Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview

Lai, Christopher K C; Ng, Ray Kit; Leung, Sharon Shui Yee; Hui, Michael K.; Ip, Margaret

doi:10.1016/j.addr.2021.114078

Cited by 66 publications

(36 citation statements)

References 226 publications

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“…As the rapid induction of drug resistance of bacteria can compromise the efficiency of antibiotics against bacteria (Lai et al, 2021). Meanwhile, it was reported that NPs can reverse and delay the occurence of MDR (Huang et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

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Ofloxacin‐loaded HMPB NPs for Klebsiella pneumoniae eradication in the surgical wound with the combination of PTT

Liu

Zhong

Tang

et al. 2022

Biotech & Bioengineering

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Klebsiella pneumoniae (K. pneumoniae) is a common bacterium whose drug-resistant can cause surgical failures and incurable infections in hospital patients. Thus, how to reverse or delay the resistance induction has become a great challenge for development antiresistant drug. Recently, the combination of nanomaterial-loaded antibiotics with photothermal therapy showed the efficient antibacteria ability under a low dosage of antibiotics. In this study, a nanocomposite of HMPB NPs with inherent photothermal therapy capability was used to eradicate K. pneumoniae after loading with Ofloxacin, an antibiotic against K. pneumoniae in vitro and in vivo. The nanocomplexes named as Ofloxacin@HMPB@HA NPs showed a higher effect against K. pneumoniae by destroying cell integrity and inducing ATP leakage with the assistance of laser irradiation, compared with sole Ofloxacin@HMPB@HA NPs or laser irradiation. Surgical wound infection assay further demonstrated the efficient killing K. pneumoniae and promoting the formation of new tissues, as well, which was reflected by the rapid healing of surgical wound. In summary, these results indicate the great potential of this combinational tactic based on Ofloxacin@HMPB@HA NPs for preventing the failure caused by K. pneumoniae infection.

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Section: Resultsmentioning

confidence: 99%

“…As the rapid induction of drug resistance of bacteria can compromise the efficiency of antibiotics against bacteria (Lai et al, 2021).…”

Section: Ohh Nps + Nir Can Retard the Production Of Drug Resistancementioning

confidence: 99%

Ofloxacin‐loaded HMPB NPs for Klebsiella pneumoniae eradication in the surgical wound with the combination of PTT

Liu

Zhong

Tang

et al. 2022

Biotech & Bioengineering

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“…The disadvantages of drug-loaded coating mainly lie in the rapid release rate and the risk of drug resistance, which will negatively affect the drug efficiency and inhibit the final bone formation. Therefore, it is significant to develop advanced drug delivery system on the PDA-based multilayered coating to achieve a controllable release rate, and overcome drug resistance, where nanoparticles become a promising strategy as a drug carrier ( Lai et al, 2022 ). However, few clinical trials have been carried out to evaluate their safety and practical efficacy.…”

Section: Pda-mediated Components For Multilayered Coatings On Biomate...mentioning

confidence: 99%

Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Zhao

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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Repairing bone defects remains a challenge in clinical practice and the application of artificial scaffolds can enhance local bone formation, but the function of unmodified scaffolds is limited. Considering different application scenarios, the scaffolds should be multifunctionalized to meet specific demands. Inspired by the superior adhesive property of mussels, polydopamine (PDA) has attracted extensive attention due to its universal capacity to assemble on all biomaterials and promote further adsorption of multiple external components to form PDA-based multilayered coatings with multifunctional property, which can induce synergistic enhancement of new bone formation, such as immunomodulation, angiogenesis, antibiosis and antitumor property. This review will summarize mussel-inspired PDA-based multilayered coatings for enhanced bone formation, including formation mechanism and biofunction of PDA coating, as well as different functional components. The synergistic enhancement of multiple functions for better bone formation will also be discussed. This review will inspire the design and fabrication of PDA-based multilayered coatings for different application scenarios and promote deeper understanding of their effect on bone formation, but more efforts should be made to achieve clinical translation. On this basis, we present a critical conclusion, and forecast the prospects of PDA-based multilayered coatings for bone regeneration.

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“…Accordingly, antibiotics are preferentially used to strengthen their antibacterial effect. Regrettably, long term and abuse of antibiotics lead to the occurrence of bacterial resistance (Auzin et al., 2021 ; Lai et al., 2021 ; Bassetti et al., 2022 ). As predicted by World Health Organization (WHO), it could cause the death of nearly 10 million people each year by 2050.…”

Section: Introductionmentioning

confidence: 99%

Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy

Guo

Zeng

et al. 2022

Drug Delivery

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The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen ( 1 O 2 ) half-life and restricted 1 O 2 diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterial capture activities were intensively evaluated. Furthermore, its hemostasis and bactericidal efficiency against Staphylococcus aureus were assessed via in vitro and in vivo assays. First, chemical immobilization of photosensitizers led to an enhancement of its solubility. Moreover, it showed an excellent hemostasis capacity. Due to the formation of reversible covalent bonds between phenylboronic acid and diol groups on bacterial cell surface, the aerogel could capture S. aureus tightly and dramatically enhance aPDT. To sum up, the prepared aerogel illustrated excellent hemostasis capacity and antibacterial ability against S. aureus . Therefore, they have great potential to be utilized as wound dressing in clinical trials.

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Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview

Cited by 66 publications

References 226 publications

Ofloxacin‐loaded HMPB NPs for Klebsiella pneumoniae eradication in the surgical wound with the combination of PTT

Ofloxacin‐loaded HMPB NPs for Klebsiella pneumoniae eradication in the surgical wound with the combination of PTT

Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy

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