Overexpression of caveolin-1 in adult T-cell leukemia

Shibata, Shigeki; Ishikawa, Chie; Tanji, Hiroe; Nakachi, Sawako; Senba, Masachika; Okudaira, Taeko; Uchihara, Jun-Nosuke; Taira, Naoya; Ohshiro, Kazuiku; Yamada, Yasuaki; Tanaka, Yuetsu; Uezato, Hiroshi; Ohshima, Koichi; Sasai, Ken; Burgering, Boudewijn M.T.; Dodon, Madeleine Duc; Fujii, Masahiro; Sunakawa, Hajime; Mori, Nozomu

doi:10.1182/blood-2009-08-240044

Cited by 9 publications

(10 citation statements)

References 49 publications

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“…This finding is attributable to the discovery of multiple fraudulent articles during the course of investigation of a single instance of fraud. For example, the retraction of a 2010 Blood article by Sawada et al (14) was followed in rapid succession by the retraction of 30 additional articles originating from the laboratory of Naoki Mori (Fig. S2).…”

Section: Resultsmentioning

confidence: 99%

Misconduct accounts for the majority of retracted scientific publications

Fang

Steen²,

Casadevall

2012

Proc. Natl. Acad. Sci. U.S.A.

965

761

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15 ps −1 and a bath temperature of 298 K were used to propagate the equations of motion within the Langevin approach. Periodic boundary conditions were applied to simulate a continuous medium." should instead appear as "A friction coefficient of 10 ps −1 and a bath temperature of 298 K were used to propagate the equations of motion within the Langevin approach. No boundary conditions were imposed; the system freely evolved in vacuum."These errors do not affect the conclusions of the article.

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Section: Resultsmentioning

confidence: 99%

Misconduct accounts for the majority of retracted scientific publications

Fang

Steen²,

Casadevall

2012

Proc. Natl. Acad. Sci. U.S.A.

965

761

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“…al (2012) observed that Cav-1 is necessary for the transformation of quiescent monocytes to active macrophages. Upregulation of Cav-1 has been observed in adult T-cell leukemia cells (Sawada et al, 2010) and macrophages undergoing apoptosis (Gargalovic and Dory, 2003), and Cav-1 has been shown to play a critical role in induction of inflammatory pathways via interleukin-1β (IL-1β) signaling and NFκB activation (Garrean et al, 2006). In the respiratory system, alveolar macrophages with an inflammatory phenotype were associated with enhanced expression of Cav-1 (Xu et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Cav-3 KO mice are viable but subject to skeletal and cardiac myopathies (Monier et al, 1995, Hagiwara et al, 2000), and our laboratory and others have demonstrated a critical role for caveolin in protection from ischemia-reperfusion injury (Bromley et al, 2001, Galbiati et al, 2001, Chidlow and Sessa, 2010, Stary et al, 2012). MLR-mediated signal transduction is an important element in the activation of the immune system (Gargalovic and Dory, 2003, Ohnuma et al, 2004, 2009, Sawada et al, 2010, Fu et al, 2012) and inflammatory response (Oakley et al, 2009, Garrean et al, 2006, Feng et al, 2010, Xu et al, 2010, Hu et al, 2008), however this previous work has largely focused on the more ubiquitously expressed Cav-1 isoform. In contrast, the role of Cav-3 in immune system signaling has been relatively under-investigated.…”

Section: Introductionmentioning

confidence: 99%

Role of caveolin-3 in lymphocyte activation

et al. 2015

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Aims Caveolins are structural proteins clustered in lipid-rich regions of plasma membrane involved in coordinating signal transduction in various organ systems. While caveolin-1 (Cav-1) has been shown to regulate lymphocyte activation, the role of caveolin-3 (Cav-3) in immune system signaling has not been investigated. We tested the hypothesis that Cav-3 modulates lymphocyte activation. Main methods Lymphocyte/leukocyte subpopulations from WT and Cav-3 mice were profiled with flow cytometry. Cytokine production in quiescent and activated splenocytes from WT and Cav-3 mice was assessed with ELISA. Key findings Levels of T-cells, monocytes, and natural killer cells were not different between WT and KO mice, however KO mice had lower B-cell population-percentage. Functionally, activated lymphocytes from Cav-3 KO mice demonstrated significantly reduced expression of IL-2 compared to WT, while expression of TNFα, IL-6, and IL-10 was not different. Finally, expression of IL-17 was significantly reduced in T-helper cells from KO mice, while IFNγ was not, suggesting that Cav-3 is a determinant in the development of the Th-17 subpopulation. Significance This study is the first to demonstrate that Cav-3 may be a novel participant in B-cell expression, T-cell cytokine production and activation of inflammation.

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“…9 Of concern is the discovery of multiple fraudulent cases, committed by the same laboratory or individual, when investigating a single fraud instance. Sawada et al 16 was retracted from the journal, Blood. Consequently, 30 additional articles were retracted originating from the same laboratory.…”

Section: Fraud On the Risementioning

confidence: 99%

Fraud in scientific research – birth of the Concordat to uphold research integrity in the United Kingdom

Khajuria

Agha

2013

J R Soc Med

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Fraud in research has risen exponentially and recent high profile cases may just be the tip of the iceberg. This threatens to have a major impact on public health, with policy makers and clinicians acting on erroneous data. To address this, the new research "Concordat", a consensus statement on research misconduct, has been published. Can it hold the key to rebuilding public confidence in scientific research in the United Kingdom? This review focuses on the concept of research misconduct, highlighting prominent cases and discussing strategies in order to restore confidence in the validity of scientific research.

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Overexpression of caveolin-1 in adult T-cell leukemia

Abstract: Caveolin-1 is implicated in the regulation

Cited by 9 publications

References 49 publications

Misconduct accounts for the majority of retracted scientific publications

Misconduct accounts for the majority of retracted scientific publications

Role of caveolin-3 in lymphocyte activation

Fraud in scientific research – birth of the Concordat to uphold research integrity in the United Kingdom

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