Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR‐197

Zhang, Guifang; Sun, Weibo; Zhu, Liangfu; Feng, Yingpu; Wu, Liheng; Li, Tianxiao

doi:10.1002/jcb.28313

Cited by 26 publications

(23 citation statements)

References 25 publications

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“…miR-197 depletion exerts an tumor suppressive effect on the progression of gastric cancer [ 31 ]. Moreover, miR-197 has been shown to be suppressed cell proliferation, migration, and invasion in glioblastoma [ 32 ]. Hence, these studies demonstrated that miR-197 is involved in cell proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

et al. 2020

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Recent studies have demonstrated that microRNAs (miRNAs) are involved in many pathological conditions including osteoarthritis (OA). In this study, we aimed to investigate the role of miR-197 in OA and the potential molecular mechanism. The expression levels of miR-197 was detected by quantitative real-time PCR analysis. Cell proliferation and migration abilities were performed by MTT and transwell assays. The concentrations of inflammatory cytokines, including IL-1β, IL-6, and TNF-α, were detect using ELISA assay. Furthermore, luciferase reporter and rescue assays were applied to identify the functional target gene of miR-197 in OA. The results showed that miR-197 expression was significantly downregulated in the OA cartilage tissues compared with normal cartilage tissues, accompanied by upregulation of EIF4G2 expression. An inverse correlation was found between EIF4G2 and miR-197 expressions in OA cartilage tissues. Treatment with miR-197 mimics promoted the growth and migration abilities of chondrocytes, while miR-197 inhibitors induced the opposite effects. Furthermore, restoration of miR-197 significantly decreased IL-1β, IL-6, and TNF-α expression, whereas knockdown of miR-197 led to a induction in these inflammatory mediators. Moreover, EIF4G2 was predicted and confirmed as a directly target of miR-197. Overexpressed miR-197 could downregulate EIF4G2 expression in chondrocytes, while miR-197 knockdown could elevate EIF4G2 expression. Additionally, EIF4G2 overexpression reversed the effects of miR-197 mimics on chondrocytes proliferation, migration and inflammation. Taken together, our study demonstrated that miR-197 promotes chondrocyte proliferation, increases migration, and inhibits inflammation in the pathogenesis of OA by targeting EIF4G2, indicating the potential therapeutic targets of the miR-197/EIF4G2 axis for OA treatment.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

et al. 2020

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“…Many single studies have reported that dysregulated expression of circRNAs is a poor prognostic factor in glioma patients based on multivariate Cox regression analysis [13][14][15][16][17]33]. After a subgroup analysis, we found that circRNAs with different expression levels have different prognostic features in gliomas.…”

Section: Discussionmentioning

confidence: 69%

CircRNAs as Potential Biomarkers for the Clinicopathology and Prognosis of Glioma Patients:A Meta-analysis

Ding

Yang

Geng

et al. 2020

Preprint

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Abstract Background: An increasing number of studies have reported circular RNAs (circRNAs) as new potential biomarkers for the prognosis of gliomas. However, the overall prognostic value of circRNAs for glioma remains unclear. Therefore, this study is the first comprehensive evaluation of the clinicopathological and prognostic value of dysregulated circRNAs in the treatment of glioma patients. Methods: We systematically reviewed the online databases of PubMed, Web of Science, EMBASE, and Cochrane Library to identify studies that explored the relationship between circRNA expression and clinicopathological and prognostic factors in glioma through April 11, 2020. The quality of the included studies was evaluated by the Newcastle-Ottawa Scale (NOS) checklists. Clinicopathological features were assessed by pooled odds ratios (ORs) and 95% confidence intervals (CIs), and overall survival (OS) was assessed by hazard ratios (HRs) and 95% CIs. Results: Twenty-four eligible studies, including 22 studies of clinicopathological features, 1 diagnostic study, and 18 studies of prognosis, that included a total of 1390 patients were ultimately included in this study. Meta-analysis showed that highly expressed oncogenic circRNAs were significantly related to poor clinicopathological features (age: P =0.026; tumor size: P≤0.001; tumor grade: P≤0.001; KPS: P =0.012) and worse overall survival (OS) (HR = 2.01, 95% CI: 1.61-2.50, P≤0.001). Moreover, we found that highly expressed tumor-suppressor circRNAs were related to better clinicopathological features (gender: P =0.042; age: P =0.014; tumor size: P =0.022; tumor grade: P≤0.001) and longer OS (HR = 2.70, 95% CI: 1.82-3.99, P≤0.001). Conclusions: In conclusion, there is a significant correlation between the dysregulated expression of circRNAs and the clinicopathology and prognosis of glioma patients.

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“…Circ_0029426 was upregulated in GBM tissues and this was associated with tumor size and World Health Organization grading (Zhang G. et al, 2019). Circ_0029426 was an independent prognostic factor for GBM and correlated with the poor OS (Zhang G. et al, 2019). It promotes GBM progression by sequestering miR-197 (Zhang G. et al, 2019).…”

Section: Glioblastoma (Gbm)mentioning

confidence: 95%

“…It sequesters miR-132 in GBM cells and its knockdown enhanced TMZ-sensitivity (Ding et al, 2020). Circ_0029426 was upregulated in GBM tissues and this was associated with tumor size and World Health Organization grading (Zhang G. et al, 2019). Circ_0029426 was an independent prognostic factor for GBM and correlated with the poor OS (Zhang G. et al, 2019).…”

Section: Glioblastoma (Gbm)mentioning

confidence: 95%

“…CircRNAs undergo cap-independent translation facilitated by internal ribosomal entry sites (IRESs) and m6A modification in the 5'untranslated region (5'UTR) (Abe et al, 2015). Examples of microproteins encoding circRNAs include circFBXW7, circZNF609, circMbl, circPINTexon2, and circSHPRH (Motegi et al, 2006;Akhoondi et al, 2007;Yang Y. et al, 2018;Zhang M. et al, 2018;Zhang et al, 2019).…”

Section: Functions Of Circular Rnas Encoded Microproteinsmentioning

confidence: 99%

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Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

Rajappa

Banerjee

Sharma

et al. 2020

Front. Mol. Biosci.

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Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.

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Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR‐197

Abstract: Accumulating studies indicates that circular RNAs (circRNAs) play an imperative role in modulating cancer progression and metastasis. In the previous study,

Cited by 26 publications

References 25 publications

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2

CircRNAs as Potential Biomarkers for the Clinicopathology and Prognosis of Glioma Patients:A Meta-analysis

Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

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