Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

Wang, Yao-Yi; Zhao, Bing; Wu, Mengyuan; Zheng, Xiao-Li; Lin, Longnian; Yin, Dong-Min

doi:10.1038/s41467-020-20552-y

Cited by 21 publications

(10 citation statements)

References 76 publications

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“…In the experiment, the researchers compared the gtoNRG1 mice with overexpression of NRG1 in GABAergic interneurons with the normal mice. gtoNRG1 mice show the cortical disinhibition in a cell, synaptic, and the neural network [6]. And the experiment also proved that the gtoNRG1 mice were hyperactive in the open-field test, which proves that the gtoNrg mice had abnormal dopamine levels.…”

Section: How the Nrg1 Influence The Schizophreniamentioning

confidence: 75%

How the Gene NRG1, Erbb4, DAOA, and DISC1 Can Affect the Schizophrenia

Zang¹

2022

HSET

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Schizophrenia is a mental disease that affects many people. Up to now, it is still difficult to cure. So, it is important to find the causes of this disease. Genes play an important role in the many cause of schizophrenia. Many researchers have found that the genes NRG1, Erbb4, DAOA, and DISC1 can cause schizophrenia by affecting some structures of the nervous system and directly or indirectly affecting the release of neurotransmitters. Of course, each gene may have a specific pathway leading to the disease. Different genes can also interact with other genes to affect diseases, such as gene NRG1 and Erbb4, gene DAOA and DISC1. This paper summarizes some recent experiments to find the relationship between genes and schizophrenia. Some of the causes of schizophrenia summarized in this paper are important for the development of drugs to treat the disease.

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Section: How the Nrg1 Influence The Schizophreniamentioning

confidence: 75%

How the Gene NRG1, Erbb4, DAOA, and DISC1 Can Affect the Schizophrenia

Zang¹

2022

HSET

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“…The AAV-PHP capsids engineering was performed as previously described [ 23 , 24 ]. pAAV-gRNA-CMV-mCherry contains the rAAV genome of interest, pUCmini-iCAP-PHP encodes the viral capsid and replication proteins, and pHelper encodes adenoviral proteins necessary for replication.…”

Section: Methodsmentioning

confidence: 99%

LRP4 is required for the olfactory association task in the piriform cortex

Yan

Xiong

et al. 2022

Cell Biosci

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Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long-term potentiation (LTP). Results In this study, we found that Lrp4 was highly expressed in layer II of the piriform cortex. Both body weight and brain weight decreased in Lrp4ECD/ECD mice without TMD (Transmembrane domain) and ICD (intracellular domain) of LRP4. However, in the piriform cortical neurons of Lrp4ECD/ECD mice, the spine density increased, and the frequency of both mEPSC (miniature excitatory postsynaptic current) and sEPSC (spontaneous excitatory postsynaptic current) was enhanced. Intriguingly, finding food in the buried food-seeking test was prolonged in both Lrp4ECD/ECD mice and Lrp4 cKO (conditional knockout of Lrp4 in the piriform cortex) mice. Conclusions This study indicated that the full length of LRP4 in the piriform cortex was necessary for maintaining synaptic plasticity and the integrity of olfactory function.

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“…Data were expressed as mean ± SEM unless otherwise indicated. The sample size justification was based on the previous studies 77 . The outliers were calculated with the Grubbs's test.…”

Section: Behavior Analysismentioning

confidence: 99%

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

et al. 2021

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Synaptic pruning during adolescence is important for appropriate neurodevelopment and synaptic plasticity. Aberrant synaptic pruning may underlie a variety of brain disorders such as schizophrenia, autism and anxiety. Dopamine D2 receptor (Drd2) is associated with several neuropsychiatric diseases and is the target of some antipsychotic drugs. Here we generate self-reporting Drd2 heterozygous (SR-Drd2+/−) rats to simultaneously visualize Drd2-positive neurons and downregulate Drd2 expression. Time course studies on the developing anterior cingulate cortex (ACC) from control and SR-Drd2+/− rats reveal important roles of Drd2 in regulating synaptic pruning rather than synapse formation. Drd2 also regulates LTD, a form of synaptic plasticity which includes some similar cellular/biochemical processes as synaptic pruning. We further demonstrate that Drd2 regulates synaptic pruning via cell-autonomous mechanisms involving activation of mTOR signaling. Deficits of Drd2-mediated synaptic pruning in the ACC during adolescence lead to hyper-glutamatergic function and anxiety-like behaviors in adulthood. Taken together, our results demonstrate important roles of Drd2 in cortical synaptic pruning.

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Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

Cited by 21 publications

References 76 publications

How the Gene NRG1, Erbb4, DAOA, and DISC1 Can Affect the Schizophrenia

How the Gene NRG1, Erbb4, DAOA, and DISC1 Can Affect the Schizophrenia

LRP4 is required for the olfactory association task in the piriform cortex

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

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