Overexpression of carbonic anhydrase-related protein XI promotes proliferation and invasion of gastrointestinal stromal tumors

Morimoto, Kaori; Nishimori, Isao; Takeuchi, Tamotsu; Kohsaki, Takuhiro; Okamoto, Nobuto; Taguchi, Takahiro; Yunoki, Sho; Watanabe, Ryohei; Ohtsuki, Yuji; Onishi, Saburo

doi:10.1007/s00428-005-1225-3

Cited by 23 publications

(22 citation statements)

References 16 publications

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“…TOX has been reported to be also deleted in 4% (8/205) of childhood acute lymphatic leukemia. 39 Further candidate genes within the 8q12.1-8q12.2 region are the potential oncogene CA8, which promotes growth, proliferation and invasion of carcinoma cells, [40][41][42] and the RAB2A gene encoding the ras-related rab2.…”

Section: Discussionmentioning

confidence: 99%

Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma

et al. 2009

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To determine the pattern of genetic alterations in primary central nervous system lymphomas (PCNSL), 19 PCNSL were studied by high-density single-nucleotide polymorphism arrays. Recurrent losses involved 6p21.32, 6q21, 8q12-12.2, 9p21.3, 3p14.2, 4q35.2, 10q23.21 and 12p13.2, whereas gains involved 18q21-23, 19q13.31, 19q13.43 and the entire chromosomes X and 12. Partial uniparental disomies (pUPDs) were identified in 6p and 9p21.3. These genomic alterations affected the HLA locus, the CDKN2A/p16, CDKN2B/p15 and MTAP, as well as the PRDM1, FAS, MALT1, and BCL2 genes. Increased methylation values of the CDKN2A/p16 promoter region were detected in 75% (6/8) PCNSL. Gene expression profiling showed 4/21 (20%) minimal common regions of imbalances to be associated with a differential mRNA expression affecting the FAS, STAT6, CD27, ARHGEF6 and SEPT6 genes. Collectively, this study unraveled novel genomic imbalances and pUPD with a high resolution in PCNSL and identified target genes of potential relevance in the pathogenesis of this lymphoma entity.

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Section: Discussionmentioning

confidence: 99%

Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma

et al. 2009

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“…They may be present to supply adequate quantities of H 2 CO 3 for acid secretion or be analogous to the function of CAH8, which has been shown to be involved in inhibition of the IP3 receptor during intracellular calcium activation (87). Both CAH11 and CAH9 have been implicated in the pathophysiology of gastric neoplasia (55,63). There is also slight gastric epithelial enrichment of the mitochondrial CAH 5a/b probably due to the high concentration of mitochondria in gastric parietal cells.…”

Section: Acid Secretion and Ph Homeostasismentioning

confidence: 99%

Selective gene expression by rat gastric corpus epithelium

Goebel

Stengel

Lambrecht

et al. 2011

Physiological Genomics

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The gastrointestinal (GI) tract is divided into several segments that have distinct functional properties, largely absorptive. The gastric corpus is the only segment thought of as largely secretory. Microarray hybridization of the gastric corpus mucosal epithelial cells was used to compare gene expression with other segments of the columnar GI tract followed by statistical data subtraction to identify genes selectively expressed by the rat gastric corpus mucosa. This provides a means of identifying less obvious specific functions of the corpus in addition to its secretionrelated genes. For example, important properties found by this GI tract comparative transcriptome reflect the energy demand of acid secretion, a role in lipid metabolism, the large variety of resident neuroendocrine cells, responses to damaging agents and transcription factors defining differentiation of its epithelium. In terms of overlap of gastric corpus genes with the rest of the GI tract, the distal small bowel appears to express many of the gastric corpus genes in contrast to proximal small and large bowel. This differential map of gene expression by the gastric corpus epithelium will allow a more detailed description of major properties of the gastric corpus and may lead to the discovery of gastric corpus cell differentiation genes and those mis-regulated in gastric carcinomas.transcriptome; stomach THE FUNCTION OF AN ORGAN DEPENDS on the genes and protein products expressed and their regulation. Much has been learnt by classical physiological or biochemical approaches, but the complexity of biology suggests that many functions may be overlooked by conventional approaches. If a complete and specific gene expression profile were available, a more realistic understanding of a specific organ's capabilities would ensue.The gastric corpus epithelium is the most complicated region of the gastrointestinal (GI) tract in terms of secretion, endocrine function, and differentiation due to its large variety of cell types. In this article, we present the specific transcriptome of the rat gastric corpus mucosa as obtained by whole rat genome microarray hybridization compared with three other mucosal segments of the columnar GI tract (proximal and distal small bowel, and colon). This is followed by statistical data subtraction to identify genes selectively expressed by the rat gastric corpus mucosa, but not by the other segments. Genes identified with this method most likely reflect functional importance in the stomach when considered in the context of relative rather than absolute expression levels. For example, many receptors are expressed at relatively low levels but their increased expression relative to other regions of the GI tract indicates significant function in the gastric secretory epithelium. The success of this method has been previously shown during transcriptomal analysis of purified suspensions of individual cell types, such as parietal and enterochromaffin-like (ECL) cells compared with the primary mucosal digest of the gastric corpus m...

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“…Ectopic expression of CARP XI in GIST-T1 cells induced cell proliferation and invasion in vitro. These findings indicate that CARP XI plays a role in the development of GIST 11 . Additionally, expression pattern of human CA11 gene from nearly 20,000 microarrays is available in MediSapiens.…”

Section: Carp XI In Pathological Conditionsmentioning

confidence: 58%

“…So far, only few reports have been published on CARP X and XI mainly related to their expression in human and mice 5,6 . Previous studies suggest that CARP XI is associated with gastrointestinal tumors 11 .…”

Section: Introductionmentioning

confidence: 97%