2020
DOI: 10.3390/ijms21072360
|View full text |Cite
|
Sign up to set email alerts
|

Overexpression of Platelet-Derived Growth Factor and Its Receptor Are Correlated with Oral Tumorigenesis and Poor Prognosis in Oral Squamous Cell Carcinoma

Abstract: Oral squamous cell carcinoma (OSCC) is a cancerous disease with poor prognosis. According to the statistics, the 5-year survival rate has not improved significantly over the past 20 years. The platelet-derived growth factor (PDGF) and its signaling pathway is a key regulator of angiogenesis and tumorigenesis. High level of PDGF and its receptor (PDGFR) have been reported in several types of malignancies. In this study, we investigated the relationship of the molecular expression levels of PDGF and PDGFR with c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
36
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 42 publications
(37 citation statements)
references
References 54 publications
1
36
0
Order By: Relevance
“…Although it has been reported that PDGFA probably contributes to the carcinogenesis and progression of tumors, PDGFA exerts different roles in various types of cancers. The positive correlation between PDGFA expression and N stage was observed in gastric carcinoma, breast cancer, and oral squamous cell carcinoma, [ 8 , 9 , 18 ] suggesting that PDGFA was a possible accelerator for lymph node metastasis. PDGFA overexpression was associated with higher T stage in papillary thyroid cancer and nephroblastoma, [ 13 , 21 ] implying that PDGFA probably played an important role in the invasion of cancer cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although it has been reported that PDGFA probably contributes to the carcinogenesis and progression of tumors, PDGFA exerts different roles in various types of cancers. The positive correlation between PDGFA expression and N stage was observed in gastric carcinoma, breast cancer, and oral squamous cell carcinoma, [ 8 , 9 , 18 ] suggesting that PDGFA was a possible accelerator for lymph node metastasis. PDGFA overexpression was associated with higher T stage in papillary thyroid cancer and nephroblastoma, [ 13 , 21 ] implying that PDGFA probably played an important role in the invasion of cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…The elevated expression of PDGFA has been reported in various tumor types, such as liver cancer, breast cancer, and oral squamous cell carcinoma. [ 7 – 9 ] Many studies revealed that PDGFA promoted proliferation and invasion of cancer cells [ 10 – 13 ] and served as angiogenic factor in multiple different cancers. [ 14 – 16 ] In addition, numerous clinical studies indicated that high expression of PDGFs was positively associated with clinicopathological parameters including TNM stage, lymph node metastasis, and depth of invasion.…”
Section: Introductionmentioning
confidence: 99%
“…Upon activation, PDGFR is known to control angiogenesis in endothelial cells, and cell migration and growth in mesenchymal cells. Moreover, in healthy tissue both PDGFRs are mainly expressed in mesenchymal cells during inflammation, whereas during non-inflammatory conditions the expression is minimal [ 164 , 165 ]. In tumor biology, PDGFR activation stimulates cell growth and enhances metastatic behavior by attracting fibroblasts, which secrete factors that promote proliferation and migration of tumor cells.…”
Section: Resultsmentioning
confidence: 99%
“…The surgery combined with adjunctive therapy was regarded as the main treatment method of OSCC patients [2]. Although the advancement in diagnosis and therapy, the survival rate of OSCC patients has not increased obviously, which results in the low ve-year survival and high recurrence [3,4]. In order to improve the outcome of OSCC patients, it is quite necessary to study the biomarkers associated with the progression of cancer.…”
Section: Backgroundsmentioning
confidence: 99%