Overexpression of CD168 is related to poor prognosis in oral squamous cell carcinoma

Wu, Zhi‐Zhong; Yang, Qi‐Chao; Chen, De-Run; Wan, Shu-Yen; Sun, Zhi‐Jun

doi:10.1111/odi.13766

Cited by 14 publications

(4 citation statements)

References 38 publications

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“…RHAMM expression was not an independent prognostic factor although previous studies have shown increased RHAMM expression in PC (18,19). Most RHAMM expression analyses revealed that elevated RHAMM expression was associated with worse prognostic factor in many cancers, including breast cancer (29), oral squamous cell carcinoma (30), ovarian cancer (31), lung cancer (15), colon cancer ( 16), gastric cancer (14), and pancreatic cancer (13). Our study demonstrated that RHAMM overexpression enhances the malignant potential of PC.…”

Section: Discussionmentioning

confidence: 44%

Receptor for Hyaluronic Acid-mediated Motility (RHAMM) Is Associated With Prostate Cancer Migration and Poor Prognosis

Minato

Kudo

Noguchi

et al. 2023

Cancer Genomics Proteomics

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Background/Aim: Hyaluronic acid (HA) is a large glycosaminoglycan composed of an extracellular matrix. The HA-rich microenvironment and receptors of HA have been suggested to play roles in cancer progression. The biological and clinical significance of receptor for HA-mediated motility (RHAMM), known as CD168 in prostate cancer (PC) remains unknown. This study aimed to investigate the expression of RHAMM, as well as its functional and clinical relevance in PC. Materials and Methods: HA concentration and RHAMM mRNA expression were examined in 3 PC cell lines (LNCaP, PC3 and DU145). We investigated the effect of HA and RHAMM on the migratory ability of PC cells using a transwell migration assay. Immunohistochemistry was also used to evaluate the RHAMM expression pattern in pre-treatment tissue samples from 99 patients with metastatic hormone-sensitive PC (HSPC) who received androgen deprivation therapy (ADT). Results: HA was secreted in all cultured PC cell lines. Among the total HA, lowmolecular-weight HA (LMW-HA) (<100 kDa) was detected all examined cell lines. The number of migration cells was significantly increased by adding LMW-HA. RHAMM mRNA expression was increased in DU145 cells. Knockdown of RHAMM using small-interfering RNA resulted in decreased cell migration. Immunohistochemical analysis revealed strong RHAMM expression in 31 (31.3%) patients with metastatic HSPC. A strong RHAMM expression was significantly associated with short ADT duration and poor survival in univariate and multivariate analyses. Conclusion: The size of HA is important in terms of PC progression. LMW-HA and RHAMM enhanced PC cell migration. RHAMM could be used as a novel prognostic marker in patients with metastatic HSPC.Androgen deprivation therapy (ADT) is a gold-standard treatment for patients with metastatic prostate cancer (PC). Metastatic hormone-sensitive PC (HSPC) progresses to castration-resistant PC (CRPC) despite a favorable initial ADT response. Recently, guidelines recommended a combination of abiraterone, apalutamide, or enzalutamide with ADT as firstline therapy for patients with metastatic HSPC (1, 2). However, a large retrospective study using real-world data in the United States revealed that approximately 43% of patients received ADT alone as first-line therapy for metastatic HSPC (3). Additionally, we previously demonstrated that some patients with metastatic HSPC achieved long-term survival under ADT alone (4). Therefore, biomarkers to effectively predict primary ADT response are required.The microenvironment surrounding the tumor cells plays an important role in cancer progression. Hyaluronic acid (HA) is a large glycosaminoglycan composed of an extracellular matrix. A previous study revealed that HA-rich stroma promotes tumor progression in various cancer cells (5-7). HA was detected relatively frequently and abundantly 203

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Section: Discussionmentioning

confidence: 44%

Receptor for Hyaluronic Acid-mediated Motility (RHAMM) Is Associated With Prostate Cancer Migration and Poor Prognosis

