Overexpression of Glutathione S-Transferase a in Clear Cell Renal Cell Carcinoma

Chuang, Shang-Tian; Sugimura, Jun; Tretiakova, Maria; Papavero, Veronica; Wang, Kim; Tan, Min‐Han; Lin, Fan; Teh, Bin Tean; Yang, Ximing J.

doi:10.1309/aqxr-6b2q-pugd-638c

Cited by 18 publications

(19 citation statements)

References 20 publications

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“…[28][29][30][31][32][33][34][35][36][37][38] Renal cell carcinoma marker antibody, CD10, glutathione S-transferase-a and others have shown specificity for clear cell renal cell carcinoma, 28,29 a-Methylacyl CoA racemase is expressed in papillary renal cell carcinoma, 30 whereas parvalbumin, b-defensin 1 and most recently KIT are used as markers for chromophobe renal cell carcinoma and oncocytoma. [31][32][33] However a marker with sufficient specificity to differentiate between chromophobe renal cell carcinoma and oncocytomas has not yet been unequivocally established.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

et al. 2008

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This study evaluated the expression patterns of claudins 1, 3, 4, 7, and 8 in human renal cell carcinomas and oncocytomas and correlated expression with patient prognosis. Tissue microarrays were created from paraffinembedded tissue samples from 141 patients with renal cell carcinomas or oncocytoma (90 clear cell, 22 papillary, 17 chromophobe renal cell carcinomas, and 12 oncocytomas). The staining pattern for claudins 3, 4, 7, and 8 was membranous and/or cytoplasmic, whereas claudin 1 was predominantly membranous in both nonneoplastic renal tissue and tumors. Negative to weak claudin 3 staining was predominantly detected in Fuhrman's grade 1 and 2 clear cell renal cell carcinomas (78%; P ¼ 0.016), suggesting that upregulation of claudin 3 potentially occurs concomitantly with increasing grade of clear cell renal cell carcinomas. In addition, Kaplan-Meier univariate analysis showed a significant inverse correlation between moderate to strong claudin 3 and 4 expression with overall survival in clear cell renal cell carcinomas (P ¼ 0.038 and P ¼ 0.031). Moderate to strong claudin 7 expression was significantly more common in chromophobe renal cell carcinomas (94%) than in oncocytomas (55%; P ¼ 0.041). Claudin 8 staining was moderate to strong in 92% of oncocytomas, which differentiated them from papillary and clear cell renal cell carcinomas (14 and 12%; both Po0.0001). Only negative to weak claudin 8 staining was detected in all chromophobe renal cell carcinomas, whereas there were no claudin 8 negative oncocytomas and 8% exhibited a weak staining pattern (Po0.0001). Due to their distinctive expression patterns, claudins 7 and 8 can be used as useful immunohistochemical markers for the separation of chromophobe renal cell carcinomas from oncocytomas, whereas claudins 3 and 4 may serve as indicators of prognosis in clear cell renal cell carcinomas.

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Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

et al. 2008

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“…In addition, sarcomatoid RCC with S-100 protein positivity may resemble a malignant peripheral nerve sheath tumor. In this instance, other markers frequently expressed in CRCC, such as CD10, p504S, epithelial membrane antigen, glutathione-S-transferase a, and RCC marker, should be considered to prevent a misinterpretation [4][5][6]10,21].…”

Section: Discussionmentioning

confidence: 99%

“…Twentyfour samples of normal renal tissues were also included. Tissue microarray blocks were constructed with a 1.5 mm tissue core or 2 1.0-mm tissue cores from each case as previously reported [21].…”

Section: Methodsmentioning

confidence: 99%

Expression of S-100 protein in renal cell neoplasms

et al. 2006

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“…To date, several studies have demonstrated the diagnostic value by immunohistochemical staining of these new markers on hundreds of cases. For example, by immunohistochemical staining, glutathione S-transferase α was found highly expressed in clear-cell RCC 18 and α-methylacyl-CoA racemase in papillary RCC. 19 Some of these markers will be especially useful in distinguishing histology with more subtle differences, such as the differences between type 1 and type 2 papillary RCC 20 or between oncocytoma and chromophobe RCC (T.B.T., unpublished data, 2007).…”

Section: Differentially Expressed Genes In Different Subtypes Of Renamentioning

confidence: 99%

Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma

Furge

Dykema

Petillo

et al. 2012

CUAJ

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S21roblastoma, and mucinous tubular and spindle-cell carcinoma. Benign renal tumours such as oncocytoma and papillary adenoma have also been well described.Beginning with cytogenetic profiling decades ago, the diverse spectrum of renal pathology has generated tremendous interest in identifying their underlying molecular origin. Not surprisingly, distinct chromosomal aberrations have been correlated with some of the subtypes of renal tumours, for example, the loss of chromosome 3 in clear-cell RCC; the gain of chromosomes 7, 16 and 17 in papillary RCC; and the loss of chromosome Y in oncocytoma.2 These results were partially confirmed by more recent technology, for example, studies of the loss of heterozygosity that used microsatellite polymorphic markers and comparative genomic hybridization to confirm deletion of chromosome 3p in clear-cell RCC.3 Later on, identification of the genes responsible for hereditary RCC led to molecular studies of RCC. The genes identified in hereditary cases are thought to play an equal role in their sporadic counterparts. The best example is the VHL gene, the tumour-suppressor gene responsible for the autosomal-dominant cancer syndrome von Hippel-Lindau disease, which is characterized by clear-cell RCC, pheochromocytoma, retinal angioma and central nervous system hemangioblastoma. Mutations in VHL, loss of heterozygosity and imprinting were identified in about 70% of sporadic clear-cell RCCs, supporting an earlier hypothesis. 4 However, studies of other hereditary RCC genes found either a small number of or no mutations in the sporadic tumours of subtypes, for example, the MET proto-oncogene for hereditary papillary RCC type 1, 5,6 the BHD gene for Birt-Hogg-Dubé syndrome (characterized by a spectrum of RCC, but freCombining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma REVIEW AbstractUsing high-throughput gene-expression profiling technology, we can now gain a better understanding of the complex biology that is taking place in cancer cells. This complexity is largely dictated by the abnormal genetic makeup of the cancer cells. This abnormal genetic makeup can have profound effects on cellular activities such as cell growth, cell survival and other regulatory processes. Based on the pattern of gene expression, or molecular signatures of the tumours, we can distinguish or subclassify different types of cancers according to their cell of origin, behaviour, and the way they respond to therapeutic agents and radiation. These approaches will lead to better molecular subclassification of tumours, the basis of personalized medicine. We have, to date, done whole-genome microarray gene-expression profiling on several hundreds of kidney tumours. We adopt a combined bioinformatic approach, based on an integrative analysis of the gene-expression data. These data are used to identify both cytogenetic abnormalities and molecular pathways that are deregulated in renal cell carcinoma (RCC). For example, we have identified the d...

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Overexpression of Glutathione S-Transferase a in Clear Cell Renal Cell Carcinoma

Cited by 18 publications

References 20 publications

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

Expression of S-100 protein in renal cell neoplasms

Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma

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