encoding genes was first compared using DNA microarray data (GSE67089) (18) from 30 primary glioma sphere cultures and three human fetal brain-derived sphere cultures (control).…”

“…Glioblastoma (GBM) is one of the most malignant tumors in adults which is associated with severe outcomes (median survival, <2 years) even with maximal therapy, including surgical resection followed by radiotherapy and adjuvant chemotherapy with temozolomide (1,2). The majority of GBM patients have been reported to suffer post-treatment recurrence, due to radiotherapy and chemotherapy resistance (3). Therefore, clarifying the mechanism for GBM treatment resistance may help to identify a novel therapeutic target for the treatment of GBM.…”