Minato

Kudo

Noguchi

et al. 2023

Cancer Genomics Proteomics

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“…Accumulating investigations have uncovered the important biological functions of circRNAs in the development of various cancers, 4 including OSCC. 20 For example, multiple circRNAs, such as circFNDC3B, circEPSTI1, and circ_LPAR3, have been identified as strong promoters in OSCC progression and metastasis. [21][22][23] Moreover, circ_0069313 contributes to OSCC immunity escape to induce this disease progression by targeting miR-325-3p/Foxp3 axis.…”

Section: Discussionmentioning

confidence: 99%

The novel circ_0004674/miR‐139‐5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma

Qi,

Zhang,

Wang

2024

Head & Neck

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BackgroundCircular RNAs (circRNAs) are an intriguing family of RNA molecules due to their crucial roles in the pathogenesis of oral squamous cell carcinoma (OSCC). Here, we sought to define the action of human circ_0004674 in OSCC progression.MethodsThe functional role of circ_0004674 was validated by determining its effect on cell growth, apoptosis, and tube formation ability of OSCC cells. For protein quantification, a western blot or immunohistochemistry method was applied. The interaction between miR‐139‐5p and circ_0004674 or zinc finger and BTB domain containing 2 (ZBTB2) was predicted by online algorithms, and their relationships were confirmed by dual‐luciferase reporter and RIP assays. Xenograft models were established to uncover circ_0004674's role in tumor growth.ResultsCirc_0004674 expression was upregulated in OSCC. Functionally, knocking down circ_0004674 led to suppressed OSCC cell progression in vitro and delayed tumor growth in vivo. Mechanistically, circ_0004674 post‐transcriptionally controlled ZBTB2 expression by competitively pairing to miR‐139‐5p. Furthermore, the deficiency of miR‐139‐5p abated circ_0004674 silencing‐mediated OSCC cell progression repression, and augmentation of ZBTB2 reversed the anticancer effect of miR‐139‐5p on OSCC.ConclusionOur findings uncover a novel regulatory cascade, the circ_0004674/miR‐139‐5p/ZBTB2 axis, with the ability to affect OSCC development in vitro and in vivo, providing a potential opportunity for development of OSCC therapy.

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“…This might explain the selective delivery of HA-CA4P-NP to OSCC cells. Low fluorescence was generated after incubation of HA-CA4P-NP with non-cancer HNEC, further indicating that HA-based NPs actively target cancer cells, probably because RHAMM receptors are highly expressed in cancer cells [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma

Sun,

Zhou,

Liu

et al. 2024

Arch Med Sci

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IntroductionTo investigate the toxicity of combretastatin A4 phosphate (CA4P) hyaluronic acid (HA) gel nanoparticles (HA-CA4P-NPs) in OSCC (oral squamous cell carcinoma).MethodsToxicity was investigated using fluorescence microscopy, MTT as-say, flow cytometry, and OSCC xenograft mouse models.ResultsCompared with CA4P, HA-CA4P-NPs generated nearly 10 times more fluorescence in OSCC cells. Cytotoxicity assays showed that HACA4P-NPs were more toxic to SCC-4 cells but not to HNECs. Remarkable necrosis was induced in SCC-4 cells after exposure to HA-CA4P-NPs, and related proteins were upregulated. Furthermore, HA-CA4P-NPs significantly reduced the tu-mour size.ConclusionsHA-CA4P-NPs improved drug release and delivery, and in-creased cytotoxicity to cancer cells.

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Overexpression of CD168 is related to poor prognosis in oral squamous cell carcinoma

Cited by 14 publications

References 38 publications

Receptor for Hyaluronic Acid-mediated Motility (RHAMM) Is Associated With Prostate Cancer Migration and Poor Prognosis

Receptor for Hyaluronic Acid-mediated Motility (RHAMM) Is Associated With Prostate Cancer Migration and Poor Prognosis

The novel circ_0004674/miR‐139‐5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma

Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma

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