Overcoming thickened pathological skin in psoriasis via iontophoresis combined with tight junction-opening peptide AT1002 for intradermal delivery of NF-κB decoy oligodeoxynucleotide

Fukuta, Tatsuya; Tanaka, Daichi; Inoue, Shinya; Michiue, Kohki; Kogure, Kentaro

doi:10.1016/j.ijpharm.2021.120601

Cited by 13 publications

(4 citation statements)

References 44 publications

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“…Drug permeation through scaly psoriasis lesions and its subsequent retention in the deeper dermis are key determinants for effective psoriasis topical treatment [ 46 , 47 ]. Because in vivo studies of medication absorption based on human skin tissues are impractical due to ethical concerns, ex vivo psoriatic skin of mice was utilized to assess the drug penetration and retention ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Benefits of topical indigo naturalis nanofibrous patch on psoriatic skin: A transdermal strategy for botanicals

Wang

Gao

Guo

et al. 2023

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Benefits of topical indigo naturalis nanofibrous patch on psoriatic skin: A transdermal strategy for botanicals

Wang

Gao

Guo

et al. 2023

Materials Today Bio

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“…Regulation of expression and function of TJs largely depends on their composition, namely, the presence and assembly of several TJ proteins. Experimental and treatmentoriented modulation of the epidermal TJ system can therefore be exploited [52][53][54][55][56][57][58][59][60]. Alteration of expression of TJ components modifies permeability, even though the junction structures may persist morphologically [12].…”

Section: Discussionmentioning

confidence: 99%

The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions

Haftek

Oji

Feldmeyer³

et al. 2022

IJMS

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We evaluated the presence of tight junction (TJ) remnants in the stratum corneum (SC) of in vitro reconstructed human epidermis and human skin explants subjected or not to an aggressive topical treatment with beta-lipohydroxy salicylic acid (LSA) for 24 h. LSA-treated samples showed an increased presence of TJ remnants in the two lowermost layers of the SC, as quantified with standard electron microscopy. The topical aggression-induced overexpression of TJ-like cell–cell envelope fusions may influence SC functions: (1) directly, through an enhanced cohesion, and (2) indirectly, by impeding accessibility of peripheral corneodesmosomes to extracellular hydrolytic enzymes and, thus, slowing down desquamation. Observations of ichthyotic epidermis in peeling skin disease (PSD; corneodesmosin deficiency; two cases) and ichthyosis hypotrichosis sclerosing cholangitis syndrome (IHSC/NISCH; absence of claudin-1; two cases) also demonstrated increased persistence of TJ-like intercellular fusions in pathological SC and contributed to the interpretation of the diseases’ pathological mechanisms.

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“…Based on the results of this study, the authors then performed IP with a tight junction-opening peptide AT1002 analog (Arg-Arg-Arg-Gly-Gly-Phe-Cys-Ile-Gly-Arg-Leu) [ 89 ]. It has been reported that AT1002 assists in the skin permeation of topically applied drugs [ 90 ].…”

Section: Recent Advances In the Ip-mediated Transdermal Delivery Of B...mentioning

confidence: 99%

Iontophoresis of Biological Macromolecular Drugs

2022

Self Cite

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Over the last few decades, biological macromolecular drugs (e.g., peptides, proteins, and nucleic acids) have become a significant therapeutic modality for the treatment of various diseases. These drugs are considered superior to small-molecule drugs because of their high specificity and favorable safety profiles. However, such drugs are limited by their low oral bioavailability and short half-lives. Biological macromolecular drugs are typically administrated via invasive methods, e.g., intravenous or subcutaneous injections, which can be painful and induce needle phobia. Noninvasive transdermal delivery is an alternative administration route for the local and systemic delivery of biological macromolecular drugs. However, a challenge with the noninvasive transdermal delivery of biological macromolecular drugs is the outermost layer of the skin, known as the stratum corneum, which is a physical barrier that restricts the entry of extraneous macromolecules. Iontophoresis (IP) relies on the application of a low level of electricity for transdermal drug delivery, in order to facilitate the skin permeation of hydrophilic and charged molecules. The IP of several biological macromolecular drugs has recently been investigated. Herein, we review the IP-mediated noninvasive transdermal delivery of biological macromolecular drugs, their routes of skin permeation, their underlying mechanisms, and their advance applications.

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Overcoming thickened pathological skin in psoriasis via iontophoresis combined with tight junction-opening peptide AT1002 for intradermal delivery of NF-κB decoy oligodeoxynucleotide

Cited by 13 publications

References 44 publications

Benefits of topical indigo naturalis nanofibrous patch on psoriatic skin: A transdermal strategy for botanicals

Benefits of topical indigo naturalis nanofibrous patch on psoriatic skin: A transdermal strategy for botanicals

The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions

Iontophoresis of Biological Macromolecular Drugs

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