Overdose of yohimbine.

Varkey, Sam

doi:10.1136/bmj.304.6826.548-a

Cited by 23 publications

(3 citation statements)

References 8 publications

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“…The onset of action can be quick or delayed up to 3 weeks. In an earlier case reported from the UK, a patient with insulin-dependent diabetes with underlying cardiac disease manifested atrial fibrillation when yohimbine was prescribed for erectile dysfunction 6. We are not aware of reports of atrial fibrillation secondary to the use of body building supplements.…”

Section: Discussionmentioning

confidence: 88%

Bulk muscles, loose cables

Liyanage¹,

Kodali²

2014

BMJ Case Reports

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The accessibility and usage of body building supplements is on the rise with stronger internet marketing strategies by the industry. The dangers posed by the ingredients in them are underestimated. A healthy young man came to the emergency room with palpitations and feeling unwell. Initial history and clinical examination were non-contributory to find the cause. ECG showed atrial fibrillation. A detailed history for any over the counter or herbal medicine use confirmed that he was taking supplements to bulk muscle. One of the components in these supplements is yohimbine; the onset of symptoms coincided with the ingestion of this product and the patient is symptom free after stopping it. This report highlights the dangers to the public of consuming over the counter products with unknown ingredients and the consequential detrimental impact on health.

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Section: Discussionmentioning

confidence: 88%

Bulk muscles, loose cables

Liyanage¹,

Kodali²

2014

BMJ Case Reports

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“…Among the rare reported cases of yohimbine intoxication, the adverse events included: increase in blood pressure, tachycardia, paresthesias, loss of coordination, headaches, gastrointestinal disorders, agitation and even coma [25,34]. A case of atrial fibrillation after ingestion of 350 mg yohimbine has been reported [35]. The toxicity of each of these alkaloids, considered separately, is partially known, but there are very few scientific articles concerning the toxicity of these alkaloids consumed concomitantly.…”

Section: Discussionmentioning

confidence: 97%

Death related to consumption of Rauvolfia sp. powder mislabeled as Tabernanthe iboga

Gicquel

Hugbart

Dévéhat

et al. 2016

Forensic Science International

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Powdered roots of iboga (Tabernanthe iboga) contain ibogaine, an alkaloid that has been used to treat addictions. We report the case of a 30-year-old woman who died after ingesting a powder labeled as Tabernanthe iboga she had bought online. Analysis of the powder revealed the absence of ibogaine but the presence of toxic alkaloids (ajmaline, yohimbine and reserpine) found in Rauvolfia sp. plant species. An original and specific LC-MS/MS method developed to quantify ajmaline, yohimbine and reserpine showed respective concentrations of 109.1ng/mL, 98.2ng/mL and 30.8ng/mL in blood, and 1528.2ng/mL, 914.2ng/mL and 561.2ng/mL in bile. Moreover, systematic toxicological analyses of biological samples showed the presence of oxazepam at therapeutic concentration and cannabinoids. Death could be attributed to ingestion of a substantial quantity of crushed roots of Rauvolfia in association with concomitant drug withdrawal.

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“…Реже встречается ЛИФП на фоне приема бисфосфонатов (в 2,2% случаев на фоне лечения золедроновой кислотой) [217][218][219][220][221][222]. Для ряда групп ЛС (ЛС, влияющие на мочеполовую систему [203][204][205][206][207], иммунодепрессанты [208][209][210][211][212][213][214][215], анестетики [216] и другие [223][224][225][226][227][228]) описаны лишь отдельные клинические случаи возникновения ЛИФП/ТП.…”

Section: Drug-induced Atrial Fibrillation лекарственно-индуцированная...unclassified

Drug-Induced Atrial Fibrillation / Atrial Flutter

Остроумова

Chernyaeva

Кочетков

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Drug-induced atrial fibrillation / flutter (DIAF) is a serious and potentially life-threatening complication of pharmacotherapy. Purpose of the work: systematization and analysis of scientific literature data on drugs, the use of which can cause the development of DIAF, as well as on epidemiology, pathophysiological mechanisms, risk factors, clinical picture, diagnosis and differential diagnosis, treatment and prevention of DIAF. Analysis of the literature has shown that many groups of drugs can cause the development of DIAF, with a greater frequency while taking anticancer drugs, drugs for the treatment of the cardiovascular, bronchopulmonary and central nervous systems. The mechanisms and main risk factors for the development of DIAF have not been finally established and are known only for certain drugs, therefore, this section requires further study. The main symptoms of DIAF are due to the severity of tachycardia and their influence on the parameters of central hemodynamics. For diagnosis, it is necessary to conduct an electrocardiogram (ECG) and Holter monitoring of an ECG and echocardiography. Differential diagnosis should be made with AF, which may be caused by other causes, as well as other rhythm and conduction disturbances. Successful treatment of DIAF is based on the principle of rapid recognition and immediate discontinuation of drugs (if possible), the use of which potentially caused the development of adverse drug reactions (ADR). The choice of management strategy: heart rate control or rhythm control, as well as the method of achievement (medication or non-medication), depends on the specific clinical situation. For the prevention of DIAF, it is necessary to instruct patients about possible symptoms and recommend self-monitoring of the pulse. It is important for practitioners to be wary of the risk of DIAF due to the variety of drugs that can potentially cause this ADR.

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Overdose of yohimbine.

Cited by 23 publications

References 8 publications

Bulk muscles, loose cables

Bulk muscles, loose cables

Death related to consumption of Rauvolfia sp. powder mislabeled as Tabernanthe iboga

Drug-Induced Atrial Fibrillation / Atrial Flutter

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