Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients

Kato, Tatsuya; Daigo, Yataro; Aragaki, Masato; Ishikawa, Kenji; Sato, Masaaki; Kaji, Mitsuhito

doi:10.1016/j.lungcan.2011.05.024

Cited by 84 publications

(78 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, in the presence of PCNA, two segments in the N-and C-terminal regions of p15 around the conserved basic residues R14K15 and P100, respectively, show significantly reduced signal intensities (Fig. 1d) and increased 15 N R 2 relaxation rates (Fig. 1e).…”

Section: P15-pcna Interaction Involves An Extended Pip-box Regionmentioning

confidence: 99%

“…We have analysed the interaction of human PCNA with the same primed DNA in solution by NMR. Even at a high DNA:PCNA molar ratio of 50:1, only very small changes in the 1 H- 15 N NMR signals of PCNA were observed, and affected residues do not localize to any specific area, but are sparsely distributed on the protein surface ( Supplementary Fig. 10).…”

Section: Articlementioning

confidence: 99%

“…Overexpression of p15 correlates with tumour progression and poor prognosis in a number of human cancers [13][14][15][16] . Evidence for p15-PCNA interaction comes from yeast two-hybrid and co-immunoprecipitation experiments, but no structural detail of the direct interaction is known.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair

et al. 2015

View full text Add to dashboard Cite

The intrinsically disordered protein p15 PAF regulates DNA replication and repair by binding to the proliferating cell nuclear antigen (PCNA) sliding clamp. We present the structure of the human p15 PAF -PCNA complex. Crystallography and NMR show the central PCNA-interacting protein motif (PIP-box) of p15 PAF tightly bound to the front-face of PCNA. In contrast to other PCNA-interacting proteins, p15 PAF also contacts the inside of, and passes through, the PCNA ring. The disordered p15 PAF termini emerge at opposite faces of the ring, but remain protected from 20S proteasomal degradation. Both free and PCNA-bound p15 PAF binds DNA mainly through its histone-like N-terminal tail, while PCNA does not, and a model of the ternary complex with DNA inside the PCNA ring is consistent with electron micrographs. We propose that p15 PAF acts as a flexible drag that regulates PCNA sliding along the DNA and facilitates the switch from replicative to translesion synthesis polymerase binding.

show abstract

Section: P15-pcna Interaction Involves An Extended Pip-box Regionmentioning

confidence: 99%

Section: Articlementioning

confidence: 99%

See 1 more Smart Citation

Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The protein product of the KIAA0101/p15 PAF gene is a protein implicated in proliferation and proliferating cell nuclear antigen (PCNA)-mediated DNA repair, all the while displaying oncogenic activity when aberrantly expressed, possibly through the same aforementioned pathway (89). Overexpression of KIAA0101 has been linked to growth and invasiveness of adrenal cancer (38), a predictor of poor survival in primary lung cancer (86), breast cancer (35), hepatocellular carcinoma (106), and gastric cancer (111). Although no published studies exist on KIAA0101 expression in MPM to date, based on the above it is likely that its previously mentioned PCNA-mediated oncogenic properties may play a major part.…”

Section: Functional Enrichment Annotation Analysis Of Gene Ontologiesmentioning

confidence: 99%

Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma

Vavougios

Solenov

Hatzoglou

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

show abstract

“…transactivated by the hepatitis C virus (HCV) NS5A protein via the suppression subtractive hybridization technique by our group [8]. NS5ATP9 expression was significantly altered in numerous malignant tumors, including pancreatic cancer, colorectal adenoma and adenocarcinoma, nonsmall cell lung cancer, anaplastic thyroid carcinoma, and liver cancer [9][10][11][12][13]. NS5ATP9 is also involved in the regulation of DNA repair, apoptosis, cellular signaling pathway, cell cycle progression, and cell proliferation [11,14,15].…”

Section: Introductionmentioning

confidence: 99%

NS5ATP9 Suppresses Activation of Human Hepatic Stellate Cells, Possibly via Inhibition of Smad3/Phosphorylated-Smad3 Expression

Zhang

Liu

et al. 2014

Inflammation

View full text Add to dashboard Cite

Activation of hepatic stellate cell (HSC) is the central event in liver fibrosis. NS5ATP9 is related to many malignant tumors, but little is known about its function in HSC activation. The aim of this study is to investigate the role of NS5ATP9 in HSC activation in vitro. Genes related to liver fibrosis were detected after NS5ATP9 overexpression or silencing with or without transforming growth factor (TGF)-β1 stimulation in the human HSCs by real-time polymerase chain reaction and western blotting. Cell proliferation, migration, and apoptosis were tested, and the mechanisms underlying the effect of NS5ATP9 on HSC activation were studied. We showed that NS5ATP9 suppressed HSC activation and collagen production, with or without TGF-β1 induction. Also, NS5ATP9 inhibited cell proliferation and migration and promoted apoptosis. Furthermore, NS5ATP9 reduced basal and TGF-β1-mediated Smad3/phosphorylated-Smad3 expression. The existence of a physical complex between NS5ATP9 and Smad3 was illustrated. NS5ATP9 suppresses HSC activation, extracellular matrix production, and promotes apoptosis, in part through reducing Smad3/phosphorylated-Smad3 expression.

show abstract

Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients

Cited by 84 publications

References 26 publications

Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair

Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair

Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma

NS5ATP9 Suppresses Activation of Human Hepatic Stellate Cells, Possibly via Inhibition of Smad3/Phosphorylated-Smad3 Expression

Contact Info

Product

Resources

About