A433Objectives: Obesity is associated with an increased risk of breast cancer, and is also positively associated with tumor size and a higher probability of having positive axillary lymph nodes and faster growing tumors. It has been suggested that up to 50 % of postmenopausal breast cancers are attributable to obesity. Accordingly, this study assessed the impact of lifestyle intervention on body mass index (BMI) in women with breast cancer. MethOds: This is a randomized clinical trial study .The Study samples were 80 women with stage I, II, or III breast cancer, that operated for breast cancer and their chemotherapy or radiation therapy completed 3-18 months ago. They are divided randomly into two groups; control group and lifestyle interventions group. Those in the lifestyle intervention group were instructed to practice aerobic exercises 45-60 minutes three times per week for 24 weeks with dietary energy restriction training. Those in the control group were instructed to continue normal activities and their routine health care. Data were obtained from the patient information form and body mass index form that completed before and after the lifestyle intervention in both groups. Results: No baseline differences existed between the two groups for the mean of BMI (p = 0.366) before the study ; but the mean of BMI in the lifestyle intervention group after the intervention decreased to 25.12 ± 2.86, while in the control group it increased to 30.42 ± 6.89. The difference between the mean of BMI among the two groups after the intervention was statistically high (p = < 0.001). cOnclusiOns: Lifestyle intervention could be considered as part of a cancer survivorship program. For women with breast cancer, lifestyle intervention can decrease body mass index. Additional research in lifestyle intervention along with cognitive behavioral therapy also may be beneficial.

A433Objectives: Obesity is associated with an increased risk of breast cancer, and is also positively associated with tumor size and a higher probability of having positive axillary lymph nodes and faster growing tumors. It has been suggested that up to 50 % of postmenopausal breast cancers are attributable to obesity. Accordingly, this study assessed the impact of lifestyle intervention on body mass index (BMI) in women with breast cancer. MethOds: This is a randomized clinical trial study .The Study samples were 80 women with stage I, II, or III breast cancer, that operated for breast cancer and their chemotherapy or radiation therapy completed 3-18 months ago. They are divided randomly into two groups; control group and lifestyle interventions group. Those in the lifestyle intervention group were instructed to practice aerobic exercises 45-60 minutes three times per week for 24 weeks with dietary energy restriction training. Those in the control group were instructed to continue normal activities and their routine health care. Data were obtained from the patient information form and body mass index form that completed before and after the lifestyle intervention in both groups. Results: No baseline differences existed between the two groups for the mean of BMI (p = 0.366) before the study ; but the mean of BMI in the lifestyle intervention group after the intervention decreased to 25.12 ± 2.86, while in the control group it increased to 30.42 ± 6.89. The difference between the mean of BMI among the two groups after the intervention was statistically high (p = < 0.001). cOnclusiOns: Lifestyle intervention could be considered as part of a cancer survivorship program. For women with breast cancer, lifestyle intervention can decrease body mass index. Additional research in lifestyle intervention along with cognitive behavioral therapy also may be beneficial.

A 1 -A 3 1 8 A145 health departments, and other health institutions are one way to encourage receipt of these screenings. The purpose of this study was to examine the effectiveness of two preventative cancer screening mailer campaigns used by a large mid-western health system to encourage utilization of these screenings and to diagnose cancer cases. Methods: Mammogram and colonoscopy direct mail pieces were sent to age-and gender-appropriate individuals, based on national guidelines. In 2013, 91,000 mammogram mailers and 40,000 colonoscopy mailers were mailed to individuals living within the hospital service area. Individuals who received the mailer were instructed to call a phone number to schedule their screening. A customer relationship management system (CRM) was used to track who received mailers, screenings, and who was subsequently diagnosed with cancer. Differences in response and diagnosis rates are reported using counts and percents. Results: Mammogram mailers were associated with 1909 mammograms (2.1% response rate), of which 16 resulted in a breast cancer diagnosis (0.84% of all who received a mammogram). Fifty-four colonoscopies were associated with the direct mail program (0.1% response rate) of which two resulted in diagnosed cases of colorectal cancer (3.7% of all who received a colonoscopy). The ratio of mailers to diagnosed breast and colorectal cancer cases were 5,688:1 and 20,000:1, respectively. The cost per mailer was $0.33 and $0.36 per mailer for breast and colorectal cancer, respectively. ConClusions: The health system spent $1877 and $7200 in direct mail, respectively for the breast and colorectal mailers, to generate one diagnosed case of breast or colorectal cancer at the health system. Given the total lifetime cost of cancer treatment, the direct mail method of encouraging utilization of these preventative services appears to be cost-effective. PCN66