Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancer

Guang-hu, LI; Gao, Yufei; Cui, Yongsheng; Zhang, Tao; Cui, Rui; Jiang, Yang; Shi, Jingwei

doi:10.3892/mmr.2016.5636

Cited by 37 publications

(25 citation statements)

References 61 publications

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“…Previous studies have shown that CD44 genetic polymorphisms are closely associated with NSCLC genesis, bone metastasis, and TNM stage [13,14]. Independently of the TNM stage, CD44 genetic polymorphisms are predictive of a poor prognosis in postoperative NSCLC patients, especially in those with lung adenocarcinoma [15].…”

Section: Discussionmentioning

confidence: 99%

Expression of Novel CD44st and MMP2 in NSCLC Tissues and Their Clinical Significance

Zhang

Hai

et al. 2017

Oncol Res Treat

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Background: Abnormal expression of some CD44 molecules in tumor tissues can induce the degradation of the extracellular matrix, and is closely associated with axillary lymph node metastasis, angiogenesis, cancer progression, and drug resistance. Patients and Methods: We measured and confirmed the expression of CD44st and MMP2 mRNAs and proteins in the cancer tissues and adjacent normal tissues of postoperative non-small cell lung cancer (NSCLC) patients with either adenocarcinoma (n = 72) or squamous cell carcinoma (n = 53) using quantitative reverse transcription polymerase chain reaction, gene sequencing, and immunohistochemical analysis. Results: CD44st and MMP2 expression were closely associated with the histopathological classification, lymph node metastasis, and TNM stage of the tumors, and the difference was statistically significant (p < 0.05). The median overall survival (OS) for the high CD44st expression group was 30.52 months (95% confidence interval (CI) 24.02-36.15); for the low expression group it was 43.23 months (95% CI 31.81-52.02) (p = 0.020). The median OS for the high MMP-2 expression group was 30.53 months (95% CI 26.69-33.31); for the low expression group it was 40.06 months (95% CI 33.55-46.45) (p = 0.022). Conclusion: The rates of CD44st and MMP2 expression were higher in squamous cell carcinomas than in adenocarcinomas, were closely associated with lymph node metastasis and TNM stage, and affected patients' prognoses.

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Section: Discussionmentioning

confidence: 99%

Expression of Novel CD44st and MMP2 in NSCLC Tissues and Their Clinical Significance

Zhang

Hai

et al. 2017

Oncol Res Treat

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“…Alternatively, these macromolecules can modify their conformation, as a response to a change of environmental conditions (i.e. pH), thus acting as a stimuli-responsive system [38,39]. In general, the external functionalization affects MSNs biocompatibility, biodistribution, pharmacokinetics, particle stability, circulation time, tumor accumulation, cellular uptake, and therapeutic efficacy [32,40,41].…”

Section: Introductionmentioning

confidence: 99%

Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers

Nairi

Medda

Piludu

et al. 2018

Chemical Engineering Journal

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Biomedical application of nanoparticles is largely associated to their fate in biological media which, in turn, is related to their surface properties. Surface functionalization plays a key role in determining biodegradation, cytotoxicity and biodistribution through interactions which may be mediated by the macromolecules occurring in biological media. A typical example is given by several proteins which lead to the formation of coated nanoparticles referred as protein corona. In this work we focus on mesoporous silica nanoparticles which, due to their intrinsic textural features, show potential as carriers for sustained drug release. Mesoporous silica nanoparticles functionalized by different biopolymers such as hyaluronic acid and chitosan were synthesized and characterized through small angle X-rays scattering, thermal analysis, and infrared spectroscopy. Biopolymer-coated mesoporous silica nanoparticles were used to investigate the interaction with bovine serum albumin, and to point out the role of different biopolymer coating. Gold-conjugated-bovine serum albumin was used to gain evidence on the occurrence of surface bound proteins enabling direct observation by transmission electron microscopy. Our findings provide insights on how different biopolymers affect the formation of a protein corona around functionalized mesoporous silica nanoparticles.

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“…be overexpressed in NSCLC and involved in the occurrence and migration of NSCLC [5]. The genes L1TD1 (LINE-1 Type Transposase Domain Containing 1) and SPAG6 (Sperm Associated Antigen 6) are tumor-specifically methylated in NSCLC [6].…”

mentioning

confidence: 99%

Microarray data analysis on gene and miRNA expression to identify biomarkers in non-small cell lung cancer

et al. 2020

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Background: The aim of this study was to gain further investigation of non-small cell lung cancer (NSCLC) tumorigenesis and identify biomarkers for clinical management of patients through comprehensive bioinformatics analysis. Methods: miRNA and mRNA microarray datasets were downloaded from GEO (Gene Expression Omnibus) database under the accession number GSE102286 and GSE101929, respectively. Genes and miRNAs with differential expression were identified in NSCLC samples compared with controls, respectively. The interaction between differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRs) was predicted, followed by functional enrichment analysis, and construction of miRNA-gene regulatory network, protein-protein interaction (PPI) network, and competing endogenous RNA (ceRNA) network. Through comprehensive bioinformatics analysis, we anticipate to find novel therapeutic targets and biomarkers for NSCLC. Results: A total of 123 DEmiRs (5 up-and 118 down-regulated miRNAs) and 924 DEGs (309 up-and 615 down-regulated genes) were identified. These genes and miRNAs were significantly involved in different pathways including adherens junction, relaxin signaling pathway, and axon guidance. Furthermore, hsa-miR-9-5p, has-miR-196a-5p and hsa-miR-31-5p, as well as hsa-miR-1, hsa-miR-218-5p and hsa-miR-135a-5p were shown to have higher degree in the miRNA-gene regulatory network and ceRNA network, respectively. Furthermore, BIRC5 and FGF2, as well as RTKN2 and SLIT3 were hubs in the PPI network and ceRNA network, respectively. Conclusion: Several pathways (adherens junction, relaxin signaling pathway, and axon guidance) miRNAs (hsa-miR-9-5p, has-miR-196a-5p, hsa-miR-31-5p, hsa-miR-1, hsa-miR-218-5p and hsa-miR-135a-5p) and genes (BIRC5, FGF2, RTKN2 and SLIT3) may play important roles in the pathogenesis of NSCLC.

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Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancer

Cited by 37 publications

References 61 publications

Expression of Novel CD44st and MMP2 in NSCLC Tissues and Their Clinical Significance

Expression of Novel CD44st and MMP2 in NSCLC Tissues and Their Clinical Significance

Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers

Microarray data analysis on gene and miRNA expression to identify biomarkers in non-small cell lung cancer

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