Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

Cha, Mee‐Kyung; Suh, Kyung-Hoon; Kim, Il Han

doi:10.1186/1756-9966-28-93

Cited by 138 publications

(129 citation statements)

References 31 publications

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“…found that PRDX1 is more abundant in breast cancer cell lines (including ER+ and ER‐) than in normal or pseudonormal breast cell lines, but not found a significant difference in PRDX1 levels between ER+ and ER‐ breast cancer cell lines 50. However, other studies have shown that elevated mRNA expression of PRDX1 in human breast carcinoma is relevant with higher tumour grade 51, and high expression of cytoplasmic PRDX1 correlated with a great risk of local recurrence after radiotherapy 52. PRDX1 could act as a chaperone to enhance the transactivation potential of NF‐κB in ER‐breast cancer cells, and then suppresses tumour cell death 50.…”

Section: Prdx1 and Breast Cancermentioning

confidence: 90%

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Ding

Fan

2016

J Cellular Molecular Medi

171

131

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Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over‐oxidized on its catalytically active cysteine induced by a variety of stimuli in vitro and in vivo. In nucleus, oligomeric PRDX1 directly associates with p53 or transcription factors such as c‐Myc, NF‐κB and AR, and thus affects their bioactivities upon gene regulation, which in turn induces or suppresses cell death. Additionally, PRDX1 in cytoplasm has anti‐apoptotic potential through direct or indirect interactions with several ROS‐dependent (redox regulation) effectors, including ASK1, p66Shc, GSTpi/JNK and c‐Abl kinase. PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1‐regulated ROS‐dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers. In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.

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Section: Prdx1 and Breast Cancermentioning

confidence: 90%

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Ding

Fan

2016

J Cellular Molecular Medi

171

131

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“…18 Trx protein is, however, over-expressed in a number of cancers, and is associated with increased cell proliferation, inhibition of apoptosis, and decreased patient survival. 19 The reduced form of Trx protein inhibits the tumor suppressor protein PTEN (protein tyrosine phosphatase and tensin homolog). 20 Therefore negative regulation of Trx protein through TrxR inhibition is a significant strategy for the discovery of new anti-cancer agents.…”

Section: Introductionmentioning

confidence: 99%

Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition

Sweeney

Coyle

Kavanagh

et al. 2016

Bioorganic & Medicinal Chemistry

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“…Increased expression of Trx has been demonstrated in cells of many primary cancers including: cervical cancer (Cha et al 2009), cancer of colorectal tract (Raffel et al 2003), lung cancer , pancreas cancer (Han et al 2002) and stomach cancer (Toddy et al 2000). On the other hand, many studies suggest that overproduction of Trx plays not only active-protective role.…”

Section: Expression Of Thioredoxin System Proteins During Oxidative Smentioning

confidence: 99%

Thioredoxin system – a novel therapeutic target

Koháryová¹,

Kollárová²

2015

gpb

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Abstract. Nowadays there are numerous pathogens that have created a resistance to commonly used antibiotics and drugs. Therefore research is focused on finding new therapeutic targets and on determination of their 3D structures that could help in designing new effective substances and inhibitors. Thioredoxin system not only plays a crucial role as thiol/disulfide redox controller, it is also essential for certain organisms as the only system ensuring the redox homeostasis. It is the redox-regulating function, which makes thioredoxin and thioredoxin reductase attractive for scientific research, especially in many studies of diseases caused by redox instability. Thanks to these facts, the proteins of thioredoxin system are suitable candidates for new therapeutic purposes. In this review we summarized the basic features of the thioredoxin system, we justified why the proteins of thioredoxin system are appropriate therapeutical targets and we provided overview of the possibilities of their inhibition by several types of inhibitors.

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Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

Cited by 138 publications

References 31 publications

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition

Thioredoxin system – a novel therapeutic target

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