Overexpression of phospholipase D1 in human breast cancer tissues

Noh, Dong Young; Ahn, So Ra; Lee, Ryung-Ah; Park, In Ae; Kim, Jae Ho; Suh, Pann Ghill; Ryu, Sung Ho; Lee, Kweon Haeng; Han, Joong‐Soo

doi:10.1016/s0304-3835(00)00612-1

Cited by 187 publications

(155 citation statements)

References 30 publications

Supporting

Mentioning

146

Contrasting

Order By: Relevance

“…61 Phospholipase D overexpression has been reported for many cancer types including breast cancer cell lines and tissue samples, as well as renal and gastric cancers and is associated with mTOR-mediated pro-survival phenotypes. [62][63][64][65] Thus, modification of the intracellular phospholipid code by changes in the expression and/or activity of various phospholipid modifiers can ultimately regulate tumor progression.…”

Section: Alteration Of the Phospholipid Code During Tumor Progressionmentioning

confidence: 99%

The phospholipid code: a key component of dying cell recognition, tumor progression and host–microbe interactions

2015

View full text Add to dashboard Cite

A significant effort is made by the cell to maintain certain phospholipids at specific sites. It is well described that proteins involved in intracellular signaling can be targeted to the plasma membrane and organelles through phospholipid-binding domains. Thus, the accumulation of a specific combination of phospholipids, denoted here as the 'phospholipid code', is key in initiating cellular processes. Interestingly, a variety of extracellular proteins and pathogen-derived proteins can also recognize or modify phospholipids to facilitate the recognition of dying cells, tumorigenesis and host-microbe interactions. In this article, we discuss the importance of the phospholipid code in a range of physiological and pathological processes.

show abstract

Section: Alteration Of the Phospholipid Code During Tumor Progressionmentioning

confidence: 99%

The phospholipid code: a key component of dying cell recognition, tumor progression and host–microbe interactions

2015

View full text Add to dashboard Cite

show abstract

“…PLD activity and expression has been reported to be elevated in a majority of breast (Noh et al, 2000) and renal (Zhao et al, 2000) cancers that were examined. MDA-MB-231 breast cancer cells have very highly elevated levels of PLD activity relative to other breast cancer cells, and PLD activity was implicated in the survival of this breast cancer cell line subjected to apoptotic stress (Zhong et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Alternative phospholipase D/mTOR survival signal in human breast cancer cells

2004

View full text Add to dashboard Cite

“…Our results argue that Prdx1 has a direct role in tumour suppression in older mice by eliminating ROS and preventing oxidative DNA damage. Prdx1 and other peroxiredoxins are overexpressed in some human cancers 25 , suggesting that tumours that arise through other mechanisms may benefit from increased amounts of peroxiredoxins. Our findings further suggest that Prdx1 regulates NK cell development and cytotoxic function through both cell-autonomous and cell-nonautonomous mechanisms, and that defective NK cell activity may predispose Prdx1 mutant mice to cancer through a loss of tumour surveillance.…”

mentioning

confidence: 99%